PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling

During brain development, neural precursor cells (NPCs) expand initially, and then switch to generating stage-specific neurons while maintaining self-renewal ability. Because the NPC pool at the onset of neurogenesis crucially affects the final number of each type of neuron, tight regulation is nece...

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Veröffentlicht in:	Development (Cambridge) 2022-11, Vol.149 (21)
Hauptverfasser:	Hirose, Tomonori, Sugitani, Yoshinobu, Kurihara, Hidetake, Kazama, Hiromi, Kusaka, Chiho, Noda, Tetsuo, Takahashi, Hidehisa, Ohno, Shigeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Hedgehog Proteins Neural Stem Cells - physiology Neurogenesis Neurons Signal Transduction - physiology
Online-Zugang:	Volltext
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