Precolumn derivatization LC/MS method for observation of efficient hydrogen sulfide supply to the kidney via d-cysteine degradation pathway

d-Cysteine (d-Cys) is metabolized to hydrogen sulfide (H2S) by d-amino acid oxidase (DAO)/3-mercaptopyruvate sulfurtransferase pathway. The pathway is required for H2S supplementation that ameliorates acute kidney injury after the oral administration of d-Cys in mice. However, whether the rate-limit...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2023-01, Vol.222, p.115088-115088, Article 115088
Hauptverfasser:	Sugiyama, Eiji, Higashi, Toru, Nakamura, Mao, Mizuno, Hajime, Toyo’oka, Toshimasa, Todoroki, Kenichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	d-amino acid oxidase d-cysteine Derivatization Hydrogen sulfide Kidney
Online-Zugang:	Volltext
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