Towards a gold standard functional readout to characterize In Vitro lung barriers

The development of biomimetic in vitro lung models as an alternative to animal studies is urgent to improve the predictability of the pharmacokinetics of potential new drugs. For pharmacokinetics studies, advanced in vitro lung models such as lung-chips should mimic a functional air-blood barrier. U...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2022-12, Vol.179, p.106305-106305, Article 106305
Hauptverfasser:	Doryab, Ali, Schmid, Otmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Apparent permeability Barrier integrity Biomimetic barrier model Epithelium Transepithelial electrical resistance (TEER)
Online-Zugang:	Volltext
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