A germline STAT6 gain-of-function variant is associated with early-onset allergies

The signal transducer and activator of transcription 6 (STAT6) signaling pathway plays a central role in allergic inflammation. To date, however, there have been no descriptions of STAT6 gain-of-function variants leading to allergies in humans. We report a STAT6 gain-of-function variant associated w...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of allergy and clinical immunology 2023-02, Vol.151 (2), p.565-571.e9
Hauptverfasser:	Suratannon, Narissara, Ittiwut, Chupong, Dik, Willem A., Ittiwut, Rungnapa, Meesilpavikkai, Kornvalee, Israsena, Nipan, Ingrungruanglert, Praewphan, Dalm, Virgil A.S. H., van Daele, Paul L.A., Sanpavat, Anapat, Chaijitraruch, Nataruks, Schrijver, Benjamin, Buranapraditkun, Supranee, Porntaveetus, Thantrira, Swagemakers, Sigrid M.A., IJspeert, Hanna, Palaga, Tanapat, Suphapeetiporn, Kanya, van der Spek, Peter J., Hirankarn, Nattiya, Chatchatee, Pantipa, Martin van Hagen, P., Shotelersuk, Vorasuk
Format:	Artikel
Sprache:	eng
Schlagworte:	anaphylaxis atopic dermatitis Child Cytokines - metabolism DNA food allergy Food Hypersensitivity gain of function Gain of Function Mutation Humans primary atopic disorders STAT6 STAT6 Transcription Factor - genetics STAT6 Transcription Factor - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!