Discerning Comparison of 1 and 0.5% Ethylene Glycol in Sprague-Dawley Rats with Modeled Urolithiasis
A common method of modeling urolithiasis is the use of 1 and 0.75% ethylene glycol, or a combination of ethylene glycol with other lithogens, but too rapid progression of the disease and multiple organ toxicity have been reported. We developed a urolithiasis model in Sprague-Dawley rats, in which th...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2022-09, Vol.173 (5), p.673-676 |
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| creator | Bervinova, A. V. Borozdina, N. A. Palikov, V. A. Palikova, Yu. A. Mikhailov, E. S. Kravchenko, I. N. Rykov, V. A. Ponomareva, T. I. Semushina, S. G. Pakhomova, I. A. Dyachenko, I. A. Murashev, A. N. |
| description | A common method of modeling urolithiasis is the use of 1 and 0.75% ethylene glycol, or a combination of ethylene glycol with other lithogens, but too rapid progression of the disease and multiple organ toxicity have been reported. We developed a urolithiasis model in Sprague-Dawley rats, in which the animals received a relatively low concentration of ethylene glycol (0.5%), but for a long-term period (6 weeks) followed by animal observation during the 6-week recovery period. In urine samples, signs of the urolithiasis development were observed starting from the sixth week: the presence of ketones, decrease in diuresis and urine pH; in the blood, urea, protein, and hematocrit were elevated. However, no leukocytes were detected in the urine; in the blood, no shifts in differential leukocyte count and no elevation in ALT, creatinine, cholesterol, and triglycerides were observed, which indicates the absence of multiple organ failure while using 1% ethylene glycol. In addition, the animals receiving 0.5% ethylene glycol were followed up to 12 weeks in contrast to animals receiving 1% ethylene glycol (the experiment in this case was stopped during the third week for ethical reasons). |
| doi_str_mv | 10.1007/s10517-022-05611-2 |
| format | Article |
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V. ; Borozdina, N. A. ; Palikov, V. A. ; Palikova, Yu. A. ; Mikhailov, E. S. ; Kravchenko, I. N. ; Rykov, V. A. ; Ponomareva, T. I. ; Semushina, S. G. ; Pakhomova, I. A. ; Dyachenko, I. A. ; Murashev, A. N.</creator><creatorcontrib>Bervinova, A. V. ; Borozdina, N. A. ; Palikov, V. A. ; Palikova, Yu. A. ; Mikhailov, E. S. ; Kravchenko, I. N. ; Rykov, V. A. ; Ponomareva, T. I. ; Semushina, S. G. ; Pakhomova, I. A. ; Dyachenko, I. A. ; Murashev, A. N.</creatorcontrib><description>A common method of modeling urolithiasis is the use of 1 and 0.75% ethylene glycol, or a combination of ethylene glycol with other lithogens, but too rapid progression of the disease and multiple organ toxicity have been reported. We developed a urolithiasis model in Sprague-Dawley rats, in which the animals received a relatively low concentration of ethylene glycol (0.5%), but for a long-term period (6 weeks) followed by animal observation during the 6-week recovery period. In urine samples, signs of the urolithiasis development were observed starting from the sixth week: the presence of ketones, decrease in diuresis and urine pH; in the blood, urea, protein, and hematocrit were elevated. However, no leukocytes were detected in the urine; in the blood, no shifts in differential leukocyte count and no elevation in ALT, creatinine, cholesterol, and triglycerides were observed, which indicates the absence of multiple organ failure while using 1% ethylene glycol. 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N.</creatorcontrib><title>Discerning Comparison of 1 and 0.5% Ethylene Glycol in Sprague-Dawley Rats with Modeled Urolithiasis</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>A common method of modeling urolithiasis is the use of 1 and 0.75% ethylene glycol, or a combination of ethylene glycol with other lithogens, but too rapid progression of the disease and multiple organ toxicity have been reported. We developed a urolithiasis model in Sprague-Dawley rats, in which the animals received a relatively low concentration of ethylene glycol (0.5%), but for a long-term period (6 weeks) followed by animal observation during the 6-week recovery period. In urine samples, signs of the urolithiasis development were observed starting from the sixth week: the presence of ketones, decrease in diuresis and urine pH; in the blood, urea, protein, and hematocrit were elevated. However, no leukocytes were detected in the urine; in the blood, no shifts in differential leukocyte count and no elevation in ALT, creatinine, cholesterol, and triglycerides were observed, which indicates the absence of multiple organ failure while using 1% ethylene glycol. 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We developed a urolithiasis model in Sprague-Dawley rats, in which the animals received a relatively low concentration of ethylene glycol (0.5%), but for a long-term period (6 weeks) followed by animal observation during the 6-week recovery period. In urine samples, signs of the urolithiasis development were observed starting from the sixth week: the presence of ketones, decrease in diuresis and urine pH; in the blood, urea, protein, and hematocrit were elevated. However, no leukocytes were detected in the urine; in the blood, no shifts in differential leukocyte count and no elevation in ALT, creatinine, cholesterol, and triglycerides were observed, which indicates the absence of multiple organ failure while using 1% ethylene glycol. 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| subjects | Animal experimentation Animals Biomedical and Life Sciences Biomedicine Blood Calculi, Urinary Cell Biology Cholesterol Creatinine Diuresis Ethylene Ethylene glycol Ethylenediaminetetraacetic acid Hematocrit Internal Medicine Laboratory Medicine Leukocytes Lithiasis Medical examination Pathology Rodents Toxicity Triglycerides Urinary tract diseases Urine |
| title | Discerning Comparison of 1 and 0.5% Ethylene Glycol in Sprague-Dawley Rats with Modeled Urolithiasis |
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