Design of Xenopus GLP-1-Based Long-Acting Dual GLP-1/Y2 Receptor Agonists

GLP-1 receptor (GLP-1R) and neuropeptide Y2 receptor (Y2R) dual agonists have shown great potential to treat obesity and type 2 diabetes (T2DM). We developed a multitarget strategy to design monomeric agonists based on Xenopus GLP-1 (xGLP-1) and PYY3–36 analogues with dual activation activities on G...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-10, Vol.65 (20), p.14201-14220
Hauptverfasser:	Yang, Qimeng, Tang, Weizhong, Sun, Lidan, Yan, Zhiming, Tang, Chunli, Yuan, Yongliang, Zhou, Huan, Zhou, Feng, Zhou, Siyuan, Wu, Qingqing, Song, Peng, Fang, Ting, Xu, Ronglian, Han, Jing, Jiang, Neng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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