Duyun compound green tea extracts regulate bile acid metabolism on mice induced by high-fat diet
Duyun compound green tea (DCGT) is a healthy beverage with lipid-lowering effect commonly consumed by local people, but its mechanism is not very clear. We evaluated the effect of DCGT treatment on bile acids (BA) metabolism of mice with high-fat diet (HFD) – induced hyperlipidaemia by biochemical i...
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| Veröffentlicht in: | British journal of nutrition 2023-07, Vol.130 (1), p.33-41 |
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| creator | Zhou, Xiaolu Li, Yaling Mu, Ren Wang, Chuanming Song, Yuyan Zhou, Caibi Mei, Xin |
| description | Duyun compound green tea (DCGT) is a healthy beverage with lipid-lowering effect commonly consumed by local people, but its mechanism is not very clear. We evaluated the effect of DCGT treatment on bile acids (BA) metabolism of mice with high-fat diet (HFD) – induced hyperlipidaemia by biochemical indexes and metabolomics and preliminarily determined the potential biomarkers and metabolic pathways of hyperlipidaemia mice treated with DCGT as well as investigated its lipid-lowering mechanism. The results showed that DCGT treatment could reduce HFD – induced gain in weight and improve dyslipidaemia. In addition, a total of ten types of BA were detected, of which seven changed BA metabolites were observed in HFD group mice. After DCGT treatment, glycocholic acid, tauroursodeoxycholic acid and taurochenodeoxycholic acid were significantly down-regulated, while hyodeoxycholic acid, deoxycholic acid and chenodeoxycholic acid were markedly up-regulated. These results demonstrated that DCGT treatment was able to make the BA metabolites in the liver of hyperlipidaemia mice normal and alleviate hyperlipidaemia by regulating the metabolites such as glycocholic acid, tauroursodeoxycholic acid and taurochenodeoxycholic, as well as the BA metabolic pathway and cholesterol metabolic pathway involved. |
| doi_str_mv | 10.1017/S0007114522003166 |
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We evaluated the effect of DCGT treatment on bile acids (BA) metabolism of mice with high-fat diet (HFD) – induced hyperlipidaemia by biochemical indexes and metabolomics and preliminarily determined the potential biomarkers and metabolic pathways of hyperlipidaemia mice treated with DCGT as well as investigated its lipid-lowering mechanism. The results showed that DCGT treatment could reduce HFD – induced gain in weight and improve dyslipidaemia. In addition, a total of ten types of BA were detected, of which seven changed BA metabolites were observed in HFD group mice. After DCGT treatment, glycocholic acid, tauroursodeoxycholic acid and taurochenodeoxycholic acid were significantly down-regulated, while hyodeoxycholic acid, deoxycholic acid and chenodeoxycholic acid were markedly up-regulated. These results demonstrated that DCGT treatment was able to make the BA metabolites in the liver of hyperlipidaemia mice normal and alleviate hyperlipidaemia by regulating the metabolites such as glycocholic acid, tauroursodeoxycholic acid and taurochenodeoxycholic, as well as the BA metabolic pathway and cholesterol metabolic pathway involved.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114522003166</identifier><identifier>PMID: 36210537</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Bile acids ; Bile Acids and Salts - metabolism ; Biomarkers ; Chenodeoxycholic acid ; Cholesterol ; Cholesterol - metabolism ; Deoxycholic acid ; Diet ; Diet, High-Fat - adverse effects ; Dyslipidemia ; Glycocholic Acid - metabolism ; Green tea ; High fat diet ; Hyperlipidemia ; Hyperlipidemias - drug therapy ; Hyperlipidemias - etiology ; Hyperlipidemias - metabolism ; Ions ; Lipid Metabolism ; Lipids ; Liver - metabolism ; Metabolic Diseases ; Metabolic pathways ; Metabolism and Metabolic Studies ; Metabolites ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Plant Extracts - metabolism ; Plant Extracts - pharmacology ; Taurochenodeoxycholic Acid - metabolism ; Taurochenodeoxycholic Acid - pharmacology ; Tauroursodeoxycholic acid ; Tea ; Tea - chemistry</subject><ispartof>British journal of nutrition, 2023-07, Vol.130 (1), p.33-41</ispartof><rights>The Author(s), 2022. 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These results demonstrated that DCGT treatment was able to make the BA metabolites in the liver of hyperlipidaemia mice normal and alleviate hyperlipidaemia by regulating the metabolites such as glycocholic acid, tauroursodeoxycholic acid and taurochenodeoxycholic, as well as the BA metabolic pathway and cholesterol metabolic pathway involved.</description><subject>Animals</subject><subject>Bile acids</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Biomarkers</subject><subject>Chenodeoxycholic acid</subject><subject>Cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>Deoxycholic acid</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dyslipidemia</subject><subject>Glycocholic Acid - metabolism</subject><subject>Green tea</subject><subject>High fat diet</subject><subject>Hyperlipidemia</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Hyperlipidemias - etiology</subject><subject>Hyperlipidemias - 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Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Xiaolu</au><au>Li, Yaling</au><au>Mu, Ren</au><au>Wang, Chuanming</au><au>Song, Yuyan</au><au>Zhou, Caibi</au><au>Mei, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duyun compound green tea extracts regulate bile acid metabolism on mice induced by high-fat diet</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2023-07-14</date><risdate>2023</risdate><volume>130</volume><issue>1</issue><spage>33</spage><epage>41</epage><pages>33-41</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>Duyun compound green tea (DCGT) is a healthy beverage with lipid-lowering effect commonly consumed by local people, but its mechanism is not very clear. We evaluated the effect of DCGT treatment on bile acids (BA) metabolism of mice with high-fat diet (HFD) – induced hyperlipidaemia by biochemical indexes and metabolomics and preliminarily determined the potential biomarkers and metabolic pathways of hyperlipidaemia mice treated with DCGT as well as investigated its lipid-lowering mechanism. The results showed that DCGT treatment could reduce HFD – induced gain in weight and improve dyslipidaemia. In addition, a total of ten types of BA were detected, of which seven changed BA metabolites were observed in HFD group mice. After DCGT treatment, glycocholic acid, tauroursodeoxycholic acid and taurochenodeoxycholic acid were significantly down-regulated, while hyodeoxycholic acid, deoxycholic acid and chenodeoxycholic acid were markedly up-regulated. These results demonstrated that DCGT treatment was able to make the BA metabolites in the liver of hyperlipidaemia mice normal and alleviate hyperlipidaemia by regulating the metabolites such as glycocholic acid, tauroursodeoxycholic acid and taurochenodeoxycholic, as well as the BA metabolic pathway and cholesterol metabolic pathway involved.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>36210537</pmid><doi>10.1017/S0007114522003166</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6593-8548</orcidid></addata></record> |
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| subjects | Animals Bile acids Bile Acids and Salts - metabolism Biomarkers Chenodeoxycholic acid Cholesterol Cholesterol - metabolism Deoxycholic acid Diet Diet, High-Fat - adverse effects Dyslipidemia Glycocholic Acid - metabolism Green tea High fat diet Hyperlipidemia Hyperlipidemias - drug therapy Hyperlipidemias - etiology Hyperlipidemias - metabolism Ions Lipid Metabolism Lipids Liver - metabolism Metabolic Diseases Metabolic pathways Metabolism and Metabolic Studies Metabolites Metabolomics Mice Mice, Inbred C57BL Plant Extracts - metabolism Plant Extracts - pharmacology Taurochenodeoxycholic Acid - metabolism Taurochenodeoxycholic Acid - pharmacology Tauroursodeoxycholic acid Tea Tea - chemistry |
| title | Duyun compound green tea extracts regulate bile acid metabolism on mice induced by high-fat diet |
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