Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress

Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a decline in its metabolism directly reflects on brain function. Weighing on recent evidence, here we systematically as...

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Veröffentlicht in:	Free radical biology & medicine 2022-11, Vol.193 (Pt 1), p.134-157
Hauptverfasser:	Dewanjee, Saikat, Chakraborty, Pratik, Bhattacharya, Hiranmoy, Chacko, Leena, Singh, Birbal, Chaudhary, Anupama, Javvaji, Kalpana, Pradhan, Saumya Ranjan, Vallamkondu, Jayalakshmi, Dey, Abhijit, Kalra, Rajkumar Singh, Jha, Niraj Kumar, Jha, Saurabh Kumar, Reddy, P. Hemachandra, Kandimalla, Ramesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer's disease (AD) Amyloid beta-Peptides - metabolism Dementia Diabetes Disease Progression Glucose - metabolism Humans Insulin - metabolism Insulin signaling Mitochondria - metabolism Mitochondrial dysfunction Neurodegenerative diseases Oxidative Stress - physiology Phosphatidylinositol 3-Kinases - metabolism
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