DKK1 Promotes Tumor Immune Evasion and Impedes Anti-PD-1 Treatment by Inducing Immunosuppressive Macrophages in Gastric Cancer

Tumor-associated macrophages (TAM) have key functions in promoting a suppressive tumor immune microenvironment (TIME) and immune evasion, which largely limit treatment effects of immune-checkpoint inhibitors (ICI) in different cancers, including gastric cancer. Dickkopf-1 (DKK1) is associated with t...

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Veröffentlicht in:	Cancer immunology research 2022-12, Vol.10 (12), p.1506-1524
Hauptverfasser:	Shi, Tao, Zhang, Yipeng, Wang, Yue, Song, Xueru, Wang, Hanbing, Zhou, Xiaoyu, Liang, Kaijie, Luo, Yuting, Che, Keying, Wang, Xuan, Pan, Yunfeng, Liu, Fangcen, Yang, Ju, Liu, Qin, Yu, Lixia, Liu, Baorui, Wei, Jia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Humans Intercellular Signaling Peptides and Proteins Macrophages Mice Phosphatidylinositol 3-Kinases - metabolism Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Tumor Escape Tumor Microenvironment
Online-Zugang:	Volltext
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