The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

Blocking PD-1/PD-L1 signaling transforms cancer therapy and is assumed to unleash exhausted tumor-reactive CD8+ T cells in the tumor microenvironment (TME). However, recent studies have also indicated that the systemic tumor-reactive CD8+ T cells may respond to PD-1/PD-L1 immunotherapy. These discre...

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Veröffentlicht in:	Cell 2022-10, Vol.185 (22), p.4049-4066.e25
Hauptverfasser:	Huang, Qizhao, Wu, Xia, Wang, Zhiming, Chen, Xiangyu, Wang, Lisha, Lu, Yijun, Xiong, Dan, Liu, Qiao, Tian, Yuhan, Lin, Huayu, Guo, Junyi, Wen, Shuqiong, Dong, Wei, Yang, Xiaofan, Yuan, Yuchen, Yue, Zhengliang, Lei, Shun, Wu, Qing, Ran, Ling, Xie, Luoyingzi, Wang, Yifei, Gao, Leiqiong, Tian, Qin, Zhou, Xinyuan, Sun, Beicheng, Xu, Lifan, Tang, Zhonghui, Ye, Lilin
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-H1 Antigen CD8-Positive T-Lymphocytes draining lymph nodes exhaustion Humans Immune Checkpoint Inhibitors immune-checkpoint blockade Lymph Nodes - pathology memory CD8+ T cells Neoplasms - pathology Neoplasms - therapy Programmed Cell Death 1 Receptor Tumor Microenvironment tumor-specific CD8+ T cells
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