Dietary supplementation with low and high polymerization inulin ameliorates adipose tissue inflammation via the TLR4/NF-κB pathway mediated by gut microbiota disturbance in obese dogs

Inflammation induced by gut microbiota disorder plays an important role in promoting obesity. Inulin has beneficial effects on gut microflora and metabolic endotoxaemia. However, the chain length of inulin determines its different physiological effects. This study aimed to investigate the effect of...

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Veröffentlicht in:	Research in veterinary science 2022-12, Vol.152, p.624-632
Hauptverfasser:	Lu, Jiang, Zhu, Daoxian, Lu, Jinye, Liu, Jing, Wu, Zhi, Liu, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Antibodies Bioaccumulation Body fat Diet Dietary supplements Dogs Fatty acids Gene expression Glucose Gut microbiota High fat diet High polymerization inulin Inflammation Inflammatory response Interleukin 6 Intestinal microflora Inulin Lipopolysaccharides Low polymerization inulin Microbiota mRNA NF-κB protein Obesity Physiological effects Polymerization Proteins TLR4 protein TLR4/NF-κB pathway Toll-like receptors Tumor necrosis factor-TNF Tumor necrosis factor-α Veterinary medicine Weight control
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