S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy

Cancer immunotherapy is a powerful weapon in the fight against cancers. Cyclic dinucleotides (CDNs) have demonstrated the great potential by evoking the immune system to fight cancers. There are still a lot of unmet needs for highly active CDNs in clinical applications due to low cell permeation and...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-12, Vol.243, p.114796-114796, Article 114796
Hauptverfasser:	Xie, Zhiqiang, Lu, Liqing, Wang, Zhenghua, Luo, Qinhong, Yang, Yuchen, Fang, Tian, Chen, Ziyi, Ma, Dejun, Quan, Junmin, Xi, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor immunotherapy Deoxyribose cyclic dinucleotides SATE-based prodrugs Serum stability STING agonist
Online-Zugang:	Volltext
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