Tumor–stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade
Background cT1/2 oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. However, predicting neck lymph-node metastasis (NLM) remains challenging. Pathomorphological evaluation of tumor budding grade (TBG) and tumor–stroma ratio (TSR) reportedly can predict lymph-node...
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| Veröffentlicht in: | International journal of clinical oncology 2022-12, Vol.27 (12), p.1818-1827 |
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| creator | Sakai, Toshihiko Saito, Yuki Tateishi, Yoko Yamazawa, Sho Fukuoka, Osamu Kobayashi, Kenya Omura, Go Akashi, Ken Yoshida, Masafumi Ando, Mizuo Ebihara, Yasuhiro Yamasoba, Tatsuya |
| description | Background
cT1/2 oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. However, predicting neck lymph-node metastasis (NLM) remains challenging. Pathomorphological evaluation of tumor budding grade (TBG) and tumor–stroma ratio (TSR) reportedly can predict lymph-node metastases. Hence, this study aimed to evaluate TBG and TSR in OTSCC and investigate their relationship to occult NLM and cancer relapse.
Methods
Clinicopathological data of patients with cT1/2N0 OTSCC treated at the University of Tokyo Hospital between 2007 and 2017 were collected. TBG and TSR were evaluated using hematoxylin–eosin staining and cytokeratin AE1/AE3 immunostaining.
Results
Out of 70 patients, 16 underwent elective neck dissection in addition to primary-tumor resection, whereas 54 did not. During follow-up, NLM was found in 35 patients. NLM correlated with the pathological depth of invasion (pDOI) (
p
5 mm and stroma-rich tumors have a high risk for cancer relapse. TSR and pDOI may be promising NLM predictors in cT1/2N0 OTSCC. |
| doi_str_mv | 10.1007/s10147-022-02249-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2721639212</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2721639212</sourcerecordid><originalsourceid>FETCH-LOGICAL-c376t-fb8df533cf38116d6a97f2c80cd0dd4d193ebb444208a987d9163e44a783d46d3</originalsourceid><addsrcrecordid>eNp9kbtOwzAYhSMEEuXyAkyWWFhCfWucjKjiJlWwlNlybSe4SuzUdoZujOy8IU-CQ5CQGJD82__wneMjnSy7QPAaQcjmAUFEWQ4xHodW-f4gmyFKWM4Yw4dpJxTlVYEXx9lJCFsIESsWeJa9r4fO-c-3jxC96wTwIhoHpLCg91oZGUG77_rX3DqlQaejCOmYAIwFco3m-AkC50ULorPNoEHYDaJzQwBSt22y8dLY0dZYpXudLhuBq0EcPwWbQSljG9B4ofRZdlSLNujzn_c0e7m7XS8f8tXz_ePyZpVLwoqY15tS1QtCZE1KhApViIrVWJZQKqgUVagierOhlGJYiqpkqkIF0ZQKVhJFC0VOs6vJt_duN-gQeWfCmFZYnYJzzHBSVBjhhF7-Qbdu8Dal47isICFFCWGi8ERJ70Lwuua9N53we44gH8vhUzk8FcO_y-H7JCKTKCTYNtr_Wv-j-gIZwZUJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2890336800</pqid></control><display><type>article</type><title>Tumor–stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade</title><source>SpringerLink Journals - AutoHoldings</source><creator>Sakai, Toshihiko ; Saito, Yuki ; Tateishi, Yoko ; Yamazawa, Sho ; Fukuoka, Osamu ; Kobayashi, Kenya ; Omura, Go ; Akashi, Ken ; Yoshida, Masafumi ; Ando, Mizuo ; Ebihara, Yasuhiro ; Yamasoba, Tatsuya</creator><creatorcontrib>Sakai, Toshihiko ; Saito, Yuki ; Tateishi, Yoko ; Yamazawa, Sho ; Fukuoka, Osamu ; Kobayashi, Kenya ; Omura, Go ; Akashi, Ken ; Yoshida, Masafumi ; Ando, Mizuo ; Ebihara, Yasuhiro ; Yamasoba, Tatsuya</creatorcontrib><description>Background
cT1/2 oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. However, predicting neck lymph-node metastasis (NLM) remains challenging. Pathomorphological evaluation of tumor budding grade (TBG) and tumor–stroma ratio (TSR) reportedly can predict lymph-node metastases. Hence, this study aimed to evaluate TBG and TSR in OTSCC and investigate their relationship to occult NLM and cancer relapse.
Methods
Clinicopathological data of patients with cT1/2N0 OTSCC treated at the University of Tokyo Hospital between 2007 and 2017 were collected. TBG and TSR were evaluated using hematoxylin–eosin staining and cytokeratin AE1/AE3 immunostaining.
Results
Out of 70 patients, 16 underwent elective neck dissection in addition to primary-tumor resection, whereas 54 did not. During follow-up, NLM was found in 35 patients. NLM correlated with the pathological depth of invasion (pDOI) (
p
< 0.001), TBG (
p
= 0.008), and TSR (
p
< 0.001) in univariate analysis and pDOI (
p
= 0.01) and TSR (
p
= 0.02) in multivariate analysis. The 5-year recurrence-free survival rate (RFS) was 78% for patients with a pDOI ≤ 5 mm and stroma-poor tumors and 33% for patients with a pDOI > 5 mm and stroma-rich tumors.
Conclusion
Patients with a pDOI > 5 mm and stroma-rich tumors have a high risk for cancer relapse. TSR and pDOI may be promising NLM predictors in cT1/2N0 OTSCC.</description><identifier>ISSN: 1341-9625</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-022-02249-y</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Cancer Research ; Cytokeratin ; Lymph nodes ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Multivariate analysis ; Oncology ; Oral carcinoma ; Original Article ; Squamous cell carcinoma ; Stroma ; Surgical Oncology ; Tongue ; Tumors</subject><ispartof>International journal of clinical oncology, 2022-12, Vol.27 (12), p.1818-1827</ispartof><rights>The Author(s) under exclusive licence to Japan Society of Clinical Oncology 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-fb8df533cf38116d6a97f2c80cd0dd4d193ebb444208a987d9163e44a783d46d3</citedby><cites>FETCH-LOGICAL-c376t-fb8df533cf38116d6a97f2c80cd0dd4d193ebb444208a987d9163e44a783d46d3</cites><orcidid>0000-0002-7484-6944</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10147-022-02249-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10147-022-02249-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Sakai, Toshihiko</creatorcontrib><creatorcontrib>Saito, Yuki</creatorcontrib><creatorcontrib>Tateishi, Yoko</creatorcontrib><creatorcontrib>Yamazawa, Sho</creatorcontrib><creatorcontrib>Fukuoka, Osamu</creatorcontrib><creatorcontrib>Kobayashi, Kenya</creatorcontrib><creatorcontrib>Omura, Go</creatorcontrib><creatorcontrib>Akashi, Ken</creatorcontrib><creatorcontrib>Yoshida, Masafumi</creatorcontrib><creatorcontrib>Ando, Mizuo</creatorcontrib><creatorcontrib>Ebihara, Yasuhiro</creatorcontrib><creatorcontrib>Yamasoba, Tatsuya</creatorcontrib><title>Tumor–stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><description>Background
cT1/2 oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. However, predicting neck lymph-node metastasis (NLM) remains challenging. Pathomorphological evaluation of tumor budding grade (TBG) and tumor–stroma ratio (TSR) reportedly can predict lymph-node metastases. Hence, this study aimed to evaluate TBG and TSR in OTSCC and investigate their relationship to occult NLM and cancer relapse.
Methods
Clinicopathological data of patients with cT1/2N0 OTSCC treated at the University of Tokyo Hospital between 2007 and 2017 were collected. TBG and TSR were evaluated using hematoxylin–eosin staining and cytokeratin AE1/AE3 immunostaining.
Results
Out of 70 patients, 16 underwent elective neck dissection in addition to primary-tumor resection, whereas 54 did not. During follow-up, NLM was found in 35 patients. NLM correlated with the pathological depth of invasion (pDOI) (
p
< 0.001), TBG (
p
= 0.008), and TSR (
p
< 0.001) in univariate analysis and pDOI (
p
= 0.01) and TSR (
p
= 0.02) in multivariate analysis. The 5-year recurrence-free survival rate (RFS) was 78% for patients with a pDOI ≤ 5 mm and stroma-poor tumors and 33% for patients with a pDOI > 5 mm and stroma-rich tumors.
Conclusion
Patients with a pDOI > 5 mm and stroma-rich tumors have a high risk for cancer relapse. TSR and pDOI may be promising NLM predictors in cT1/2N0 OTSCC.</description><subject>Cancer Research</subject><subject>Cytokeratin</subject><subject>Lymph nodes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Oral carcinoma</subject><subject>Original Article</subject><subject>Squamous cell carcinoma</subject><subject>Stroma</subject><subject>Surgical Oncology</subject><subject>Tongue</subject><subject>Tumors</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kbtOwzAYhSMEEuXyAkyWWFhCfWucjKjiJlWwlNlybSe4SuzUdoZujOy8IU-CQ5CQGJD82__wneMjnSy7QPAaQcjmAUFEWQ4xHodW-f4gmyFKWM4Yw4dpJxTlVYEXx9lJCFsIESsWeJa9r4fO-c-3jxC96wTwIhoHpLCg91oZGUG77_rX3DqlQaejCOmYAIwFco3m-AkC50ULorPNoEHYDaJzQwBSt22y8dLY0dZYpXudLhuBq0EcPwWbQSljG9B4ofRZdlSLNujzn_c0e7m7XS8f8tXz_ePyZpVLwoqY15tS1QtCZE1KhApViIrVWJZQKqgUVagierOhlGJYiqpkqkIF0ZQKVhJFC0VOs6vJt_duN-gQeWfCmFZYnYJzzHBSVBjhhF7-Qbdu8Dal47isICFFCWGi8ERJ70Lwuua9N53we44gH8vhUzk8FcO_y-H7JCKTKCTYNtr_Wv-j-gIZwZUJ</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Sakai, Toshihiko</creator><creator>Saito, Yuki</creator><creator>Tateishi, Yoko</creator><creator>Yamazawa, Sho</creator><creator>Fukuoka, Osamu</creator><creator>Kobayashi, Kenya</creator><creator>Omura, Go</creator><creator>Akashi, Ken</creator><creator>Yoshida, Masafumi</creator><creator>Ando, Mizuo</creator><creator>Ebihara, Yasuhiro</creator><creator>Yamasoba, Tatsuya</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7484-6944</orcidid></search><sort><creationdate>20221201</creationdate><title>Tumor–stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade</title><author>Sakai, Toshihiko ; Saito, Yuki ; Tateishi, Yoko ; Yamazawa, Sho ; Fukuoka, Osamu ; Kobayashi, Kenya ; Omura, Go ; Akashi, Ken ; Yoshida, Masafumi ; Ando, Mizuo ; Ebihara, Yasuhiro ; Yamasoba, Tatsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-fb8df533cf38116d6a97f2c80cd0dd4d193ebb444208a987d9163e44a783d46d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cancer Research</topic><topic>Cytokeratin</topic><topic>Lymph nodes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Oral carcinoma</topic><topic>Original Article</topic><topic>Squamous cell carcinoma</topic><topic>Stroma</topic><topic>Surgical Oncology</topic><topic>Tongue</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakai, Toshihiko</creatorcontrib><creatorcontrib>Saito, Yuki</creatorcontrib><creatorcontrib>Tateishi, Yoko</creatorcontrib><creatorcontrib>Yamazawa, Sho</creatorcontrib><creatorcontrib>Fukuoka, Osamu</creatorcontrib><creatorcontrib>Kobayashi, Kenya</creatorcontrib><creatorcontrib>Omura, Go</creatorcontrib><creatorcontrib>Akashi, Ken</creatorcontrib><creatorcontrib>Yoshida, Masafumi</creatorcontrib><creatorcontrib>Ando, Mizuo</creatorcontrib><creatorcontrib>Ebihara, Yasuhiro</creatorcontrib><creatorcontrib>Yamasoba, Tatsuya</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakai, Toshihiko</au><au>Saito, Yuki</au><au>Tateishi, Yoko</au><au>Yamazawa, Sho</au><au>Fukuoka, Osamu</au><au>Kobayashi, Kenya</au><au>Omura, Go</au><au>Akashi, Ken</au><au>Yoshida, Masafumi</au><au>Ando, Mizuo</au><au>Ebihara, Yasuhiro</au><au>Yamasoba, Tatsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor–stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade</atitle><jtitle>International journal of clinical oncology</jtitle><stitle>Int J Clin Oncol</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>27</volume><issue>12</issue><spage>1818</spage><epage>1827</epage><pages>1818-1827</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>Background
cT1/2 oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. However, predicting neck lymph-node metastasis (NLM) remains challenging. Pathomorphological evaluation of tumor budding grade (TBG) and tumor–stroma ratio (TSR) reportedly can predict lymph-node metastases. Hence, this study aimed to evaluate TBG and TSR in OTSCC and investigate their relationship to occult NLM and cancer relapse.
Methods
Clinicopathological data of patients with cT1/2N0 OTSCC treated at the University of Tokyo Hospital between 2007 and 2017 were collected. TBG and TSR were evaluated using hematoxylin–eosin staining and cytokeratin AE1/AE3 immunostaining.
Results
Out of 70 patients, 16 underwent elective neck dissection in addition to primary-tumor resection, whereas 54 did not. During follow-up, NLM was found in 35 patients. NLM correlated with the pathological depth of invasion (pDOI) (
p
< 0.001), TBG (
p
= 0.008), and TSR (
p
< 0.001) in univariate analysis and pDOI (
p
= 0.01) and TSR (
p
= 0.02) in multivariate analysis. The 5-year recurrence-free survival rate (RFS) was 78% for patients with a pDOI ≤ 5 mm and stroma-poor tumors and 33% for patients with a pDOI > 5 mm and stroma-rich tumors.
Conclusion
Patients with a pDOI > 5 mm and stroma-rich tumors have a high risk for cancer relapse. TSR and pDOI may be promising NLM predictors in cT1/2N0 OTSCC.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><doi>10.1007/s10147-022-02249-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7484-6944</orcidid></addata></record> |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Cancer Research Cytokeratin Lymph nodes Medicine Medicine & Public Health Metastases Metastasis Multivariate analysis Oncology Oral carcinoma Original Article Squamous cell carcinoma Stroma Surgical Oncology Tongue Tumors |
| title | Tumor–stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade |
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