Hyperpolarized (1-13C)Alaninamide Is a Multifunctional In Vivo Sensor of Aminopeptidase N Activity, pH, and CO2

Spin hyperpolarization enables real-time metabolic imaging of carbon-13-labeled substrates. While hyperpolarized l-(1-13C)­alaninamide is a probe of the cell-surface tumor marker aminopeptidase-N (APN, CD13), its activity in vivo has not been described. Scanning the kidneys of rats infused with hype...

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Veröffentlicht in:	ACS sensors 2022-10, Vol.7 (10), p.2987-2994
Hauptverfasser:	Radaelli, Alice, Ortiz, Daniel, Michelotti, Alessia, Roche, Maxime, Hata, Ryunosuke, Sando, Shinsuke, Bonny, Olivier, Gruetter, Rolf, Yoshihara, Hikari A. I.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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