Petasites japonicus leaf extract inhibits Alzheimer's-like pathology through suppression of neuroinflammation

Neuroinflammation is a crucial pathogenic process involved in the development and deterioration of Alzheimer's disease (AD). Petasites japonicus is known for its beneficial effects on various disease states such as allergic reaction, oxidative stress and inflammation. However, it is still unkno...

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Veröffentlicht in:	Food & function 2022-10, Vol.13 (20), p.10811-10822
Hauptverfasser:	Eo, Hyeyoon, Lee, Seungmin, Kim, Seong Hye, Ju, In Gyoung, Huh, Eugene, Lim, Jeongin, Park, Sangsu, Oh, Myung Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic reactions Alzheimer's disease c-Jun protein Cell activation Dentate gyrus Functional foods & nutraceuticals Gene expression Hippocampus Hypersensitivity IL-1β In vivo methods and tests Inflammation Interleukin 6 JNK protein Kinases Lipopolysaccharides Neurodegenerative diseases Nitric oxide Nitric-oxide synthase Object recognition Oxidative stress Pattern recognition Petasites japonicus Phosphorylation Plant extracts Transcription factors Tumor necrosis factor-α
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