Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction

[Display omitted] Multidrug resistance remains the major obstacle to successful therapy for breast carcinoma. Ursolic acid (UA), a triterpenoid compound, has been regarded as a potential neoplasm chemopreventive drug in some preclinical studies since it exerts multiple biological activities. In this...

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Veröffentlicht in:	Biochemical pharmacology 2022-11, Vol.205, p.115278-115278, Article 115278
Hauptverfasser:	Luo, Fazhen, Zhao, Juanjuan, Liu, Shuo, Xue, Yuanfei, Tang, Dongyun, Yang, Jun, Mei, Ye, Li, Guowen, Xie, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine monophosphate activated protein kinase (AMPK) Adenosine Triphosphate - metabolism Aerobic glycolysis AMP-Activated Protein Kinases - metabolism Apoptosis Breast cancer Breast Neoplasms - pathology Doxorubicin - metabolism Drug Resistance, Neoplasm Female Glucose Transporter Type 1 - metabolism Humans MCF-7 Cells Mitochondria - metabolism Mitochondrial function Multidrug resistance Reactive Oxygen Species - metabolism TOR Serine-Threonine Kinases - metabolism Triterpenes - pharmacology Triterpenes - therapeutic use Ursolic Acid
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