Immunomodulatory effect of IL‐1RA in LPS‐activated macrophage/dental pulp stem cells co‐culture

Aims Lipopolysaccharides (LPS)‐activated human dental pulp stem cells (hDPSCs) and macrophage co‐cultures showed downregulated TNF‐α secretion that is modulated by hDPSCs through IDO axis, whereas the secretory levels of IL‐1β remained unchanged. Therefore, sustained production of IL‐1β could contri...

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Veröffentlicht in:	International endodontic journal 2023-01, Vol.56 (1), p.27-38
Hauptverfasser:	Gopinath, Vellore Kannan, Mohammad, Mohammad G., Sheela, Soumya
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell culture Cytokines Dental pulp Flow cytometry Gene expression human dental pulp stem cells IL‐1 receptor antagonist Immunomodulation Immunomodulators Inflammation Lipopolysaccharides Macrophages Monocytes Statistical analysis Stem cells THP‐1 Tumor necrosis factor
Online-Zugang:	Volltext
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