Design, synthesis, biological evaluation and molecular docking study of novel urea-based benzamide derivatives as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors

Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the key members of DNA repair enzymes that is responsible for the repair of DNA single-strand breaks. Inhibition of PARP-1 has been demonstrated to be a promising strategy to selectively kill tumor cells by targeting DNA repair pathway. Herein, a seri...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-12, Vol.243, p.114790-114790, Article 114790
Hauptverfasser:	Lu, Guoqing, Nie, Wenxing, Xin, Meixiu, Meng, Yingfen, Gu, Jiayi, Miao, Hui, Cheng, Xinyi, Chan, Albert S.C., Zou, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer activity Apoptosis Benzamide derivatives Diarylurea PARP-1 inhibitors
Online-Zugang:	Volltext
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