Magnetic chitosan nanoparticles loaded with Amphotericin B: Synthesis, properties and potentiation of antifungal activity against common human pathogenic fungal strains

Amphotericin B has long been regarded as the gold standard for treating invasive fungal infections despite its toxic potential. The main objective of this research was to develop a novel IONPs@CS-AmB formulation in a cost-effective manner in order to enhance AmB delivery performance, with lowering t...

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Veröffentlicht in:	International journal of biological macromolecules 2022-12, Vol.222, p.1619-1631
Hauptverfasser:	Zareshahrabadi, Zahra, Khorram, Mohammad, Pakshir, Keyvan, Tamaddon, Ali-Mohammad, Jafari, Mahboobeh, Nouraei, Hasti, Ardekani, Niloofar Torabi, Amirzadeh, Neda, Irajie, Cambyz, Barzegar, Alireza, Iraji, Aida, Zomorodian, Kamiar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B Antifungal activity antifungal properties biochemical pathways biofilm Candida albicans cell viability Chitosan coprecipitation cost effectiveness cytotoxicity fungi hemolysis Iron nanoparticles iron oxides magnetism nanoparticles pathogens
Online-Zugang:	Volltext
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