Curcumin treatment attenuates cisplatin-induced gastric mucosal inflammation and apoptosis through the NF- κ B and MAPKs signaling pathway

To investigate the protective effects of curcumin (Cur) on gastric mucosal injury induced by cisplatin (DDP), and explore possible molecular mechanisms. A mouse of gastric mucosal injury was established by intraperitoneal injection of DDP (27 mg/kg). Thirty mice were randomly divided into control gr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human & experimental toxicology 2022-09, Vol.41, p.9603271221128738-9603271221128738
Hauptverfasser:	Gao, Jinping, Liu, Yunen, Chen, Juan, Tong, Changci, Wang, Qian, Piao, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bcl-2 protein Body weight c-Myc protein Caspase-3 Cisplatin Curcumin Extracellular signal-regulated kinase Food intake Gastric mucosa Histopathology Inflammation Injuries Interleukin 1 receptors Interleukins MAP kinase Molecular modelling Myc protein MyD88 protein NF-κB protein Nuclear transport Phosphorylation Proteins Signal transduction TAK1 protein Translocation Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!