The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2–mediated antioxidant protection

The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2–mediated antioxidant protection

OBJECTIVESThis review summarises the current findings regarding the therapeutic effects of GBE and its active ingredients in relation to the Nrf2 antioxidant cascade, to provide scientific insights into the clinical applications of GBE in treating oxidative stress-induced diseases. KEY FINDINGSWe fo...

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Veröffentlicht in:Journal of pharmacy and pharmacology 2022-11, Vol.74 (12), p.1689-1699
Hauptverfasser: Li, Yue, Zhu, Xue, Wang, Ke, Zhu, Ling, Murray, Michael, Zhou, Fanfan
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container_end_page 1699
container_issue 12
container_start_page 1689
container_title Journal of pharmacy and pharmacology
container_volume 74
creator Li, Yue
Zhu, Xue
Wang, Ke
Zhu, Ling
Murray, Michael
Zhou, Fanfan
description OBJECTIVESThis review summarises the current findings regarding the therapeutic effects of GBE and its active ingredients in relation to the Nrf2 antioxidant cascade, to provide scientific insights into the clinical applications of GBE in treating oxidative stress-induced diseases. KEY FINDINGSWe found that GBE or its active ingredients activate several signalling mechanisms in cells, including the Nrf2 pathway, which is the master controller of the antioxidant defence that detoxifies reactive oxygen species (ROS). ROS-mediated cell and tissue damage contributes to ageing and pathological conditions that underlie several important human diseases, such as diabetic nephropathy (DN), ischemic stroke and age-related macular degeneration (AMD). SUMMARYGBE or its component antioxidants could be applied for the treatment and/or prevention of DN, ischemic stroke and AMD due to their capacity to activate Nrf2 signalling. These strategies may also be applicable to the treatment of other similar conditions that are induced by oxidative stress. Thus, the therapeutic applications of GBE could be expanded.
doi_str_mv 10.1093/jpp/rgac036
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title The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2–mediated antioxidant protection
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