Higher-Energy Collisional Dissociation Mass Spectral Networks for the Rapid, Semi-automated Characterization of Known and Unknown Ribonucleoside Modifications

Higher-energy collisional dissociation (HCD) of modified ribonucleosides generates characteristic and highly reproducible nucleoside-specific tandem mass spectra (MS/MS). Here, we demonstrate the capability of HCD spectra in combination with spectral matching for the semi-automated characterization...

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Veröffentlicht in:	Analytical chemistry (Washington) 2022-10, Vol.94 (40), p.13958-13967
Hauptverfasser:	Jora, Manasses, Corcoran, Daniel, Parungao, Gwenn G., Lobue, Peter A., Oliveira, Luiz F. L., Stan, George, Addepalli, Balasubrahmanyam, Limbach, Patrick A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Automation Chemistry Energy of dissociation Hydrolysates Isotope Labeling Mass spectra Matching Nucleosides Retention time Ribonucleosides - analysis RNA, Transfer Tandem Mass Spectrometry - methods tRNA
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