Quantification of canakinumab in human plasma by liquid chromatography-high resolution mass spectrometry

•First development and validation of LC-MS/HRMS assays for the quantification of canakinumab.•Simple and high-throughput sample preparation associated with on-line SPE clean-up.•Method is suitable for routine use in therapeutic drug monitoring or pharmacokinetic studies. Canakinumab is a fully-human...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2022-11, Vol.1211, p.123475-123475, Article 123475
Hauptverfasser:	Millet, Aurélien, Pescarmona, Rémi, Belot, Alexandre, Machon, Christelle, Jamilloux, Yvan, Guitton, Jérôme
Format:	Artikel
Sprache:	eng
Schlagworte:	Canakinumab drugs High resolution mass spectrometry humans immunoglobulin G ionization liquid chromatography mass spectrometry peptides pharmacokinetics proteolysis Therapeutic drug monitoring Therapeutic monoclonal antibody therapeutics
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