SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells

[Display omitted] •35 New Ph-C-DIM+Cl- derivatives were designed and synthesized, and A11, B5 and B15 were identified as new Nur77 modulators.•A11, B5 and B15 showed excellent pro-apoptosis activity in colon cancer cell lines HCT116 and SW620, while showed non-significant cytotoxicity against normal...

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Veröffentlicht in:	Bioorganic chemistry 2022-12, Vol.129, p.106156-106156, Article 106156
Hauptverfasser:	Chen, Xiaohui, Tu, Xuhuang, Zhang, Xindao, Cao, Bing, Liu, Weirong, Zhang, Jie, Xia, Yongzhen, Bao, Guoliang, Xu, Dingyu, Zhang, Xiaokun, Zeng, Zhiping, Su, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Neoplasms Oxidative Stress Protein Binding Proto-Oncogene Proteins c-bcl-2 - metabolism
Online-Zugang:	Volltext
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