Body mass index and additional risk factors for cancer in adults with cystic fibrosis
Background Adults with cystic fibrosis (CF) have an increased risk of a variety of cancers, notably gastrointestinal cancers. In CF higher body mass index (BMI) is associated with improved long-term outcomes, yet in the general population high BMI is associated with increased cancer risk. We aimed t...
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| Veröffentlicht in: | Cancer causes & control 2022-12, Vol.33 (12), p.1445-1451 |
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| creator | Knotts, Rita M. Jin, Zhezhen Doyle, John B. Keating, Claire DiMango, Emily Abrams, Julian A. |
| description | Background
Adults with cystic fibrosis (CF) have an increased risk of a variety of cancers, notably gastrointestinal cancers. In CF higher body mass index (BMI) is associated with improved long-term outcomes, yet in the general population high BMI is associated with increased cancer risk. We aimed to delineate associations between BMI and other factors with cancer risk in adults with CF.
Methods
This was a retrospective cohort study using CF Foundation Patient Registry data from 1992 to 2015. Data were collected on age, sex, CFTR mutation class, pancreatic insufficiency, and annualized data on BMI and FEV1. The primary analysis was the association between BMI and cancer, with secondary analyses focused on BMI trajectory. Multivariable logistic regression was performed, with analyses stratified by history of transplant.
Results
Of 26,199 adults with CF, 446 (1.7%) had cancer diagnosed by histology at a mean age of 40.0 years (SD 12.2), with a higher proportion of transplanted patients developing cancer (137 (3.8%) v 309(1.4%),
p
|
| doi_str_mv | 10.1007/s10552-022-01635-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2720430771</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2720430771</sourcerecordid><originalsourceid>FETCH-LOGICAL-c303t-59ef2d9fe22051c9d4337004765b0757e78209baa1879cb0a41248a551e77b693</originalsourceid><addsrcrecordid>eNp9kE1LAzEURYMoWKt_wFXAjZvRl2QyaZZa_ALBjV2HTCajqdNJzZtB--9NrSC4cPF4m3Mv3EPIKYMLBqAukYGUvACej1VCFmyPTJhUolCcy30yAS1VIXkpDskR4hIAZMVhQhbXsdnQlUWkoW_8J7V9Q23ThCHE3nY0BXyjrXVDTEjbmKizvfMpw5kauwHpRxheqdvgEBxtQ50iBjwmB63t0J_8_ClZ3N48z--Lx6e7h_nVY-EEiKGQ2re80a3nHCRzuimFUAClqmQNSiqvZhx0bS2bKe1qsCXj5cxKybxSdaXFlJzvetcpvo8eB7MK6HzX2d7HEQ1XHEoBSrGMnv1Bl3FMeeKWEoxr0KAyxXeUyzsw-dasU1jZtDEMzNa02Zk22bT5Nm221WIXwgz3Lz79Vv-T-gJxTH8V</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2731290907</pqid></control><display><type>article</type><title>Body mass index and additional risk factors for cancer in adults with cystic fibrosis</title><source>SpringerLink Journals - AutoHoldings</source><creator>Knotts, Rita M. ; Jin, Zhezhen ; Doyle, John B. ; Keating, Claire ; DiMango, Emily ; Abrams, Julian A.</creator><creatorcontrib>Knotts, Rita M. ; Jin, Zhezhen ; Doyle, John B. ; Keating, Claire ; DiMango, Emily ; Abrams, Julian A.</creatorcontrib><description>Background
Adults with cystic fibrosis (CF) have an increased risk of a variety of cancers, notably gastrointestinal cancers. In CF higher body mass index (BMI) is associated with improved long-term outcomes, yet in the general population high BMI is associated with increased cancer risk. We aimed to delineate associations between BMI and other factors with cancer risk in adults with CF.
Methods
This was a retrospective cohort study using CF Foundation Patient Registry data from 1992 to 2015. Data were collected on age, sex, CFTR mutation class, pancreatic insufficiency, and annualized data on BMI and FEV1. The primary analysis was the association between BMI and cancer, with secondary analyses focused on BMI trajectory. Multivariable logistic regression was performed, with analyses stratified by history of transplant.
Results
Of 26,199 adults with CF, 446 (1.7%) had cancer diagnosed by histology at a mean age of 40.0 years (SD 12.2), with a higher proportion of transplanted patients developing cancer (137 (3.8%) v 309(1.4%),
p
< 0.001). Among non-transplanted patients, there was no association between BMI and cancer (
p
for trend = 0.43). Pancreatic insufficiency (
p
< 0.01) and higher FEV1 (
p
< 0.01) were associated with increased cancer risk. In transplanted patients, higher BMI was associated with reduced risk of cancer (
p
for trend = 0.04). Older age was associated with increased risk in both groups (
p
< 0.001). BMI trajectories were not associated with cancer risk in either group.
Conclusion
Higher BMI is associated with a reduced risk of cancer in transplanted adults with CF. Pancreatic insufficiency is a risk factor for cancer in non-transplanted CF patients.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-022-01635-1</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adults ; Biomedical and Life Sciences ; Biomedicine ; Body mass ; Body mass index ; Body size ; Cancer ; Cancer Research ; Cystic fibrosis ; Epidemiology ; Health risks ; Hematology ; Histology ; Mutation ; Obesity ; Oncology ; Original Paper ; Pancreatic islet transplantation ; Public Health ; Risk analysis ; Risk factors ; Risk management ; Risk reduction</subject><ispartof>Cancer causes & control, 2022-12, Vol.33 (12), p.1445-1451</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c303t-59ef2d9fe22051c9d4337004765b0757e78209baa1879cb0a41248a551e77b693</cites><orcidid>0000-0002-3133-1772</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10552-022-01635-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10552-022-01635-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Knotts, Rita M.</creatorcontrib><creatorcontrib>Jin, Zhezhen</creatorcontrib><creatorcontrib>Doyle, John B.</creatorcontrib><creatorcontrib>Keating, Claire</creatorcontrib><creatorcontrib>DiMango, Emily</creatorcontrib><creatorcontrib>Abrams, Julian A.</creatorcontrib><title>Body mass index and additional risk factors for cancer in adults with cystic fibrosis</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><description>Background
Adults with cystic fibrosis (CF) have an increased risk of a variety of cancers, notably gastrointestinal cancers. In CF higher body mass index (BMI) is associated with improved long-term outcomes, yet in the general population high BMI is associated with increased cancer risk. We aimed to delineate associations between BMI and other factors with cancer risk in adults with CF.
Methods
This was a retrospective cohort study using CF Foundation Patient Registry data from 1992 to 2015. Data were collected on age, sex, CFTR mutation class, pancreatic insufficiency, and annualized data on BMI and FEV1. The primary analysis was the association between BMI and cancer, with secondary analyses focused on BMI trajectory. Multivariable logistic regression was performed, with analyses stratified by history of transplant.
Results
Of 26,199 adults with CF, 446 (1.7%) had cancer diagnosed by histology at a mean age of 40.0 years (SD 12.2), with a higher proportion of transplanted patients developing cancer (137 (3.8%) v 309(1.4%),
p
< 0.001). Among non-transplanted patients, there was no association between BMI and cancer (
p
for trend = 0.43). Pancreatic insufficiency (
p
< 0.01) and higher FEV1 (
p
< 0.01) were associated with increased cancer risk. In transplanted patients, higher BMI was associated with reduced risk of cancer (
p
for trend = 0.04). Older age was associated with increased risk in both groups (
p
< 0.001). BMI trajectories were not associated with cancer risk in either group.
Conclusion
Higher BMI is associated with a reduced risk of cancer in transplanted adults with CF. Pancreatic insufficiency is a risk factor for cancer in non-transplanted CF patients.</description><subject>Adults</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Cystic fibrosis</subject><subject>Epidemiology</subject><subject>Health risks</subject><subject>Hematology</subject><subject>Histology</subject><subject>Mutation</subject><subject>Obesity</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pancreatic islet transplantation</subject><subject>Public Health</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Risk management</subject><subject>Risk reduction</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE1LAzEURYMoWKt_wFXAjZvRl2QyaZZa_ALBjV2HTCajqdNJzZtB--9NrSC4cPF4m3Mv3EPIKYMLBqAukYGUvACej1VCFmyPTJhUolCcy30yAS1VIXkpDskR4hIAZMVhQhbXsdnQlUWkoW_8J7V9Q23ThCHE3nY0BXyjrXVDTEjbmKizvfMpw5kauwHpRxheqdvgEBxtQ50iBjwmB63t0J_8_ClZ3N48z--Lx6e7h_nVY-EEiKGQ2re80a3nHCRzuimFUAClqmQNSiqvZhx0bS2bKe1qsCXj5cxKybxSdaXFlJzvetcpvo8eB7MK6HzX2d7HEQ1XHEoBSrGMnv1Bl3FMeeKWEoxr0KAyxXeUyzsw-dasU1jZtDEMzNa02Zk22bT5Nm221WIXwgz3Lz79Vv-T-gJxTH8V</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Knotts, Rita M.</creator><creator>Jin, Zhezhen</creator><creator>Doyle, John B.</creator><creator>Keating, Claire</creator><creator>DiMango, Emily</creator><creator>Abrams, Julian A.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3133-1772</orcidid></search><sort><creationdate>20221201</creationdate><title>Body mass index and additional risk factors for cancer in adults with cystic fibrosis</title><author>Knotts, Rita M. ; Jin, Zhezhen ; Doyle, John B. ; Keating, Claire ; DiMango, Emily ; Abrams, Julian A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-59ef2d9fe22051c9d4337004765b0757e78209baa1879cb0a41248a551e77b693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adults</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Cystic fibrosis</topic><topic>Epidemiology</topic><topic>Health risks</topic><topic>Hematology</topic><topic>Histology</topic><topic>Mutation</topic><topic>Obesity</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pancreatic islet transplantation</topic><topic>Public Health</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Risk management</topic><topic>Risk reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knotts, Rita M.</creatorcontrib><creatorcontrib>Jin, Zhezhen</creatorcontrib><creatorcontrib>Doyle, John B.</creatorcontrib><creatorcontrib>Keating, Claire</creatorcontrib><creatorcontrib>DiMango, Emily</creatorcontrib><creatorcontrib>Abrams, Julian A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knotts, Rita M.</au><au>Jin, Zhezhen</au><au>Doyle, John B.</au><au>Keating, Claire</au><au>DiMango, Emily</au><au>Abrams, Julian A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index and additional risk factors for cancer in adults with cystic fibrosis</atitle><jtitle>Cancer causes & control</jtitle><stitle>Cancer Causes Control</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>33</volume><issue>12</issue><spage>1445</spage><epage>1451</epage><pages>1445-1451</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><abstract>Background
Adults with cystic fibrosis (CF) have an increased risk of a variety of cancers, notably gastrointestinal cancers. In CF higher body mass index (BMI) is associated with improved long-term outcomes, yet in the general population high BMI is associated with increased cancer risk. We aimed to delineate associations between BMI and other factors with cancer risk in adults with CF.
Methods
This was a retrospective cohort study using CF Foundation Patient Registry data from 1992 to 2015. Data were collected on age, sex, CFTR mutation class, pancreatic insufficiency, and annualized data on BMI and FEV1. The primary analysis was the association between BMI and cancer, with secondary analyses focused on BMI trajectory. Multivariable logistic regression was performed, with analyses stratified by history of transplant.
Results
Of 26,199 adults with CF, 446 (1.7%) had cancer diagnosed by histology at a mean age of 40.0 years (SD 12.2), with a higher proportion of transplanted patients developing cancer (137 (3.8%) v 309(1.4%),
p
< 0.001). Among non-transplanted patients, there was no association between BMI and cancer (
p
for trend = 0.43). Pancreatic insufficiency (
p
< 0.01) and higher FEV1 (
p
< 0.01) were associated with increased cancer risk. In transplanted patients, higher BMI was associated with reduced risk of cancer (
p
for trend = 0.04). Older age was associated with increased risk in both groups (
p
< 0.001). BMI trajectories were not associated with cancer risk in either group.
Conclusion
Higher BMI is associated with a reduced risk of cancer in transplanted adults with CF. Pancreatic insufficiency is a risk factor for cancer in non-transplanted CF patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10552-022-01635-1</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3133-1772</orcidid></addata></record> |
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| subjects | Adults Biomedical and Life Sciences Biomedicine Body mass Body mass index Body size Cancer Cancer Research Cystic fibrosis Epidemiology Health risks Hematology Histology Mutation Obesity Oncology Original Paper Pancreatic islet transplantation Public Health Risk analysis Risk factors Risk management Risk reduction |
| title | Body mass index and additional risk factors for cancer in adults with cystic fibrosis |
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