Could cytology supplant frozen section for intraoperative evaluation of thoracic lesions? A single institutional experience in a developing country
Background The diagnostic performance of cytology was compared with the frozen results and its usability was evaluated as a rapid diagnosis method in intraoperative thoracic surgery in a single institution (Istanbul, Turkey). Methods All 197 subsequent patient specimens (cases) from 158 patients who...
Gespeichert in:
| Veröffentlicht in: | Diagnostic cytopathology 2023-02, Vol.51 (2), p.123-134 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 134 |
|---|---|
| container_issue | 2 |
| container_start_page | 123 |
| container_title | Diagnostic cytopathology |
| container_volume | 51 |
| creator | Silav, Zuhal Kuş Sönmez, Cansu Aydemir, Bülent Yıldırım, Mehmet Okay, Tamer Aker, Fügen Vardar |
| description | Background
The diagnostic performance of cytology was compared with the frozen results and its usability was evaluated as a rapid diagnosis method in intraoperative thoracic surgery in a single institution (Istanbul, Turkey).
Methods
All 197 subsequent patient specimens (cases) from 158 patients who were sent to our department from the thoracic surgery clinic for an intraoperative diagnosis request between the years 2016 and 2021 were evaluated. Obtained results from frozen and cytology were compared with final paraffin section diagnoses. Lesions were grouped into three different groups as nonneoplastic, benign, and malignant neoplasms.
Results
Diagnostic accuracy values of cytology and frozen sections in intraoperative consultation were 98.8% and 99.4%, respectively. Sensitivity values of cytology and frozen sections in intraoperative consultation were 96.3% and 98.7%, respectively. Specificity values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Negative predictive values of cytology and frozen sections in intraoperative consultation were 96.7% and 98.9%, respectively. Positive predictive values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Kappa statistics between cytology and frozen revealed a very high interrater reliability (Cohen's Kappa value: 0.911; p = .001; p |
| doi_str_mv | 10.1002/dc.25060 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2720430392</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2759885758</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3100-bdabb6ac8e07b6367c227535673d3c7b2170c2b5c5223311624c7b19bb522aeb3</originalsourceid><addsrcrecordid>eNp1kctq3DAUhkVpaaZJoE9QBN1046kuI8telTC9JBDopl0bST5OFDSWq8sk7mvkhau5pIFCV4L_fPrEr4PQW0qWlBD2sTdLJkhNXqAFJa2sCOftS7RopBAVJbw9QW9ivCOEtIzWr9EJr2lDV3K1QI9rn12PzZy88zczjnmanBoTHoL_DSOOYJL1Ix58wHZMQfkJgkp2Cxi2ymW1n_oBp1sflLEGO4glip_wBY52vHFQ7sVkU96RymF4KAYLo9kNsMI9bMH5qaDY-FyemM_Qq0G5COfH8xT9_Prlx_qyuv7-7Wp9cV0ZXlpXulda18o0QKSueS0NY1JwUUvecyM1o5IYpoURjHFOac1WJaWt1iVQoPkp-nDwTsH_yhBTt7HRgCv9wefYMcnIipfvYwV9_w9653ModXaUaJtGSNE8C03wMQYYuinYjQpzR0m3W1TXm26_qIK-Owqz3kD_F3zaTAGqA3BvHcz_FXWf1wfhH-uuniA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2759885758</pqid></control><display><type>article</type><title>Could cytology supplant frozen section for intraoperative evaluation of thoracic lesions? A single institutional experience in a developing country</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Silav, Zuhal Kuş ; Sönmez, Cansu ; Aydemir, Bülent ; Yıldırım, Mehmet ; Okay, Tamer ; Aker, Fügen Vardar</creator><creatorcontrib>Silav, Zuhal Kuş ; Sönmez, Cansu ; Aydemir, Bülent ; Yıldırım, Mehmet ; Okay, Tamer ; Aker, Fügen Vardar</creatorcontrib><description>Background
The diagnostic performance of cytology was compared with the frozen results and its usability was evaluated as a rapid diagnosis method in intraoperative thoracic surgery in a single institution (Istanbul, Turkey).
Methods
All 197 subsequent patient specimens (cases) from 158 patients who were sent to our department from the thoracic surgery clinic for an intraoperative diagnosis request between the years 2016 and 2021 were evaluated. Obtained results from frozen and cytology were compared with final paraffin section diagnoses. Lesions were grouped into three different groups as nonneoplastic, benign, and malignant neoplasms.
Results
Diagnostic accuracy values of cytology and frozen sections in intraoperative consultation were 98.8% and 99.4%, respectively. Sensitivity values of cytology and frozen sections in intraoperative consultation were 96.3% and 98.7%, respectively. Specificity values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Negative predictive values of cytology and frozen sections in intraoperative consultation were 96.7% and 98.9%, respectively. Positive predictive values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Kappa statistics between cytology and frozen revealed a very high interrater reliability (Cohen's Kappa value: 0.911; p = .001; p < .01). The difficulty in distinguishing primary and metastatic carcinoma, which is mostly undecided in frozen sections and the definitive diagnosis is left to paraffin sections, seems also be a problem in the cytological examination.
Conclusions
Cytological diagnosis can be used in the evaluation of small biopsy specimens that require tissue preservation in intraoperative consultation, especially for immunohistochemical and advanced genetic studies.</description><identifier>ISSN: 8755-1039</identifier><identifier>EISSN: 1097-0339</identifier><identifier>DOI: 10.1002/dc.25060</identifier><identifier>PMID: 36181474</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Carcinoma ; Cellular biology ; Developing Countries ; Frozen Sections - methods ; Humans ; intraoperative diagnosis ; Intraoperative Period ; Paraffin ; pulmonary pathology ; Reproducibility of Results ; scratch‐imprint cytology ; Sensitivity and Specificity ; Thoracic surgery</subject><ispartof>Diagnostic cytopathology, 2023-02, Vol.51 (2), p.123-134</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3100-bdabb6ac8e07b6367c227535673d3c7b2170c2b5c5223311624c7b19bb522aeb3</cites><orcidid>0000-0002-6586-8092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdc.25060$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdc.25060$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36181474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silav, Zuhal Kuş</creatorcontrib><creatorcontrib>Sönmez, Cansu</creatorcontrib><creatorcontrib>Aydemir, Bülent</creatorcontrib><creatorcontrib>Yıldırım, Mehmet</creatorcontrib><creatorcontrib>Okay, Tamer</creatorcontrib><creatorcontrib>Aker, Fügen Vardar</creatorcontrib><title>Could cytology supplant frozen section for intraoperative evaluation of thoracic lesions? A single institutional experience in a developing country</title><title>Diagnostic cytopathology</title><addtitle>Diagn Cytopathol</addtitle><description>Background
The diagnostic performance of cytology was compared with the frozen results and its usability was evaluated as a rapid diagnosis method in intraoperative thoracic surgery in a single institution (Istanbul, Turkey).
Methods
All 197 subsequent patient specimens (cases) from 158 patients who were sent to our department from the thoracic surgery clinic for an intraoperative diagnosis request between the years 2016 and 2021 were evaluated. Obtained results from frozen and cytology were compared with final paraffin section diagnoses. Lesions were grouped into three different groups as nonneoplastic, benign, and malignant neoplasms.
Results
Diagnostic accuracy values of cytology and frozen sections in intraoperative consultation were 98.8% and 99.4%, respectively. Sensitivity values of cytology and frozen sections in intraoperative consultation were 96.3% and 98.7%, respectively. Specificity values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Negative predictive values of cytology and frozen sections in intraoperative consultation were 96.7% and 98.9%, respectively. Positive predictive values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Kappa statistics between cytology and frozen revealed a very high interrater reliability (Cohen's Kappa value: 0.911; p = .001; p < .01). The difficulty in distinguishing primary and metastatic carcinoma, which is mostly undecided in frozen sections and the definitive diagnosis is left to paraffin sections, seems also be a problem in the cytological examination.
Conclusions
Cytological diagnosis can be used in the evaluation of small biopsy specimens that require tissue preservation in intraoperative consultation, especially for immunohistochemical and advanced genetic studies.</description><subject>Carcinoma</subject><subject>Cellular biology</subject><subject>Developing Countries</subject><subject>Frozen Sections - methods</subject><subject>Humans</subject><subject>intraoperative diagnosis</subject><subject>Intraoperative Period</subject><subject>Paraffin</subject><subject>pulmonary pathology</subject><subject>Reproducibility of Results</subject><subject>scratch‐imprint cytology</subject><subject>Sensitivity and Specificity</subject><subject>Thoracic surgery</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctq3DAUhkVpaaZJoE9QBN1046kuI8telTC9JBDopl0bST5OFDSWq8sk7mvkhau5pIFCV4L_fPrEr4PQW0qWlBD2sTdLJkhNXqAFJa2sCOftS7RopBAVJbw9QW9ivCOEtIzWr9EJr2lDV3K1QI9rn12PzZy88zczjnmanBoTHoL_DSOOYJL1Ix58wHZMQfkJgkp2Cxi2ymW1n_oBp1sflLEGO4glip_wBY52vHFQ7sVkU96RymF4KAYLo9kNsMI9bMH5qaDY-FyemM_Qq0G5COfH8xT9_Prlx_qyuv7-7Wp9cV0ZXlpXulda18o0QKSueS0NY1JwUUvecyM1o5IYpoURjHFOac1WJaWt1iVQoPkp-nDwTsH_yhBTt7HRgCv9wefYMcnIipfvYwV9_w9653ModXaUaJtGSNE8C03wMQYYuinYjQpzR0m3W1TXm26_qIK-Owqz3kD_F3zaTAGqA3BvHcz_FXWf1wfhH-uuniA</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Silav, Zuhal Kuş</creator><creator>Sönmez, Cansu</creator><creator>Aydemir, Bülent</creator><creator>Yıldırım, Mehmet</creator><creator>Okay, Tamer</creator><creator>Aker, Fügen Vardar</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6586-8092</orcidid></search><sort><creationdate>202302</creationdate><title>Could cytology supplant frozen section for intraoperative evaluation of thoracic lesions? A single institutional experience in a developing country</title><author>Silav, Zuhal Kuş ; Sönmez, Cansu ; Aydemir, Bülent ; Yıldırım, Mehmet ; Okay, Tamer ; Aker, Fügen Vardar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3100-bdabb6ac8e07b6367c227535673d3c7b2170c2b5c5223311624c7b19bb522aeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carcinoma</topic><topic>Cellular biology</topic><topic>Developing Countries</topic><topic>Frozen Sections - methods</topic><topic>Humans</topic><topic>intraoperative diagnosis</topic><topic>Intraoperative Period</topic><topic>Paraffin</topic><topic>pulmonary pathology</topic><topic>Reproducibility of Results</topic><topic>scratch‐imprint cytology</topic><topic>Sensitivity and Specificity</topic><topic>Thoracic surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silav, Zuhal Kuş</creatorcontrib><creatorcontrib>Sönmez, Cansu</creatorcontrib><creatorcontrib>Aydemir, Bülent</creatorcontrib><creatorcontrib>Yıldırım, Mehmet</creatorcontrib><creatorcontrib>Okay, Tamer</creatorcontrib><creatorcontrib>Aker, Fügen Vardar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silav, Zuhal Kuş</au><au>Sönmez, Cansu</au><au>Aydemir, Bülent</au><au>Yıldırım, Mehmet</au><au>Okay, Tamer</au><au>Aker, Fügen Vardar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Could cytology supplant frozen section for intraoperative evaluation of thoracic lesions? A single institutional experience in a developing country</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn Cytopathol</addtitle><date>2023-02</date><risdate>2023</risdate><volume>51</volume><issue>2</issue><spage>123</spage><epage>134</epage><pages>123-134</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><abstract>Background
The diagnostic performance of cytology was compared with the frozen results and its usability was evaluated as a rapid diagnosis method in intraoperative thoracic surgery in a single institution (Istanbul, Turkey).
Methods
All 197 subsequent patient specimens (cases) from 158 patients who were sent to our department from the thoracic surgery clinic for an intraoperative diagnosis request between the years 2016 and 2021 were evaluated. Obtained results from frozen and cytology were compared with final paraffin section diagnoses. Lesions were grouped into three different groups as nonneoplastic, benign, and malignant neoplasms.
Results
Diagnostic accuracy values of cytology and frozen sections in intraoperative consultation were 98.8% and 99.4%, respectively. Sensitivity values of cytology and frozen sections in intraoperative consultation were 96.3% and 98.7%, respectively. Specificity values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Negative predictive values of cytology and frozen sections in intraoperative consultation were 96.7% and 98.9%, respectively. Positive predictive values of cytology and frozen sections in intraoperative consultation were 100% and 100%, respectively. Kappa statistics between cytology and frozen revealed a very high interrater reliability (Cohen's Kappa value: 0.911; p = .001; p < .01). The difficulty in distinguishing primary and metastatic carcinoma, which is mostly undecided in frozen sections and the definitive diagnosis is left to paraffin sections, seems also be a problem in the cytological examination.
Conclusions
Cytological diagnosis can be used in the evaluation of small biopsy specimens that require tissue preservation in intraoperative consultation, especially for immunohistochemical and advanced genetic studies.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>36181474</pmid><doi>10.1002/dc.25060</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6586-8092</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8755-1039 |
| ispartof | Diagnostic cytopathology, 2023-02, Vol.51 (2), p.123-134 |
| issn | 8755-1039 1097-0339 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2720430392 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Carcinoma Cellular biology Developing Countries Frozen Sections - methods Humans intraoperative diagnosis Intraoperative Period Paraffin pulmonary pathology Reproducibility of Results scratch‐imprint cytology Sensitivity and Specificity Thoracic surgery |
| title | Could cytology supplant frozen section for intraoperative evaluation of thoracic lesions? A single institutional experience in a developing country |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T00%3A24%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Could%20cytology%20supplant%20frozen%20section%20for%20intraoperative%20evaluation%20of%20thoracic%20lesions?%20A%20single%20institutional%20experience%20in%20a%20developing%20country&rft.jtitle=Diagnostic%20cytopathology&rft.au=Silav,%20Zuhal%20Ku%C5%9F&rft.date=2023-02&rft.volume=51&rft.issue=2&rft.spage=123&rft.epage=134&rft.pages=123-134&rft.issn=8755-1039&rft.eissn=1097-0339&rft_id=info:doi/10.1002/dc.25060&rft_dat=%3Cproquest_cross%3E2759885758%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2759885758&rft_id=info:pmid/36181474&rfr_iscdi=true |