Mitochondrial peptide Mtln contributes to oxidative metabolism in mice
Mitoregulin (Mtln) is a recently identified 56 amino acid long mitochondrial peptide conserved in vertebrates. Mtln is known to enhance function of respiratory complex I, which is likely mediated by modulation of lipid composition. To address an influence of Mtln gene on the metabolism we created kn...
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| Veröffentlicht in: | Biochimie 2023-01, Vol.204, p.136-139 |
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| creator | Averina, Olga A. Permyakov, Oleg A. Emelianova, Mariia A. Grigoryeva, Olga O. Gulyaev, Mikhail V. Pavlova, Olga S. Mariasina, Sofia S. Frolova, Olga Yu Kurkina, Marina V. Baydakova, Galina V. Zakharova, Ekaterina Yu Marey, Maria V. Tsarev, Dmitry A. Tashlitsky, Vadim N. Popov, Vladimir S. Lovat, Maxim L. Polshakov, Vladimir I. Vyssokikh, Mikhail Yu Sergiev, Petr V. |
| description | Mitoregulin (Mtln) is a recently identified 56 amino acid long mitochondrial peptide conserved in vertebrates. Mtln is known to enhance function of respiratory complex I, which is likely mediated by modulation of lipid composition. To address an influence of Mtln gene on the metabolism we created knockout mice deficient in Mtln gene. In line with accumulation of triglycerides observed earlier on a model of Mtln knockout cell lines, we observed Mtln KO mice to develop obesity on a high fat diet. An increased weight gain could be attributed to enhanced fat accumulation according to the magnetic resonance live imaging. In addition, Mtln KO mice demonstrate elevated serum triglycerides and other oxidation substrates accompanied by an exhaustion of tricarboxylic acids cycle intermediates, suggesting suboptimal oxidation of respiration substrates by mitochondria lacking Mtln. |
| doi_str_mv | 10.1016/j.biochi.2022.09.009 |
| format | Article |
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Mtln is known to enhance function of respiratory complex I, which is likely mediated by modulation of lipid composition. To address an influence of Mtln gene on the metabolism we created knockout mice deficient in Mtln gene. In line with accumulation of triglycerides observed earlier on a model of Mtln knockout cell lines, we observed Mtln KO mice to develop obesity on a high fat diet. An increased weight gain could be attributed to enhanced fat accumulation according to the magnetic resonance live imaging. In addition, Mtln KO mice demonstrate elevated serum triglycerides and other oxidation substrates accompanied by an exhaustion of tricarboxylic acids cycle intermediates, suggesting suboptimal oxidation of respiration substrates by mitochondria lacking Mtln.</description><identifier>ISSN: 0300-9084</identifier><identifier>EISSN: 1638-6183</identifier><identifier>DOI: 10.1016/j.biochi.2022.09.009</identifier><identifier>PMID: 36174793</identifier><language>eng</language><publisher>France: Elsevier B.V</publisher><subject>Animals ; Diet, High-Fat - adverse effects ; Lipid Metabolism ; Metabolism ; Mice ; Mice, Knockout ; Mitochondria ; Mitochondria - metabolism ; Oxidative phosphorylation ; Oxidative Stress ; Peptides - metabolism ; Short open reading frame ; Small peptide ; Triglycerides - metabolism ; Weight Gain</subject><ispartof>Biochimie, 2023-01, Vol.204, p.136-139</ispartof><rights>2022 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)</rights><rights>Copyright © 2022 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-9b948c045ea2a8d1d03bda1c7239b0954af7cd25b8fd1b9b7fd6b9b897e725073</citedby><cites>FETCH-LOGICAL-c362t-9b948c045ea2a8d1d03bda1c7239b0954af7cd25b8fd1b9b7fd6b9b897e725073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biochi.2022.09.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36174793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Averina, Olga A.</creatorcontrib><creatorcontrib>Permyakov, Oleg A.</creatorcontrib><creatorcontrib>Emelianova, Mariia A.</creatorcontrib><creatorcontrib>Grigoryeva, Olga O.</creatorcontrib><creatorcontrib>Gulyaev, Mikhail V.</creatorcontrib><creatorcontrib>Pavlova, Olga S.</creatorcontrib><creatorcontrib>Mariasina, Sofia S.</creatorcontrib><creatorcontrib>Frolova, Olga Yu</creatorcontrib><creatorcontrib>Kurkina, Marina V.</creatorcontrib><creatorcontrib>Baydakova, Galina V.</creatorcontrib><creatorcontrib>Zakharova, Ekaterina Yu</creatorcontrib><creatorcontrib>Marey, Maria V.</creatorcontrib><creatorcontrib>Tsarev, Dmitry A.</creatorcontrib><creatorcontrib>Tashlitsky, Vadim N.</creatorcontrib><creatorcontrib>Popov, Vladimir S.</creatorcontrib><creatorcontrib>Lovat, Maxim L.</creatorcontrib><creatorcontrib>Polshakov, Vladimir I.</creatorcontrib><creatorcontrib>Vyssokikh, Mikhail Yu</creatorcontrib><creatorcontrib>Sergiev, Petr V.</creatorcontrib><title>Mitochondrial peptide Mtln contributes to oxidative metabolism in mice</title><title>Biochimie</title><addtitle>Biochimie</addtitle><description>Mitoregulin (Mtln) is a recently identified 56 amino acid long mitochondrial peptide conserved in vertebrates. Mtln is known to enhance function of respiratory complex I, which is likely mediated by modulation of lipid composition. To address an influence of Mtln gene on the metabolism we created knockout mice deficient in Mtln gene. In line with accumulation of triglycerides observed earlier on a model of Mtln knockout cell lines, we observed Mtln KO mice to develop obesity on a high fat diet. An increased weight gain could be attributed to enhanced fat accumulation according to the magnetic resonance live imaging. In addition, Mtln KO mice demonstrate elevated serum triglycerides and other oxidation substrates accompanied by an exhaustion of tricarboxylic acids cycle intermediates, suggesting suboptimal oxidation of respiration substrates by mitochondria lacking Mtln.</description><subject>Animals</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Lipid Metabolism</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Oxidative phosphorylation</subject><subject>Oxidative Stress</subject><subject>Peptides - metabolism</subject><subject>Short open reading frame</subject><subject>Small peptide</subject><subject>Triglycerides - metabolism</subject><subject>Weight Gain</subject><issn>0300-9084</issn><issn>1638-6183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3TAQRa0KVB60_6CqsmSTdGwncbxBqlCBSiA2dG35Y6LOUxI_bD8E_75Bj7JkNZtz79Ucxr5xaDjw_se2cRT9X2oECNGAbgD0J7bhvRzqng_yiG1AAtQahvaEnea8BYAOhP7MTmTPVau03LCrOyprS1xCIjtVO9wVCljdlWmpfFxKIrcvmKsSq_hMwRZ6wmrGYl2cKM8VLdVMHr-w49FOGb--3TP25-rXw-VNfXt__fvy523tZS9KrZ1uBw9th1bYIfAA0gXLvRJSO9Bda0flg-jcMAbutFNj6NczaIVKdKDkGTs_9O5SfNxjLmam7HGa7IJxn41QAlrRtd2wou0B9SnmnHA0u0SzTS-Gg3k1aLbmYNC8GjSgzWpwjX1_W9i7GcN76L-yFbg4ALj--USYTPaEi8dACX0xIdLHC_8AKz2ETg</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Averina, Olga A.</creator><creator>Permyakov, Oleg A.</creator><creator>Emelianova, Mariia A.</creator><creator>Grigoryeva, Olga O.</creator><creator>Gulyaev, Mikhail V.</creator><creator>Pavlova, Olga S.</creator><creator>Mariasina, Sofia S.</creator><creator>Frolova, Olga Yu</creator><creator>Kurkina, Marina V.</creator><creator>Baydakova, Galina V.</creator><creator>Zakharova, Ekaterina Yu</creator><creator>Marey, Maria V.</creator><creator>Tsarev, Dmitry A.</creator><creator>Tashlitsky, Vadim N.</creator><creator>Popov, Vladimir S.</creator><creator>Lovat, Maxim L.</creator><creator>Polshakov, Vladimir I.</creator><creator>Vyssokikh, Mikhail Yu</creator><creator>Sergiev, Petr V.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202301</creationdate><title>Mitochondrial peptide Mtln contributes to oxidative metabolism in mice</title><author>Averina, Olga A. ; Permyakov, Oleg A. ; Emelianova, Mariia A. ; Grigoryeva, Olga O. ; Gulyaev, Mikhail V. ; Pavlova, Olga S. ; Mariasina, Sofia S. ; Frolova, Olga Yu ; Kurkina, Marina V. ; Baydakova, Galina V. ; Zakharova, Ekaterina Yu ; Marey, Maria V. ; Tsarev, Dmitry A. ; Tashlitsky, Vadim N. ; Popov, Vladimir S. ; Lovat, Maxim L. ; Polshakov, Vladimir I. ; Vyssokikh, Mikhail Yu ; Sergiev, Petr V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-9b948c045ea2a8d1d03bda1c7239b0954af7cd25b8fd1b9b7fd6b9b897e725073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Lipid Metabolism</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mitochondria</topic><topic>Mitochondria - metabolism</topic><topic>Oxidative phosphorylation</topic><topic>Oxidative Stress</topic><topic>Peptides - metabolism</topic><topic>Short open reading frame</topic><topic>Small peptide</topic><topic>Triglycerides - metabolism</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Averina, Olga A.</creatorcontrib><creatorcontrib>Permyakov, Oleg A.</creatorcontrib><creatorcontrib>Emelianova, Mariia A.</creatorcontrib><creatorcontrib>Grigoryeva, Olga O.</creatorcontrib><creatorcontrib>Gulyaev, Mikhail V.</creatorcontrib><creatorcontrib>Pavlova, Olga S.</creatorcontrib><creatorcontrib>Mariasina, Sofia S.</creatorcontrib><creatorcontrib>Frolova, Olga Yu</creatorcontrib><creatorcontrib>Kurkina, Marina V.</creatorcontrib><creatorcontrib>Baydakova, Galina V.</creatorcontrib><creatorcontrib>Zakharova, Ekaterina Yu</creatorcontrib><creatorcontrib>Marey, Maria V.</creatorcontrib><creatorcontrib>Tsarev, Dmitry A.</creatorcontrib><creatorcontrib>Tashlitsky, Vadim N.</creatorcontrib><creatorcontrib>Popov, Vladimir S.</creatorcontrib><creatorcontrib>Lovat, Maxim L.</creatorcontrib><creatorcontrib>Polshakov, Vladimir I.</creatorcontrib><creatorcontrib>Vyssokikh, Mikhail Yu</creatorcontrib><creatorcontrib>Sergiev, Petr V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Averina, Olga A.</au><au>Permyakov, Oleg A.</au><au>Emelianova, Mariia A.</au><au>Grigoryeva, Olga O.</au><au>Gulyaev, Mikhail V.</au><au>Pavlova, Olga S.</au><au>Mariasina, Sofia S.</au><au>Frolova, Olga Yu</au><au>Kurkina, Marina V.</au><au>Baydakova, Galina V.</au><au>Zakharova, Ekaterina Yu</au><au>Marey, Maria V.</au><au>Tsarev, Dmitry A.</au><au>Tashlitsky, Vadim N.</au><au>Popov, Vladimir S.</au><au>Lovat, Maxim L.</au><au>Polshakov, Vladimir I.</au><au>Vyssokikh, Mikhail Yu</au><au>Sergiev, Petr V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondrial peptide Mtln contributes to oxidative metabolism in mice</atitle><jtitle>Biochimie</jtitle><addtitle>Biochimie</addtitle><date>2023-01</date><risdate>2023</risdate><volume>204</volume><spage>136</spage><epage>139</epage><pages>136-139</pages><issn>0300-9084</issn><eissn>1638-6183</eissn><abstract>Mitoregulin (Mtln) is a recently identified 56 amino acid long mitochondrial peptide conserved in vertebrates. Mtln is known to enhance function of respiratory complex I, which is likely mediated by modulation of lipid composition. To address an influence of Mtln gene on the metabolism we created knockout mice deficient in Mtln gene. In line with accumulation of triglycerides observed earlier on a model of Mtln knockout cell lines, we observed Mtln KO mice to develop obesity on a high fat diet. An increased weight gain could be attributed to enhanced fat accumulation according to the magnetic resonance live imaging. In addition, Mtln KO mice demonstrate elevated serum triglycerides and other oxidation substrates accompanied by an exhaustion of tricarboxylic acids cycle intermediates, suggesting suboptimal oxidation of respiration substrates by mitochondria lacking Mtln.</abstract><cop>France</cop><pub>Elsevier B.V</pub><pmid>36174793</pmid><doi>10.1016/j.biochi.2022.09.009</doi><tpages>4</tpages></addata></record> |
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| ispartof | Biochimie, 2023-01, Vol.204, p.136-139 |
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| subjects | Animals Diet, High-Fat - adverse effects Lipid Metabolism Metabolism Mice Mice, Knockout Mitochondria Mitochondria - metabolism Oxidative phosphorylation Oxidative Stress Peptides - metabolism Short open reading frame Small peptide Triglycerides - metabolism Weight Gain |
| title | Mitochondrial peptide Mtln contributes to oxidative metabolism in mice |
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