Achievements and perspectives of synthetic biology in botanical insecticides
Botanical insecticides are the origin of all insecticidal compounds. They have been widely used to control pests in crops for a long time. Currently, the commercial production of botanical insecticides extracted from plants is limited because of insufficient raw material supply. Synthetic biology is...
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| Veröffentlicht in: | Journal of cellular physiology 2024-10, Vol.239 (10), p.e30888-n/a |
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| container_title | Journal of cellular physiology |
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| creator | Wang, Shengli Zhan, Chuanling Chen, Ruiqi Li, Weiguo Song, Hongjian Zhao, Guangrong Wen, Mingzhang Liang, Dongmei Qiao, Jianjun |
| description | Botanical insecticides are the origin of all insecticidal compounds. They have been widely used to control pests in crops for a long time. Currently, the commercial production of botanical insecticides extracted from plants is limited because of insufficient raw material supply. Synthetic biology is a promising and effective approach for addressing the current problems of the production of botanical insecticides. It is an emerging biological research hotspot in the field of botanical insecticides. However, the biosynthetic pathways of many botanical insecticides are not completely elucidated. On the other hand, the cytotoxicity of botanical pesticides and low efficiency of these biosynthetic enzymes in new hosts make it still challenging for their heterologous production. In the present review, we summarized the recent developments in the heterologous production of botanical insecticides, analyzed the current challenges, and discussed the feasible production strategies, focusing on elucidating biosynthetic pathways, enzyme engineering, host engineering, and cytotoxicity engineering. Looking to the future, synthetic biology promises to further advance heterologous production of more botanical pesticides. |
| doi_str_mv | 10.1002/jcp.30888 |
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They have been widely used to control pests in crops for a long time. Currently, the commercial production of botanical insecticides extracted from plants is limited because of insufficient raw material supply. Synthetic biology is a promising and effective approach for addressing the current problems of the production of botanical insecticides. It is an emerging biological research hotspot in the field of botanical insecticides. However, the biosynthetic pathways of many botanical insecticides are not completely elucidated. On the other hand, the cytotoxicity of botanical pesticides and low efficiency of these biosynthetic enzymes in new hosts make it still challenging for their heterologous production. In the present review, we summarized the recent developments in the heterologous production of botanical insecticides, analyzed the current challenges, and discussed the feasible production strategies, focusing on elucidating biosynthetic pathways, enzyme engineering, host engineering, and cytotoxicity engineering. Looking to the future, synthetic biology promises to further advance heterologous production of more botanical pesticides.</description><identifier>ISSN: 0021-9541</identifier><identifier>ISSN: 1097-4652</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.30888</identifier><identifier>PMID: 36183373</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Biological effects ; Biological research ; Biology ; biosynthetic pathways ; Biosynthetic Pathways - drug effects ; botanical insecticides ; Crop production ; Cytotoxicity ; cytotoxicity engineering ; enzyme engineering ; host engineering ; Humans ; Insecticides ; Insecticides - pharmacology ; Metabolic Engineering - methods ; Pest control ; Pesticides ; Pests ; Plant extracts ; Plant layout ; Raw materials ; Synthetic biology ; Synthetic Biology - methods ; Toxicity</subject><ispartof>Journal of cellular physiology, 2024-10, Vol.239 (10), p.e30888-n/a</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3538-7e9bd7380ca96f91a0d21e359b03b6060d23cf9a60c6fb2ff6c259e5943759d33</citedby><cites>FETCH-LOGICAL-c3538-7e9bd7380ca96f91a0d21e359b03b6060d23cf9a60c6fb2ff6c259e5943759d33</cites><orcidid>0000-0002-0334-439X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.30888$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.30888$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36183373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shengli</creatorcontrib><creatorcontrib>Zhan, Chuanling</creatorcontrib><creatorcontrib>Chen, Ruiqi</creatorcontrib><creatorcontrib>Li, Weiguo</creatorcontrib><creatorcontrib>Song, Hongjian</creatorcontrib><creatorcontrib>Zhao, Guangrong</creatorcontrib><creatorcontrib>Wen, Mingzhang</creatorcontrib><creatorcontrib>Liang, Dongmei</creatorcontrib><creatorcontrib>Qiao, Jianjun</creatorcontrib><title>Achievements and perspectives of synthetic biology in botanical insecticides</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Botanical insecticides are the origin of all insecticidal compounds. They have been widely used to control pests in crops for a long time. Currently, the commercial production of botanical insecticides extracted from plants is limited because of insufficient raw material supply. Synthetic biology is a promising and effective approach for addressing the current problems of the production of botanical insecticides. It is an emerging biological research hotspot in the field of botanical insecticides. However, the biosynthetic pathways of many botanical insecticides are not completely elucidated. On the other hand, the cytotoxicity of botanical pesticides and low efficiency of these biosynthetic enzymes in new hosts make it still challenging for their heterologous production. In the present review, we summarized the recent developments in the heterologous production of botanical insecticides, analyzed the current challenges, and discussed the feasible production strategies, focusing on elucidating biosynthetic pathways, enzyme engineering, host engineering, and cytotoxicity engineering. Looking to the future, synthetic biology promises to further advance heterologous production of more botanical pesticides.</description><subject>Animals</subject><subject>Biological effects</subject><subject>Biological research</subject><subject>Biology</subject><subject>biosynthetic pathways</subject><subject>Biosynthetic Pathways - drug effects</subject><subject>botanical insecticides</subject><subject>Crop production</subject><subject>Cytotoxicity</subject><subject>cytotoxicity engineering</subject><subject>enzyme engineering</subject><subject>host engineering</subject><subject>Humans</subject><subject>Insecticides</subject><subject>Insecticides - pharmacology</subject><subject>Metabolic Engineering - methods</subject><subject>Pest control</subject><subject>Pesticides</subject><subject>Pests</subject><subject>Plant extracts</subject><subject>Plant layout</subject><subject>Raw materials</subject><subject>Synthetic biology</subject><subject>Synthetic Biology - methods</subject><subject>Toxicity</subject><issn>0021-9541</issn><issn>1097-4652</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1Lw0AQBuBFFFurB_-ABLzoIXZ3J9lkj6X4SUEPel42m4ndki-zaaX_3q2pHgRPwzAPL8NLyDmjN4xSPl2Z9gZomqYHZMyoTMJIxPyQjP2NhTKO2IicOLeilEoJcExGIFgKkMCYLGZmaXGDFda9C3SdBy12rkXT2w26oCkCt637JfbWBJltyuZ9G9g6yJpe19bo0i9uh43N0Z2So0KXDs_2c0Le7m5f5w_h4vn-cT5bhAZiSMMEZZYnkFKjpSgk0zTnDCGWGYVMUOFXMIXUghpRZLwohOGxxFhGkMQyB5iQqyG37ZqPNbpeVdYZLEtdY7N2iiecRjwSEHl6-YeumnVX--8UMBYLziQVXl0PynSNcx0Wqu1spbutYlTtKla-YvVdsbcX-8R1VmH-K3869WA6gE9b4vb_JPU0fxkivwD8VYS_</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Wang, Shengli</creator><creator>Zhan, Chuanling</creator><creator>Chen, Ruiqi</creator><creator>Li, Weiguo</creator><creator>Song, Hongjian</creator><creator>Zhao, Guangrong</creator><creator>Wen, Mingzhang</creator><creator>Liang, Dongmei</creator><creator>Qiao, Jianjun</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0334-439X</orcidid></search><sort><creationdate>202410</creationdate><title>Achievements and perspectives of synthetic biology in botanical insecticides</title><author>Wang, Shengli ; Zhan, Chuanling ; Chen, Ruiqi ; Li, Weiguo ; Song, Hongjian ; Zhao, Guangrong ; Wen, Mingzhang ; Liang, Dongmei ; Qiao, Jianjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3538-7e9bd7380ca96f91a0d21e359b03b6060d23cf9a60c6fb2ff6c259e5943759d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Biological effects</topic><topic>Biological research</topic><topic>Biology</topic><topic>biosynthetic pathways</topic><topic>Biosynthetic Pathways - drug effects</topic><topic>botanical insecticides</topic><topic>Crop production</topic><topic>Cytotoxicity</topic><topic>cytotoxicity engineering</topic><topic>enzyme engineering</topic><topic>host engineering</topic><topic>Humans</topic><topic>Insecticides</topic><topic>Insecticides - pharmacology</topic><topic>Metabolic Engineering - methods</topic><topic>Pest control</topic><topic>Pesticides</topic><topic>Pests</topic><topic>Plant extracts</topic><topic>Plant layout</topic><topic>Raw materials</topic><topic>Synthetic biology</topic><topic>Synthetic Biology - methods</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shengli</creatorcontrib><creatorcontrib>Zhan, Chuanling</creatorcontrib><creatorcontrib>Chen, Ruiqi</creatorcontrib><creatorcontrib>Li, Weiguo</creatorcontrib><creatorcontrib>Song, Hongjian</creatorcontrib><creatorcontrib>Zhao, Guangrong</creatorcontrib><creatorcontrib>Wen, Mingzhang</creatorcontrib><creatorcontrib>Liang, Dongmei</creatorcontrib><creatorcontrib>Qiao, Jianjun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shengli</au><au>Zhan, Chuanling</au><au>Chen, Ruiqi</au><au>Li, Weiguo</au><au>Song, Hongjian</au><au>Zhao, Guangrong</au><au>Wen, Mingzhang</au><au>Liang, Dongmei</au><au>Qiao, Jianjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Achievements and perspectives of synthetic biology in botanical insecticides</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2024-10</date><risdate>2024</risdate><volume>239</volume><issue>10</issue><spage>e30888</spage><epage>n/a</epage><pages>e30888-n/a</pages><issn>0021-9541</issn><issn>1097-4652</issn><eissn>1097-4652</eissn><abstract>Botanical insecticides are the origin of all insecticidal compounds. They have been widely used to control pests in crops for a long time. Currently, the commercial production of botanical insecticides extracted from plants is limited because of insufficient raw material supply. Synthetic biology is a promising and effective approach for addressing the current problems of the production of botanical insecticides. It is an emerging biological research hotspot in the field of botanical insecticides. However, the biosynthetic pathways of many botanical insecticides are not completely elucidated. On the other hand, the cytotoxicity of botanical pesticides and low efficiency of these biosynthetic enzymes in new hosts make it still challenging for their heterologous production. In the present review, we summarized the recent developments in the heterologous production of botanical insecticides, analyzed the current challenges, and discussed the feasible production strategies, focusing on elucidating biosynthetic pathways, enzyme engineering, host engineering, and cytotoxicity engineering. Looking to the future, synthetic biology promises to further advance heterologous production of more botanical pesticides.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36183373</pmid><doi>10.1002/jcp.30888</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-0334-439X</orcidid></addata></record> |
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| subjects | Animals Biological effects Biological research Biology biosynthetic pathways Biosynthetic Pathways - drug effects botanical insecticides Crop production Cytotoxicity cytotoxicity engineering enzyme engineering host engineering Humans Insecticides Insecticides - pharmacology Metabolic Engineering - methods Pest control Pesticides Pests Plant extracts Plant layout Raw materials Synthetic biology Synthetic Biology - methods Toxicity |
| title | Achievements and perspectives of synthetic biology in botanical insecticides |
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