Albumin fusion with human lactoferrin shows enhanced inhibition of cancer cell migration

The fusion of human serum albumin (HSA) with human lactoferrin (hLF) (designated as hLF-HSA) has improved the pharmacokinetic properties and anti-proliferative activities of hLF against cancer cells. In this study, we evaluated the anti-migratory activities of hLF and hLF-HSA against the human lung...

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Veröffentlicht in:	Biometals 2023-06, Vol.36 (3), p.629-638
Hauptverfasser:	Nopia, Hana, Kurimoto, Daisuke, Sato, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Albumin Albumins - genetics Albumins - therapeutic use Antitumor agents Biochemistry Biomedical and Life Sciences Boyden chamber Cancer Cell adhesion & migration Cell Biology Cell fusion Cell migration Cell Movement Down-Regulation Drug development Gelatinase B Human serum albumin Humans Lactoferrin Lactoferrin - genetics Lactoferrin - therapeutic use Life Sciences Lung cancer Matrix metalloproteinase Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Matrix metalloproteinases Medicine/Public Health Metalloproteinase Metastases Microbiology Neoplasms - therapy Pharmacokinetics Pharmacology/Toxicology Plant Physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - therapeutic use Serum albumin Wound healing
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