Acetate accumulation and regulation by process parameters control in Chinese hamster ovary cell culture

Chinese hamster ovary (CHO) cells represent a group of predominantly used mammalian hosts for producing recombinant therapeutic proteins. Known for their rapid proliferation rates, CHO cells undergo aerobic glycolysis that is characterized by fast glucose consumption, that ultimately gives rise to a...

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Veröffentlicht in:	Biotechnology progress 2023-01, Vol.39 (1), p.e3303-n/a
Hauptverfasser:	Zhou, Yikang, Han, Hang, Zhang, Lijuan, Huang, He, Sun, Ruiqiang, Zhou, Hang, Zhou, Weichang
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation acetate accumulation Acetic acid Acidification Animals Cell culture Cell Culture Techniques - methods Cell lines Cell proliferation CHO cell CHO Cells Consumption Cricetinae Cricetulus Culture media Culture Media - chemistry Culture Media - pharmacology Glucose Glucose - metabolism Glycolysis Lactic acid Lactic Acid - metabolism media acidification Metabolism Organic acids Ovaries Overflow overflow metabolism pH control pH effects Process control Process controls Process parameters Recombinant Proteins - metabolism
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