Modification of cardiac disease by transgenically altered histone deacetylase 6

Histone deacetylase 6 (HDAC6) is known to deacetylate amino acid lysine in alpha-tubulin. However, the functional role of HDAC6 in the progression of cardiac disease remains uncertain. The functional role of HDAC6 in the hearts was examined using transgenic (TG) mice expressing either human wild-typ...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-11, Vol.631, p.48-54
Hauptverfasser:	Sanbe, Atsushi, Inomata, Yui, Matsushita, Naoko, Sawa, Yohei, Hino, Chizuru, Yamazaki, Hinano, Takanohashi, Kei, Takahashi, Natsuko, Higashio, Rieko, Tsumura, Hideki, Aoyagi, Toshinori, Hirose, Masamichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Aspartic Acid - metabolism Cortactin - metabolism HDAC6 Heart Diseases Heart failure Histone Deacetylase 6 - genetics Histone Deacetylase 6 - metabolism Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Hypertrophy Isoproterenol Lysine - metabolism Mice Mice, Transgenic Serine - metabolism Threonine - metabolism Transgenic mouse Tubulin - metabolism
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