Improved quantitation of short-chain carboxylic acids in human biofluids using 3-nitrophenylhydrazine derivatization and liquid chromatography with tandem mass spectrometry (LC-MS/MS)

Short-chain carboxylic acids (SCCAs) produced by gut microbial fermentation may reflect gastrointestinal health. Their concentrations in serum and urine are indicative of specific metabolic pathway activity; therefore, accurate quantitation of SCCAs in different biofluids is desirable. However, it i...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2022-11, Vol.221, p.115060-115060, Article 115060
Hauptverfasser:	Valdivia-Garcia, Maria A., Chappell, Katie E., Camuzeaux, Stephane, Olmo-García, Lucía, van der Sluis, Verena Horneffer, Radhakrishnan, Shiva T., Stephens, Hannah, Bouri, Sonia, de Campos Braz, Lucia M., Williams, Horace T., Lewis, Matthew R., Frost, Gary, Li, Jia V.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-NPH Caproates Carboxylic Acids Chromatography, High Pressure Liquid - methods Chromatography, Liquid - methods Colostomy bag CSH Derivatization Humans Hydroxybutyrates Isobutyrates Lactates Ostomy pouch Phenylhydrazines Propionates Short chain fatty acids Tandem Mass Spectrometry - methods Valerates
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