The correlation between osseointegration and bonding strength at the bone-implant interface: In-vivo & ex-vivo investigations on hydroxyapatite and hydroxyapatite/titanium coatings
This study investigated the effects of hydroxyapatite (HA) and hydroxyapatite/titanium (HA/Ti) coatings on osseointegration and bonding strength at the bone-implant interface. The coatings were made using air plasma spray (APS), and three study groups were examined: 1) Uncoated commercial pure titan...
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| Veröffentlicht in: | Journal of biomechanics 2022-11, Vol.144, p.111310-111310, Article 111310 |
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| creator | Ghadami, Farhad Amani Hamedani, Mohsen Rouhi, Gholamreza Saber-Samandari, Saeed Mehdi Dehghan, Mohammad Farzad-Mohajeri, Saeed Mashhadi-Abbas, Fatemeh |
| description | This study investigated the effects of hydroxyapatite (HA) and hydroxyapatite/titanium (HA/Ti) coatings on osseointegration and bonding strength at the bone-implant interface. The coatings were made using air plasma spray (APS), and three study groups were examined: 1) Uncoated commercial pure titanium (CP-Ti) rods; 2) HA-coated CP-Ti rods, and 3) Composite of 50 %wt HA + 50 %wt Ti coated CP-Ti rods. The rods were implanted into the distal femurs and proximal tibias of fifteen New Zealand white rabbits, and 8 weeks after the implantation, the samples were harvested. The results of pull-out tests showed that the ultimate strength of HA and HA/Ti coatings were significantly greater than the uncoated samples (P |
| doi_str_mv | 10.1016/j.jbiomech.2022.111310 |
| format | Article |
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The coatings were made using air plasma spray (APS), and three study groups were examined: 1) Uncoated commercial pure titanium (CP-Ti) rods; 2) HA-coated CP-Ti rods, and 3) Composite of 50 %wt HA + 50 %wt Ti coated CP-Ti rods. The rods were implanted into the distal femurs and proximal tibias of fifteen New Zealand white rabbits, and 8 weeks after the implantation, the samples were harvested. The results of pull-out tests showed that the ultimate strength of HA and HA/Ti coatings were significantly greater than the uncoated samples (P < 0.05). Moreover, even though the histological evaluations showed significantly greater osseointegration of HA/Ti composite coatings compared with HA coatings (P < 0.05), nonetheless, the composite of HA/Ti offers no significant increase in the ultimate strength, stiffness, and bonding strength at the bone-implant interface, compared with the HA group (P > 0.05). Thus, in an eight-week study, there was no linear correlation between the osseointegration and the bonding strength at the bone-implant interface. The results of this work may imply that the extent of osseointegration at the bone-implant interface does not necessarily determine the value of the bonding strength at the bone-implant interface. It is speculated that, in a longer-term study, a greater quality of bone formation may occur during osseointegration, between the implant and its adjacent bone, which can lead to a more enhanced bonding strength, compared with the 8-weeks post-surgery follow up.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2022.111310</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Air plasma ; Biocompatibility ; Biological activity ; Biomedical materials ; Bonding strength ; Bone growth ; Bone-implant interfaces ; Bones ; Coatings ; Fractures ; HA/Ti coating ; Histology ; Hydroxyapatite ; Investigations ; Mechanical properties ; Orthopedic Biomechanics ; Osseointegration ; Osteogenesis ; Protective coatings ; Pull out tests ; Pull-out test ; Rabbits ; Rods ; Scanning electron microscopy ; Shear strength ; Stiffness ; Surgical implants ; Titanium ; Transplants & implants ; Ultimate tensile strength</subject><ispartof>Journal of biomechanics, 2022-11, Vol.144, p.111310-111310, Article 111310</ispartof><rights>2022 Elsevier Ltd</rights><rights>2022. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-1efda0e436e065eaa17eddcf2e2acbf66db7d62ac18728b63bd47a4ebff86adc3</citedby><cites>FETCH-LOGICAL-c303t-1efda0e436e065eaa17eddcf2e2acbf66db7d62ac18728b63bd47a4ebff86adc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2730671162?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids></links><search><creatorcontrib>Ghadami, Farhad</creatorcontrib><creatorcontrib>Amani Hamedani, Mohsen</creatorcontrib><creatorcontrib>Rouhi, Gholamreza</creatorcontrib><creatorcontrib>Saber-Samandari, Saeed</creatorcontrib><creatorcontrib>Mehdi Dehghan, Mohammad</creatorcontrib><creatorcontrib>Farzad-Mohajeri, Saeed</creatorcontrib><creatorcontrib>Mashhadi-Abbas, Fatemeh</creatorcontrib><title>The correlation between osseointegration and bonding strength at the bone-implant interface: In-vivo & ex-vivo investigations on hydroxyapatite and hydroxyapatite/titanium coatings</title><title>Journal of biomechanics</title><description>This study investigated the effects of hydroxyapatite (HA) and hydroxyapatite/titanium (HA/Ti) coatings on osseointegration and bonding strength at the bone-implant interface. The coatings were made using air plasma spray (APS), and three study groups were examined: 1) Uncoated commercial pure titanium (CP-Ti) rods; 2) HA-coated CP-Ti rods, and 3) Composite of 50 %wt HA + 50 %wt Ti coated CP-Ti rods. The rods were implanted into the distal femurs and proximal tibias of fifteen New Zealand white rabbits, and 8 weeks after the implantation, the samples were harvested. The results of pull-out tests showed that the ultimate strength of HA and HA/Ti coatings were significantly greater than the uncoated samples (P < 0.05). Moreover, even though the histological evaluations showed significantly greater osseointegration of HA/Ti composite coatings compared with HA coatings (P < 0.05), nonetheless, the composite of HA/Ti offers no significant increase in the ultimate strength, stiffness, and bonding strength at the bone-implant interface, compared with the HA group (P > 0.05). Thus, in an eight-week study, there was no linear correlation between the osseointegration and the bonding strength at the bone-implant interface. The results of this work may imply that the extent of osseointegration at the bone-implant interface does not necessarily determine the value of the bonding strength at the bone-implant interface. It is speculated that, in a longer-term study, a greater quality of bone formation may occur during osseointegration, between the implant and its adjacent bone, which can lead to a more enhanced bonding strength, compared with the 8-weeks post-surgery follow up.</description><subject>Air plasma</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Bonding strength</subject><subject>Bone growth</subject><subject>Bone-implant interfaces</subject><subject>Bones</subject><subject>Coatings</subject><subject>Fractures</subject><subject>HA/Ti coating</subject><subject>Histology</subject><subject>Hydroxyapatite</subject><subject>Investigations</subject><subject>Mechanical properties</subject><subject>Orthopedic Biomechanics</subject><subject>Osseointegration</subject><subject>Osteogenesis</subject><subject>Protective coatings</subject><subject>Pull out tests</subject><subject>Pull-out test</subject><subject>Rabbits</subject><subject>Rods</subject><subject>Scanning electron microscopy</subject><subject>Shear strength</subject><subject>Stiffness</subject><subject>Surgical implants</subject><subject>Titanium</subject><subject>Transplants & implants</subject><subject>Ultimate tensile 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investigations on hydroxyapatite and hydroxyapatite/titanium coatings</title><author>Ghadami, Farhad ; Amani Hamedani, Mohsen ; Rouhi, Gholamreza ; Saber-Samandari, Saeed ; Mehdi Dehghan, Mohammad ; Farzad-Mohajeri, Saeed ; Mashhadi-Abbas, Fatemeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-1efda0e436e065eaa17eddcf2e2acbf66db7d62ac18728b63bd47a4ebff86adc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Air plasma</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Biomedical materials</topic><topic>Bonding strength</topic><topic>Bone growth</topic><topic>Bone-implant interfaces</topic><topic>Bones</topic><topic>Coatings</topic><topic>Fractures</topic><topic>HA/Ti coating</topic><topic>Histology</topic><topic>Hydroxyapatite</topic><topic>Investigations</topic><topic>Mechanical properties</topic><topic>Orthopedic Biomechanics</topic><topic>Osseointegration</topic><topic>Osteogenesis</topic><topic>Protective coatings</topic><topic>Pull out tests</topic><topic>Pull-out test</topic><topic>Rabbits</topic><topic>Rods</topic><topic>Scanning electron microscopy</topic><topic>Shear strength</topic><topic>Stiffness</topic><topic>Surgical implants</topic><topic>Titanium</topic><topic>Transplants & implants</topic><topic>Ultimate tensile strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghadami, Farhad</creatorcontrib><creatorcontrib>Amani Hamedani, Mohsen</creatorcontrib><creatorcontrib>Rouhi, Gholamreza</creatorcontrib><creatorcontrib>Saber-Samandari, Saeed</creatorcontrib><creatorcontrib>Mehdi Dehghan, Mohammad</creatorcontrib><creatorcontrib>Farzad-Mohajeri, Saeed</creatorcontrib><creatorcontrib>Mashhadi-Abbas, Fatemeh</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & 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USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomechanics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghadami, Farhad</au><au>Amani Hamedani, Mohsen</au><au>Rouhi, Gholamreza</au><au>Saber-Samandari, Saeed</au><au>Mehdi Dehghan, Mohammad</au><au>Farzad-Mohajeri, Saeed</au><au>Mashhadi-Abbas, Fatemeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The correlation between osseointegration and bonding strength at the bone-implant interface: In-vivo & ex-vivo investigations on hydroxyapatite and hydroxyapatite/titanium coatings</atitle><jtitle>Journal of biomechanics</jtitle><date>2022-11</date><risdate>2022</risdate><volume>144</volume><spage>111310</spage><epage>111310</epage><pages>111310-111310</pages><artnum>111310</artnum><issn>0021-9290</issn><eissn>1873-2380</eissn><abstract>This study investigated the effects of hydroxyapatite (HA) and hydroxyapatite/titanium (HA/Ti) coatings on osseointegration and bonding strength at the bone-implant interface. The coatings were made using air plasma spray (APS), and three study groups were examined: 1) Uncoated commercial pure titanium (CP-Ti) rods; 2) HA-coated CP-Ti rods, and 3) Composite of 50 %wt HA + 50 %wt Ti coated CP-Ti rods. The rods were implanted into the distal femurs and proximal tibias of fifteen New Zealand white rabbits, and 8 weeks after the implantation, the samples were harvested. The results of pull-out tests showed that the ultimate strength of HA and HA/Ti coatings were significantly greater than the uncoated samples (P < 0.05). Moreover, even though the histological evaluations showed significantly greater osseointegration of HA/Ti composite coatings compared with HA coatings (P < 0.05), nonetheless, the composite of HA/Ti offers no significant increase in the ultimate strength, stiffness, and bonding strength at the bone-implant interface, compared with the HA group (P > 0.05). Thus, in an eight-week study, there was no linear correlation between the osseointegration and the bonding strength at the bone-implant interface. The results of this work may imply that the extent of osseointegration at the bone-implant interface does not necessarily determine the value of the bonding strength at the bone-implant interface. It is speculated that, in a longer-term study, a greater quality of bone formation may occur during osseointegration, between the implant and its adjacent bone, which can lead to a more enhanced bonding strength, compared with the 8-weeks post-surgery follow up.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.jbiomech.2022.111310</doi><tpages>1</tpages></addata></record> |
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| subjects | Air plasma Biocompatibility Biological activity Biomedical materials Bonding strength Bone growth Bone-implant interfaces Bones Coatings Fractures HA/Ti coating Histology Hydroxyapatite Investigations Mechanical properties Orthopedic Biomechanics Osseointegration Osteogenesis Protective coatings Pull out tests Pull-out test Rabbits Rods Scanning electron microscopy Shear strength Stiffness Surgical implants Titanium Transplants & implants Ultimate tensile strength |
| title | The correlation between osseointegration and bonding strength at the bone-implant interface: In-vivo & ex-vivo investigations on hydroxyapatite and hydroxyapatite/titanium coatings |
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