Enaminone Formation Drives the Coupling of Biosynthetic Pathways to Generate Cyclic Lipopeptides

A family of novel cyclic lipopeptides named tasikamides A−H (Tsk A−H) were discovered recently in Streptomyces tasikensis P46. Aside from the unique cyclic pentapeptide scaffold shared by the tasikamides, Tsk A−C contain a hydrazone bridge that connects the cyclic pentapeptide to the lipophilic alky...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2022-11, Vol.23 (22), p.e202200457-n/a
Hauptverfasser:	Candra, Hartono, Ma, Guang‐Lei, En, Sean Lee Qiu, Liang, Zhao‐Xun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Aldehydes - metabolism Amines Anti-Bacterial Agents - metabolism beta-keto aldehyde Biosynthetic Pathways Chemical reactions Condensates Coupling enaminone Hydrazones Lipopeptides Lipopeptides - metabolism Lipophilic Microorganisms Multigene Family Organic compounds pathway coupling Peptides, Cyclic - metabolism Scaffolds Streptomyces - metabolism tasikamide
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