Association of Homocysteine and Risks of Long-Term Cardiovascular Events and All-Cause Death among Older Patients with Obstructive Sleep Apnea: A Prospective Study
Objectives This study aimed to assess whether raised baseline plasma tHcy concentrations increased the risks of major adverse cardiovascular events (MACE) and all-cause death outcomes in older patients with obstructive sleep apnea (OSA). Design A multicenter, prospective, observational study. Settin...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2022-09, Vol.26 (9), p.879-888 |
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| creator | Liu, L. Su, X. Zhao, L. Li, J. Xu, W. Yang, L. Yang, Y. Gao, Y. Chen, K. Gao, Y. Guo, J. J. Wang, H. Lin, J. Han, Jiming Fan, Li Fang, Xiangqun |
| description | Objectives
This study aimed to assess whether raised baseline plasma tHcy concentrations increased the risks of major adverse cardiovascular events (MACE) and all-cause death outcomes in older patients with obstructive sleep apnea (OSA).
Design
A multicenter, prospective, observational study.
Setting
Beijing, Shandong Province, Gansu Province of China.
Participants
A total of 1, 290 OSA patients aged 60 to 96 years from sleep centers of six hospitals in China consecutively recruited between January 2015 and October 2017.
Measurements
Cox proportional models assessed the association between tHcy and the risk of new-onset all events among Chinese older OSA patients.
Results
The final analysis (60.1% male; median age, 66 years) used data from 1, 100 subjects during a median follow-up of 42 months, a total of 105 (9.5%) patients developed MACE and 42 (3.8%) patients died. Multivariable Cox regression analysis showed higher adjusted hazard ratios (aHRs) of MACE, myocardial infarction (MI), hospitalization for unstable angina, and composite of all events with tHcy levels in the 4th quartile (HR=5.93, 95% CI: 2.79–12.59; HR=4.72, 95% CI:1.36–4.61; HR=4.26, 95% CI:1.62–5.71; HR=4.17, 95% CI:2.23–7.81) and the 3rd quartile (HR=3.79, 95% CI:1.76–8.20; HR=3.65, 95% CI:1.04–2.98; HR=2.75, 95% CI:1.08–3.76; HR=2.51, 95% CI:1.31–4.83) compared to reference tHcy levels in quartile 1, respectively, while the aHRs (95% CIs) of all-cause death showed significantly higher only in the highest tHcy level quartile than in the lowest quartile (HR=3.20, 95% CI=1.16–8.84, P=0.025) with no significant differences in risks of cardiovascular death and hospitalisation for heart failure among groups (P>0.05).
Conclusions
tHcy, a marker of prognosis for older OSA patients, was significantly associated with the increased risk of MACE and all-cause death in this population independent of BMI, smoking status, and other potential risk factors, but not all clinical components events of MACE. New therapeutic approaches for older patients with OSA should mitigate tHcy-associated risks of MACE, and even all-cause death. |
| doi_str_mv | 10.1007/s12603-022-1840-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2718639142</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2718639142</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-f4c02ab9a2238c677b165924c30a11141001eb64fdd233ba45a6f9c6ba674cdd3</originalsourceid><addsrcrecordid>eNp1kcFu1DAURSNERUvhA9ggS2zYuLUdx07YRUOhlUaaCso6cpyX4pLYwS8ZNN_Dj-LpDCAhsbKle-599rtZ9oqzC86YvkQuFMspE4LyUjKqnmRnXCtGpS7Lp-kudEW1Zvo0e474wJgsqlI9y05zxQulSnaW_awRg3VmdsGT0JPrMAa7wxmcB2J8Rz45_IZ7ZR38Pb2DOJKViZ0LW4N2GUwkV1vwMz7C9TDQlVkQyHsw81dixmQim6GDSG7TjEfwh0vKpsU5LnZ2WyCfB4CJ1JMH847U5DYGnOAozUu3e5Gd9GZAeHk8z7MvH67uVtd0vfl4s6rX1EpezLSXlgnTVkaIvLRK65arohLS5sxwzmVaGYdWyb7rRJ63RhZG9ZVVrVFa2q7Lz7O3h9wphu8L4NyMDi0Mg_EQFmyE5qXKKy5FQt_8gz6EJfr0uj2lc5VWXSSKHyibvoQR-maKbjRx13DW7BtsDg02qcFm32Cjkuf1MXlpR-j-OH5XlgBxADBJ_h7i39H_T_0FKWanQA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2717360455</pqid></control><display><type>article</type><title>Association of Homocysteine and Risks of Long-Term Cardiovascular Events and All-Cause Death among Older Patients with Obstructive Sleep Apnea: A Prospective Study</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Alma/SFX Local Collection</source><creator>Liu, L. ; Su, X. ; Zhao, L. ; Li, J. ; Xu, W. ; Yang, L. ; Yang, Y. ; Gao, Y. ; Chen, K. ; Gao, Y. ; Guo, J. J. ; Wang, H. ; Lin, J. ; Han, Jiming ; Fan, Li ; Fang, Xiangqun</creator><creatorcontrib>Liu, L. ; Su, X. ; Zhao, L. ; Li, J. ; Xu, W. ; Yang, L. ; Yang, Y. ; Gao, Y. ; Chen, K. ; Gao, Y. ; Guo, J. J. ; Wang, H. ; Lin, J. ; Han, Jiming ; Fan, Li ; Fang, Xiangqun</creatorcontrib><description>Objectives
This study aimed to assess whether raised baseline plasma tHcy concentrations increased the risks of major adverse cardiovascular events (MACE) and all-cause death outcomes in older patients with obstructive sleep apnea (OSA).
Design
A multicenter, prospective, observational study.
Setting
Beijing, Shandong Province, Gansu Province of China.
Participants
A total of 1, 290 OSA patients aged 60 to 96 years from sleep centers of six hospitals in China consecutively recruited between January 2015 and October 2017.
Measurements
Cox proportional models assessed the association between tHcy and the risk of new-onset all events among Chinese older OSA patients.
Results
The final analysis (60.1% male; median age, 66 years) used data from 1, 100 subjects during a median follow-up of 42 months, a total of 105 (9.5%) patients developed MACE and 42 (3.8%) patients died. Multivariable Cox regression analysis showed higher adjusted hazard ratios (aHRs) of MACE, myocardial infarction (MI), hospitalization for unstable angina, and composite of all events with tHcy levels in the 4th quartile (HR=5.93, 95% CI: 2.79–12.59; HR=4.72, 95% CI:1.36–4.61; HR=4.26, 95% CI:1.62–5.71; HR=4.17, 95% CI:2.23–7.81) and the 3rd quartile (HR=3.79, 95% CI:1.76–8.20; HR=3.65, 95% CI:1.04–2.98; HR=2.75, 95% CI:1.08–3.76; HR=2.51, 95% CI:1.31–4.83) compared to reference tHcy levels in quartile 1, respectively, while the aHRs (95% CIs) of all-cause death showed significantly higher only in the highest tHcy level quartile than in the lowest quartile (HR=3.20, 95% CI=1.16–8.84, P=0.025) with no significant differences in risks of cardiovascular death and hospitalisation for heart failure among groups (P>0.05).
Conclusions
tHcy, a marker of prognosis for older OSA patients, was significantly associated with the increased risk of MACE and all-cause death in this population independent of BMI, smoking status, and other potential risk factors, but not all clinical components events of MACE. New therapeutic approaches for older patients with OSA should mitigate tHcy-associated risks of MACE, and even all-cause death.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-022-1840-6</identifier><identifier>PMID: 36156680</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Aged ; Aging ; Biomarkers ; Cardiovascular disease ; Female ; Geriatrics/Gerontology ; Health risks ; Homocysteine ; Humans ; Male ; Medicine ; Medicine & Public Health ; Myocardial Infarction - epidemiology ; Neurosciences ; Nutrition ; Older people ; Original Research ; Primary Care Medicine ; Prospective Studies ; Quality of Life Research ; Risk Factors ; Sleep apnea ; Sleep Apnea, Obstructive - complications</subject><ispartof>The Journal of nutrition, health & aging, 2022-09, Vol.26 (9), p.879-888</ispartof><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2022</rights><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-f4c02ab9a2238c677b165924c30a11141001eb64fdd233ba45a6f9c6ba674cdd3</citedby><cites>FETCH-LOGICAL-c415t-f4c02ab9a2238c677b165924c30a11141001eb64fdd233ba45a6f9c6ba674cdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-022-1840-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-022-1840-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36156680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, L.</creatorcontrib><creatorcontrib>Su, X.</creatorcontrib><creatorcontrib>Zhao, L.</creatorcontrib><creatorcontrib>Li, J.</creatorcontrib><creatorcontrib>Xu, W.</creatorcontrib><creatorcontrib>Yang, L.</creatorcontrib><creatorcontrib>Yang, Y.</creatorcontrib><creatorcontrib>Gao, Y.</creatorcontrib><creatorcontrib>Chen, K.</creatorcontrib><creatorcontrib>Gao, Y.</creatorcontrib><creatorcontrib>Guo, J. J.</creatorcontrib><creatorcontrib>Wang, H.</creatorcontrib><creatorcontrib>Lin, J.</creatorcontrib><creatorcontrib>Han, Jiming</creatorcontrib><creatorcontrib>Fan, Li</creatorcontrib><creatorcontrib>Fang, Xiangqun</creatorcontrib><title>Association of Homocysteine and Risks of Long-Term Cardiovascular Events and All-Cause Death among Older Patients with Obstructive Sleep Apnea: A Prospective Study</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Objectives
This study aimed to assess whether raised baseline plasma tHcy concentrations increased the risks of major adverse cardiovascular events (MACE) and all-cause death outcomes in older patients with obstructive sleep apnea (OSA).
Design
A multicenter, prospective, observational study.
Setting
Beijing, Shandong Province, Gansu Province of China.
Participants
A total of 1, 290 OSA patients aged 60 to 96 years from sleep centers of six hospitals in China consecutively recruited between January 2015 and October 2017.
Measurements
Cox proportional models assessed the association between tHcy and the risk of new-onset all events among Chinese older OSA patients.
Results
The final analysis (60.1% male; median age, 66 years) used data from 1, 100 subjects during a median follow-up of 42 months, a total of 105 (9.5%) patients developed MACE and 42 (3.8%) patients died. Multivariable Cox regression analysis showed higher adjusted hazard ratios (aHRs) of MACE, myocardial infarction (MI), hospitalization for unstable angina, and composite of all events with tHcy levels in the 4th quartile (HR=5.93, 95% CI: 2.79–12.59; HR=4.72, 95% CI:1.36–4.61; HR=4.26, 95% CI:1.62–5.71; HR=4.17, 95% CI:2.23–7.81) and the 3rd quartile (HR=3.79, 95% CI:1.76–8.20; HR=3.65, 95% CI:1.04–2.98; HR=2.75, 95% CI:1.08–3.76; HR=2.51, 95% CI:1.31–4.83) compared to reference tHcy levels in quartile 1, respectively, while the aHRs (95% CIs) of all-cause death showed significantly higher only in the highest tHcy level quartile than in the lowest quartile (HR=3.20, 95% CI=1.16–8.84, P=0.025) with no significant differences in risks of cardiovascular death and hospitalisation for heart failure among groups (P>0.05).
Conclusions
tHcy, a marker of prognosis for older OSA patients, was significantly associated with the increased risk of MACE and all-cause death in this population independent of BMI, smoking status, and other potential risk factors, but not all clinical components events of MACE. New therapeutic approaches for older patients with OSA should mitigate tHcy-associated risks of MACE, and even all-cause death.</description><subject>Aged</subject><subject>Aging</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Female</subject><subject>Geriatrics/Gerontology</subject><subject>Health risks</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Older people</subject><subject>Original Research</subject><subject>Primary Care Medicine</subject><subject>Prospective Studies</subject><subject>Quality of Life Research</subject><subject>Risk Factors</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - complications</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kcFu1DAURSNERUvhA9ggS2zYuLUdx07YRUOhlUaaCso6cpyX4pLYwS8ZNN_Dj-LpDCAhsbKle-599rtZ9oqzC86YvkQuFMspE4LyUjKqnmRnXCtGpS7Lp-kudEW1Zvo0e474wJgsqlI9y05zxQulSnaW_awRg3VmdsGT0JPrMAa7wxmcB2J8Rz45_IZ7ZR38Pb2DOJKViZ0LW4N2GUwkV1vwMz7C9TDQlVkQyHsw81dixmQim6GDSG7TjEfwh0vKpsU5LnZ2WyCfB4CJ1JMH847U5DYGnOAozUu3e5Gd9GZAeHk8z7MvH67uVtd0vfl4s6rX1EpezLSXlgnTVkaIvLRK65arohLS5sxwzmVaGYdWyb7rRJ63RhZG9ZVVrVFa2q7Lz7O3h9wphu8L4NyMDi0Mg_EQFmyE5qXKKy5FQt_8gz6EJfr0uj2lc5VWXSSKHyibvoQR-maKbjRx13DW7BtsDg02qcFm32Cjkuf1MXlpR-j-OH5XlgBxADBJ_h7i39H_T_0FKWanQA</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Liu, L.</creator><creator>Su, X.</creator><creator>Zhao, L.</creator><creator>Li, J.</creator><creator>Xu, W.</creator><creator>Yang, L.</creator><creator>Yang, Y.</creator><creator>Gao, Y.</creator><creator>Chen, K.</creator><creator>Gao, Y.</creator><creator>Guo, J. J.</creator><creator>Wang, H.</creator><creator>Lin, J.</creator><creator>Han, Jiming</creator><creator>Fan, Li</creator><creator>Fang, Xiangqun</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20220901</creationdate><title>Association of Homocysteine and Risks of Long-Term Cardiovascular Events and All-Cause Death among Older Patients with Obstructive Sleep Apnea: A Prospective Study</title><author>Liu, L. ; Su, X. ; Zhao, L. ; Li, J. ; Xu, W. ; Yang, L. ; Yang, Y. ; Gao, Y. ; Chen, K. ; Gao, Y. ; Guo, J. J. ; Wang, H. ; Lin, J. ; Han, Jiming ; Fan, Li ; Fang, Xiangqun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-f4c02ab9a2238c677b165924c30a11141001eb64fdd233ba45a6f9c6ba674cdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Female</topic><topic>Geriatrics/Gerontology</topic><topic>Health risks</topic><topic>Homocysteine</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Older people</topic><topic>Original Research</topic><topic>Primary Care Medicine</topic><topic>Prospective Studies</topic><topic>Quality of Life Research</topic><topic>Risk Factors</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, L.</creatorcontrib><creatorcontrib>Su, X.</creatorcontrib><creatorcontrib>Zhao, L.</creatorcontrib><creatorcontrib>Li, J.</creatorcontrib><creatorcontrib>Xu, W.</creatorcontrib><creatorcontrib>Yang, L.</creatorcontrib><creatorcontrib>Yang, Y.</creatorcontrib><creatorcontrib>Gao, Y.</creatorcontrib><creatorcontrib>Chen, K.</creatorcontrib><creatorcontrib>Gao, Y.</creatorcontrib><creatorcontrib>Guo, J. J.</creatorcontrib><creatorcontrib>Wang, H.</creatorcontrib><creatorcontrib>Lin, J.</creatorcontrib><creatorcontrib>Han, Jiming</creatorcontrib><creatorcontrib>Fan, Li</creatorcontrib><creatorcontrib>Fang, Xiangqun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, L.</au><au>Su, X.</au><au>Zhao, L.</au><au>Li, J.</au><au>Xu, W.</au><au>Yang, L.</au><au>Yang, Y.</au><au>Gao, Y.</au><au>Chen, K.</au><au>Gao, Y.</au><au>Guo, J. J.</au><au>Wang, H.</au><au>Lin, J.</au><au>Han, Jiming</au><au>Fan, Li</au><au>Fang, Xiangqun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Homocysteine and Risks of Long-Term Cardiovascular Events and All-Cause Death among Older Patients with Obstructive Sleep Apnea: A Prospective Study</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>26</volume><issue>9</issue><spage>879</spage><epage>888</epage><pages>879-888</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Objectives
This study aimed to assess whether raised baseline plasma tHcy concentrations increased the risks of major adverse cardiovascular events (MACE) and all-cause death outcomes in older patients with obstructive sleep apnea (OSA).
Design
A multicenter, prospective, observational study.
Setting
Beijing, Shandong Province, Gansu Province of China.
Participants
A total of 1, 290 OSA patients aged 60 to 96 years from sleep centers of six hospitals in China consecutively recruited between January 2015 and October 2017.
Measurements
Cox proportional models assessed the association between tHcy and the risk of new-onset all events among Chinese older OSA patients.
Results
The final analysis (60.1% male; median age, 66 years) used data from 1, 100 subjects during a median follow-up of 42 months, a total of 105 (9.5%) patients developed MACE and 42 (3.8%) patients died. Multivariable Cox regression analysis showed higher adjusted hazard ratios (aHRs) of MACE, myocardial infarction (MI), hospitalization for unstable angina, and composite of all events with tHcy levels in the 4th quartile (HR=5.93, 95% CI: 2.79–12.59; HR=4.72, 95% CI:1.36–4.61; HR=4.26, 95% CI:1.62–5.71; HR=4.17, 95% CI:2.23–7.81) and the 3rd quartile (HR=3.79, 95% CI:1.76–8.20; HR=3.65, 95% CI:1.04–2.98; HR=2.75, 95% CI:1.08–3.76; HR=2.51, 95% CI:1.31–4.83) compared to reference tHcy levels in quartile 1, respectively, while the aHRs (95% CIs) of all-cause death showed significantly higher only in the highest tHcy level quartile than in the lowest quartile (HR=3.20, 95% CI=1.16–8.84, P=0.025) with no significant differences in risks of cardiovascular death and hospitalisation for heart failure among groups (P>0.05).
Conclusions
tHcy, a marker of prognosis for older OSA patients, was significantly associated with the increased risk of MACE and all-cause death in this population independent of BMI, smoking status, and other potential risk factors, but not all clinical components events of MACE. New therapeutic approaches for older patients with OSA should mitigate tHcy-associated risks of MACE, and even all-cause death.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>36156680</pmid><doi>10.1007/s12603-022-1840-6</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2022-09, Vol.26 (9), p.879-888 |
| issn | 1279-7707 1760-4788 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2718639142 |
| source | MEDLINE; SpringerNature Journals; Alma/SFX Local Collection |
| subjects | Aged Aging Biomarkers Cardiovascular disease Female Geriatrics/Gerontology Health risks Homocysteine Humans Male Medicine Medicine & Public Health Myocardial Infarction - epidemiology Neurosciences Nutrition Older people Original Research Primary Care Medicine Prospective Studies Quality of Life Research Risk Factors Sleep apnea Sleep Apnea, Obstructive - complications |
| title | Association of Homocysteine and Risks of Long-Term Cardiovascular Events and All-Cause Death among Older Patients with Obstructive Sleep Apnea: A Prospective Study |
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