Pathological effects of graded doses of aflatoxin B1 on the development of the testes in juvenile white leghorn males
Current experiment was planned to investigate the deleterious effects of the graded doses of aflatoxin B1 (AFB1) on white leghorn male birds. For this purpose, one-hundred birds of 8 weeks of age were divided into 4 equal groups and reared on feed contaminated with different doses of AFB1 for 10 wee...
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| creator | Ashraf, Anas Saleemi, Muhammad Kashif Mohsin, Mashkoor Gul, Shafia Tehseen Zubair, Muhammad Muhammad, Faqir Bhatti, Sheraz Ahmed Hameed, Muhammad Raza Imran, Muhammad Irshad, Hamid Zaheer, Iqra Ahmed, Ishtiaq Raza, Ahmad Qureshi, Anas Sarwar Khan, Ahrar |
| description | Current experiment was planned to investigate the deleterious effects of the graded doses of aflatoxin B1 (AFB1) on white leghorn male birds. For this purpose, one-hundred birds of 8 weeks of age were divided into 4 equal groups and reared on feed contaminated with different doses of AFB1 for 10 weeks. Group A was kept as a control group and was fed with normal toxin-free diet; groups B, C, and D were offered feed containing 100 ppb, 200 ppb, and 400 ppb of AFB1, respectively. The birds were euthanized at the 4th and 10th week of the experiment. Clinical signs, behavioral changes, absolute and relative organ weight of the testes, and sperm motility were measured. Cellular immune response was observed through carbon clearance assay (CCA), P-HAP, and antibody response against sheep red blood cells (SRBC). Results showed a dose-dependent decline in the immune response of birds with the increase in the level of AFB1 in the feed. A significant decrease in the serum levels of testosterone, prolactin, and LH were observed at the end of the study. Grossly, testicular size and volume were reduced in ABF1 fed birds, while histological examination showed moderate to severe necrosis of testicular parenchyma, with partial to complete arrest of spermatogenesis. Very few spermatozoa were found in group C, while they were almost absent in group D which was offered a diet containing 400 ppb AFB1. The motility of sperms was reduced in all treated groups except control. The abovementioned results showed that AFB1 had severe toxic effects on the reproductive and immunological parameters of WLH male birds in a dose-dependent manner. |
| doi_str_mv | 10.1007/s11356-022-19324-6 |
| format | Article |
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For this purpose, one-hundred birds of 8 weeks of age were divided into 4 equal groups and reared on feed contaminated with different doses of AFB1 for 10 weeks. Group A was kept as a control group and was fed with normal toxin-free diet; groups B, C, and D were offered feed containing 100 ppb, 200 ppb, and 400 ppb of AFB1, respectively. The birds were euthanized at the 4th and 10th week of the experiment. Clinical signs, behavioral changes, absolute and relative organ weight of the testes, and sperm motility were measured. Cellular immune response was observed through carbon clearance assay (CCA), P-HAP, and antibody response against sheep red blood cells (SRBC). Results showed a dose-dependent decline in the immune response of birds with the increase in the level of AFB1 in the feed. A significant decrease in the serum levels of testosterone, prolactin, and LH were observed at the end of the study. Grossly, testicular size and volume were reduced in ABF1 fed birds, while histological examination showed moderate to severe necrosis of testicular parenchyma, with partial to complete arrest of spermatogenesis. Very few spermatozoa were found in group C, while they were almost absent in group D which was offered a diet containing 400 ppb AFB1. The motility of sperms was reduced in all treated groups except control. The abovementioned results showed that AFB1 had severe toxic effects on the reproductive and immunological parameters of WLH male birds in a dose-dependent manner.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-022-19324-6</identifier><identifier>PMID: 35278182</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aflatoxin B1 ; Aflatoxins ; Antibodies ; antibody formation ; Antibody response ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Birds ; blood serum ; carbon ; cell-mediated immunity ; decline ; Diet ; dose response ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Erythrocytes ; histology ; Immune clearance ; Immune response ; Immune response (cell-mediated) ; Immune system ; Immunology ; juveniles ; Males ; Motility ; Necrosis ; Organ weight ; Parenchyma ; Pathological effects ; Prolactin ; Research Article ; Serum levels ; sheep ; Sheep red blood cells ; sperm motility ; Spermatogenesis ; Spermatozoa ; Testes ; Testosterone ; tissue weight ; toxicity ; Toxins ; Waste Water Technology ; Water Management ; Water Pollution Control ; White Leghorn</subject><ispartof>Environmental science and pollution research international, 2022-07, Vol.29 (35), p.53158-53167</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-3728067ddeeb1729d49957495ba2cbc12c6802b215bfd297c44fa6feec9ab5ea3</citedby><cites>FETCH-LOGICAL-c452t-3728067ddeeb1729d49957495ba2cbc12c6802b215bfd297c44fa6feec9ab5ea3</cites><orcidid>0000-0003-2980-9543</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-022-19324-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-022-19324-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35278182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashraf, Anas</creatorcontrib><creatorcontrib>Saleemi, Muhammad Kashif</creatorcontrib><creatorcontrib>Mohsin, Mashkoor</creatorcontrib><creatorcontrib>Gul, Shafia Tehseen</creatorcontrib><creatorcontrib>Zubair, Muhammad</creatorcontrib><creatorcontrib>Muhammad, Faqir</creatorcontrib><creatorcontrib>Bhatti, Sheraz Ahmed</creatorcontrib><creatorcontrib>Hameed, Muhammad Raza</creatorcontrib><creatorcontrib>Imran, Muhammad</creatorcontrib><creatorcontrib>Irshad, Hamid</creatorcontrib><creatorcontrib>Zaheer, Iqra</creatorcontrib><creatorcontrib>Ahmed, Ishtiaq</creatorcontrib><creatorcontrib>Raza, Ahmad</creatorcontrib><creatorcontrib>Qureshi, Anas Sarwar</creatorcontrib><creatorcontrib>Khan, Ahrar</creatorcontrib><title>Pathological effects of graded doses of aflatoxin B1 on the development of the testes in juvenile white leghorn males</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Current experiment was planned to investigate the deleterious effects of the graded doses of aflatoxin B1 (AFB1) on white leghorn male birds. For this purpose, one-hundred birds of 8 weeks of age were divided into 4 equal groups and reared on feed contaminated with different doses of AFB1 for 10 weeks. Group A was kept as a control group and was fed with normal toxin-free diet; groups B, C, and D were offered feed containing 100 ppb, 200 ppb, and 400 ppb of AFB1, respectively. The birds were euthanized at the 4th and 10th week of the experiment. Clinical signs, behavioral changes, absolute and relative organ weight of the testes, and sperm motility were measured. Cellular immune response was observed through carbon clearance assay (CCA), P-HAP, and antibody response against sheep red blood cells (SRBC). Results showed a dose-dependent decline in the immune response of birds with the increase in the level of AFB1 in the feed. A significant decrease in the serum levels of testosterone, prolactin, and LH were observed at the end of the study. Grossly, testicular size and volume were reduced in ABF1 fed birds, while histological examination showed moderate to severe necrosis of testicular parenchyma, with partial to complete arrest of spermatogenesis. Very few spermatozoa were found in group C, while they were almost absent in group D which was offered a diet containing 400 ppb AFB1. The motility of sperms was reduced in all treated groups except control. The abovementioned results showed that AFB1 had severe toxic effects on the reproductive and immunological parameters of WLH male birds in a dose-dependent manner.</description><subject>Aflatoxin B1</subject><subject>Aflatoxins</subject><subject>Antibodies</subject><subject>antibody formation</subject><subject>Antibody response</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Birds</subject><subject>blood serum</subject><subject>carbon</subject><subject>cell-mediated immunity</subject><subject>decline</subject><subject>Diet</subject><subject>dose response</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Erythrocytes</subject><subject>histology</subject><subject>Immune clearance</subject><subject>Immune response</subject><subject>Immune response (cell-mediated)</subject><subject>Immune system</subject><subject>Immunology</subject><subject>juveniles</subject><subject>Males</subject><subject>Motility</subject><subject>Necrosis</subject><subject>Organ weight</subject><subject>Parenchyma</subject><subject>Pathological effects</subject><subject>Prolactin</subject><subject>Research Article</subject><subject>Serum levels</subject><subject>sheep</subject><subject>Sheep red blood cells</subject><subject>sperm motility</subject><subject>Spermatogenesis</subject><subject>Spermatozoa</subject><subject>Testes</subject><subject>Testosterone</subject><subject>tissue weight</subject><subject>toxicity</subject><subject>Toxins</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>White 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effects of graded doses of aflatoxin B1 on the development of the testes in juvenile white leghorn males</title><author>Ashraf, Anas ; Saleemi, Muhammad Kashif ; Mohsin, Mashkoor ; Gul, Shafia Tehseen ; Zubair, Muhammad ; Muhammad, Faqir ; Bhatti, Sheraz Ahmed ; Hameed, Muhammad Raza ; Imran, Muhammad ; Irshad, Hamid ; Zaheer, Iqra ; Ahmed, Ishtiaq ; Raza, Ahmad ; Qureshi, Anas Sarwar ; Khan, Ahrar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-3728067ddeeb1729d49957495ba2cbc12c6802b215bfd297c44fa6feec9ab5ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aflatoxin B1</topic><topic>Aflatoxins</topic><topic>Antibodies</topic><topic>antibody formation</topic><topic>Antibody response</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Birds</topic><topic>blood 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For this purpose, one-hundred birds of 8 weeks of age were divided into 4 equal groups and reared on feed contaminated with different doses of AFB1 for 10 weeks. Group A was kept as a control group and was fed with normal toxin-free diet; groups B, C, and D were offered feed containing 100 ppb, 200 ppb, and 400 ppb of AFB1, respectively. The birds were euthanized at the 4th and 10th week of the experiment. Clinical signs, behavioral changes, absolute and relative organ weight of the testes, and sperm motility were measured. Cellular immune response was observed through carbon clearance assay (CCA), P-HAP, and antibody response against sheep red blood cells (SRBC). Results showed a dose-dependent decline in the immune response of birds with the increase in the level of AFB1 in the feed. A significant decrease in the serum levels of testosterone, prolactin, and LH were observed at the end of the study. Grossly, testicular size and volume were reduced in ABF1 fed birds, while histological examination showed moderate to severe necrosis of testicular parenchyma, with partial to complete arrest of spermatogenesis. Very few spermatozoa were found in group C, while they were almost absent in group D which was offered a diet containing 400 ppb AFB1. The motility of sperms was reduced in all treated groups except control. The abovementioned results showed that AFB1 had severe toxic effects on the reproductive and immunological parameters of WLH male birds in a dose-dependent manner.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35278182</pmid><doi>10.1007/s11356-022-19324-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2980-9543</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2022-07, Vol.29 (35), p.53158-53167 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2718355497 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Aflatoxin B1 Aflatoxins Antibodies antibody formation Antibody response Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Birds blood serum carbon cell-mediated immunity decline Diet dose response Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Erythrocytes histology Immune clearance Immune response Immune response (cell-mediated) Immune system Immunology juveniles Males Motility Necrosis Organ weight Parenchyma Pathological effects Prolactin Research Article Serum levels sheep Sheep red blood cells sperm motility Spermatogenesis Spermatozoa Testes Testosterone tissue weight toxicity Toxins Waste Water Technology Water Management Water Pollution Control White Leghorn |
| title | Pathological effects of graded doses of aflatoxin B1 on the development of the testes in juvenile white leghorn males |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T23%3A26%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pathological%20effects%20of%20graded%20doses%20of%20aflatoxin%20B1%20on%20the%20development%20of%20the%20testes%20in%20juvenile%20white%20leghorn%20males&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Ashraf,%20Anas&rft.date=2022-07-01&rft.volume=29&rft.issue=35&rft.spage=53158&rft.epage=53167&rft.pages=53158-53167&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-022-19324-6&rft_dat=%3Cproquest_cross%3E2718355497%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2696970889&rft_id=info:pmid/35278182&rfr_iscdi=true |