Communities of niche-optimized strains (CoNoS) – Design and creation of stable, genome-reduced co-cultures

Current bioprocesses for production of value-added compounds are mainly based on pure cultures that are composed of rationally engineered strains of model organisms with versatile metabolic capacities. However, in the comparably well-defined environment of a bioreactor, metabolic flexibility provide...

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Veröffentlicht in:	Metabolic engineering 2022-09, Vol.73, p.91-103
Hauptverfasser:	Schito, Simone, Zuchowski, Rico, Bergen, Daniel, Strohmeier, Daniel, Wollenhaupt, Bastian, Menke, Philipp, Seiffarth, Johannes, Nöh, Katharina, Kohlheyer, Dietrich, Bott, Michael, Wiechert, Wolfgang, Baumgart, Meike, Noack, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	arginine auxotrophs bioreactors biosynthesis C. glutamicum carbon coculture Corynebacterium glutamicum energy Genome reduction leucine Microbial communities specific growth rate Synthetic cocultures value added
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