The INSR/AKT/mTOR pathway regulates the pace of myogenesis in a syndecan-3-dependent manner

•A phosphoproteomic survey of muscle stem cell progeny reveals that syndecans-3 regulates tyrosine kinase receptor-mediated signal transduction at multiple levels, including insulin/INSR signaling as one of the most enriched pathways.•The presence of syndecan-3 in muscle stem cells during the early...

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Veröffentlicht in:	Matrix biology 2022-11, Vol.113, p.61-82
Hauptverfasser:	Jones, Fiona K., Phillips, Alexander M., Jones, Andrew R., Pisconti, Addolorata
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT AKT protein Cell Differentiation Cells, Cultured Differentiation Insulin Insulin receptor Insulin signaling mTOR Muscle Development - genetics Muscle stem cells Muscle, Skeletal - metabolism Myocytes Myogenesis Phosphoproteomics Progenitor cells Proliferation Proteoglycan Proteomics Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Satellite cells Signal transduction Stem cells Syndecan Syndecan-3 Syndecan-3 - genetics Syndecan-3 - metabolism Syndecans TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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