Ameliorative effect of the probiotic peptide against benzo(α)pyrene-induced inflammatory damages in enterocytes
LRCP-1 [Cycle-(Thr-His-Ala-Trp)] effectively inhibited BaP- induced pro-inflammatory cytokines release and ROS overproduction by inhibiting NOXs, MMPs expressions and regulating the AhR/Nrf2 pathways. [Display omitted] Probiotics are living bacteria that provide health benefits to the host when cons...
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| Veröffentlicht in: | International immunopharmacology 2022-11, Vol.112, p.109255-109255, Article 109255 |
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| container_title | International immunopharmacology |
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| creator | Luo, Min Luo, Dan Liu, Jie Wang, Huailing Liu, Xiaoyu Yang, Min Tian, Fangfang Qin, Suofu Li, Yuying |
| description | LRCP-1 [Cycle-(Thr-His-Ala-Trp)] effectively inhibited BaP- induced pro-inflammatory cytokines release and ROS overproduction by inhibiting NOXs, MMPs expressions and regulating the AhR/Nrf2 pathways.
[Display omitted]
Probiotics are living bacteria that provide health benefits to the host when consumed in sufficient quantities. However, the protective effect of the bioactive peptides isolated from the probiotics against benzo(α)pyrene (BaP) induced gastrointestinal injury has never been investigated. The current work used a bio-assay guided technique to identify-four new cyclic peptides in BaP-induced Caco-2 cell culture and mouse colitis model. Lactobacillus rhamnosus cycle (Thr-His-Ala-Trp) peptide-1 (LRCP-1) effectively inhibited BaP-induced epithelial cytokine over-release and intracellular ROS over-production. Simultaneously, LRCP-1 attenuated BaP-induced NAD (P)H: oxidases (NOXs), Matrix metalloproteinases (MMPs) over-expression, respectively. Furthermore, increased NAD (P)H: quinone oxidoreductase 1 (NQO1)/heme oxygenase-1 (HO-1)/nuclear factor E2-related factor 2 (Nrf2) expression and aryl hydrocarbon receptor (AhR) pathway activation induced by the BaP-exposure were also inhibited after the LRCP-1 treatment. Notably, LRCP-1 is a promising agent protecting gastrointestinal epithelial cells from BaP-induced inflammatory and oxidative damages. |
| doi_str_mv | 10.1016/j.intimp.2022.109255 |
| format | Article |
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[Display omitted]
Probiotics are living bacteria that provide health benefits to the host when consumed in sufficient quantities. However, the protective effect of the bioactive peptides isolated from the probiotics against benzo(α)pyrene (BaP) induced gastrointestinal injury has never been investigated. The current work used a bio-assay guided technique to identify-four new cyclic peptides in BaP-induced Caco-2 cell culture and mouse colitis model. Lactobacillus rhamnosus cycle (Thr-His-Ala-Trp) peptide-1 (LRCP-1) effectively inhibited BaP-induced epithelial cytokine over-release and intracellular ROS over-production. Simultaneously, LRCP-1 attenuated BaP-induced NAD (P)H: oxidases (NOXs), Matrix metalloproteinases (MMPs) over-expression, respectively. Furthermore, increased NAD (P)H: quinone oxidoreductase 1 (NQO1)/heme oxygenase-1 (HO-1)/nuclear factor E2-related factor 2 (Nrf2) expression and aryl hydrocarbon receptor (AhR) pathway activation induced by the BaP-exposure were also inhibited after the LRCP-1 treatment. Notably, LRCP-1 is a promising agent protecting gastrointestinal epithelial cells from BaP-induced inflammatory and oxidative damages.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2022.109255</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>AhR ; Benzo(α)pyrene ; Cyclic peptide ; Lactobacillus Rhamnosus</subject><ispartof>International immunopharmacology, 2022-11, Vol.112, p.109255-109255, Article 109255</ispartof><rights>2022 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-9cb0437f531918e311f51fe011e92d166eea2e0bdd2f357753a0444bfd69cb353</citedby><cites>FETCH-LOGICAL-c385t-9cb0437f531918e311f51fe011e92d166eea2e0bdd2f357753a0444bfd69cb353</cites><orcidid>0000-0003-0507-1687 ; 0000-0002-3054-5568</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1567576922007391$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Luo, Min</creatorcontrib><creatorcontrib>Luo, Dan</creatorcontrib><creatorcontrib>Liu, Jie</creatorcontrib><creatorcontrib>Wang, Huailing</creatorcontrib><creatorcontrib>Liu, Xiaoyu</creatorcontrib><creatorcontrib>Yang, Min</creatorcontrib><creatorcontrib>Tian, Fangfang</creatorcontrib><creatorcontrib>Qin, Suofu</creatorcontrib><creatorcontrib>Li, Yuying</creatorcontrib><title>Ameliorative effect of the probiotic peptide against benzo(α)pyrene-induced inflammatory damages in enterocytes</title><title>International immunopharmacology</title><description>LRCP-1 [Cycle-(Thr-His-Ala-Trp)] effectively inhibited BaP- induced pro-inflammatory cytokines release and ROS overproduction by inhibiting NOXs, MMPs expressions and regulating the AhR/Nrf2 pathways.
[Display omitted]
Probiotics are living bacteria that provide health benefits to the host when consumed in sufficient quantities. However, the protective effect of the bioactive peptides isolated from the probiotics against benzo(α)pyrene (BaP) induced gastrointestinal injury has never been investigated. The current work used a bio-assay guided technique to identify-four new cyclic peptides in BaP-induced Caco-2 cell culture and mouse colitis model. Lactobacillus rhamnosus cycle (Thr-His-Ala-Trp) peptide-1 (LRCP-1) effectively inhibited BaP-induced epithelial cytokine over-release and intracellular ROS over-production. Simultaneously, LRCP-1 attenuated BaP-induced NAD (P)H: oxidases (NOXs), Matrix metalloproteinases (MMPs) over-expression, respectively. Furthermore, increased NAD (P)H: quinone oxidoreductase 1 (NQO1)/heme oxygenase-1 (HO-1)/nuclear factor E2-related factor 2 (Nrf2) expression and aryl hydrocarbon receptor (AhR) pathway activation induced by the BaP-exposure were also inhibited after the LRCP-1 treatment. Notably, LRCP-1 is a promising agent protecting gastrointestinal epithelial cells from BaP-induced inflammatory and oxidative damages.</description><subject>AhR</subject><subject>Benzo(α)pyrene</subject><subject>Cyclic peptide</subject><subject>Lactobacillus Rhamnosus</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEYhYMoWC9v4CLLupiazEzmshFK8QYFN7oOmeRPTZlJxiQt1LfyRXwmU8a1q__ncM6B8yF0Q8mCElrdbRfGRjOMi5zkeZLanLETNKNN3WS0Juw0_ayqM1ZX7Tm6CGFLSNJLOkPjcoDeOC-i2QMGrUFG7DSOH4BH7zrjopF4hDEaBVhshLEh4g7sl5v_fN-OBw8WMmPVToLCxupeDIOIzh-wEoPYQEgiBhvBO3mIEK7QmRZ9gOu_e4neHx_eVs_Z-vXpZbVcZ7JoWMxa2ZGyqDUraEsbKCjVjGoglEKbK1pVACIH0imV64LVNSsEKcuy06pK0YIVl2g-9aYVnzsIkQ8mSOh7YcHtAs9rmmg0ZUuStZys0rsQPGg-ejMIf-CU8CNgvuUTYH4EzCfAKXY_xSDN2BvwPEgDNnEwPlHkypn_C34BbJmJBA</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Luo, Min</creator><creator>Luo, Dan</creator><creator>Liu, Jie</creator><creator>Wang, Huailing</creator><creator>Liu, Xiaoyu</creator><creator>Yang, Min</creator><creator>Tian, Fangfang</creator><creator>Qin, Suofu</creator><creator>Li, Yuying</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0507-1687</orcidid><orcidid>https://orcid.org/0000-0002-3054-5568</orcidid></search><sort><creationdate>202211</creationdate><title>Ameliorative effect of the probiotic peptide against benzo(α)pyrene-induced inflammatory damages in enterocytes</title><author>Luo, Min ; Luo, Dan ; Liu, Jie ; Wang, Huailing ; Liu, Xiaoyu ; Yang, Min ; Tian, Fangfang ; Qin, Suofu ; Li, Yuying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-9cb0437f531918e311f51fe011e92d166eea2e0bdd2f357753a0444bfd69cb353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>AhR</topic><topic>Benzo(α)pyrene</topic><topic>Cyclic peptide</topic><topic>Lactobacillus Rhamnosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Min</creatorcontrib><creatorcontrib>Luo, Dan</creatorcontrib><creatorcontrib>Liu, Jie</creatorcontrib><creatorcontrib>Wang, Huailing</creatorcontrib><creatorcontrib>Liu, Xiaoyu</creatorcontrib><creatorcontrib>Yang, Min</creatorcontrib><creatorcontrib>Tian, Fangfang</creatorcontrib><creatorcontrib>Qin, Suofu</creatorcontrib><creatorcontrib>Li, Yuying</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Min</au><au>Luo, Dan</au><au>Liu, Jie</au><au>Wang, Huailing</au><au>Liu, Xiaoyu</au><au>Yang, Min</au><au>Tian, Fangfang</au><au>Qin, Suofu</au><au>Li, Yuying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ameliorative effect of the probiotic peptide against benzo(α)pyrene-induced inflammatory damages in enterocytes</atitle><jtitle>International immunopharmacology</jtitle><date>2022-11</date><risdate>2022</risdate><volume>112</volume><spage>109255</spage><epage>109255</epage><pages>109255-109255</pages><artnum>109255</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>LRCP-1 [Cycle-(Thr-His-Ala-Trp)] effectively inhibited BaP- induced pro-inflammatory cytokines release and ROS overproduction by inhibiting NOXs, MMPs expressions and regulating the AhR/Nrf2 pathways.
[Display omitted]
Probiotics are living bacteria that provide health benefits to the host when consumed in sufficient quantities. However, the protective effect of the bioactive peptides isolated from the probiotics against benzo(α)pyrene (BaP) induced gastrointestinal injury has never been investigated. The current work used a bio-assay guided technique to identify-four new cyclic peptides in BaP-induced Caco-2 cell culture and mouse colitis model. Lactobacillus rhamnosus cycle (Thr-His-Ala-Trp) peptide-1 (LRCP-1) effectively inhibited BaP-induced epithelial cytokine over-release and intracellular ROS over-production. Simultaneously, LRCP-1 attenuated BaP-induced NAD (P)H: oxidases (NOXs), Matrix metalloproteinases (MMPs) over-expression, respectively. Furthermore, increased NAD (P)H: quinone oxidoreductase 1 (NQO1)/heme oxygenase-1 (HO-1)/nuclear factor E2-related factor 2 (Nrf2) expression and aryl hydrocarbon receptor (AhR) pathway activation induced by the BaP-exposure were also inhibited after the LRCP-1 treatment. Notably, LRCP-1 is a promising agent protecting gastrointestinal epithelial cells from BaP-induced inflammatory and oxidative damages.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.intimp.2022.109255</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0507-1687</orcidid><orcidid>https://orcid.org/0000-0002-3054-5568</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | AhR Benzo(α)pyrene Cyclic peptide Lactobacillus Rhamnosus |
| title | Ameliorative effect of the probiotic peptide against benzo(α)pyrene-induced inflammatory damages in enterocytes |
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