Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening
Objective The aim of this study was to evaluate the features of asymptomatic siblings of index celiac patients who were diagnosed with celiac disease (CD) at the initial screening. Methods We reviewed hospital records of 210 children with CD. The characteristics of sibling celiacs ( n =24) were comp...
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| Veröffentlicht in: | Indian pediatrics 2022-11, Vol.59 (11), p.867-870 |
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| container_title | Indian pediatrics |
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| creator | Akkelle, Bilge S. Volkan, Burcu Tutar, Engin Ertem, Deniz |
| description | Objective
The aim of this study was to evaluate the features of asymptomatic siblings of index celiac patients who were diagnosed with celiac disease (CD) at the initial screening.
Methods
We reviewed hospital records of 210 children with CD. The characteristics of sibling celiacs (
n
=24) were compared with index celiacs (
n
=186).
Results
At diagnosis, sibling celiacs were older than index celiacs (mean (SD) 10.4 (2.7) vs 8.2 (4.3) years; P=0.02). There were no significant differences between sibling and index celiacs in terms of serum anti-tTG IgA titer (≥10xULN, 83.3% vs 85%), and most of the patients had moderate/severe villous atrophy in both groups. The rates of iron deficiency anemia, folic acid deficiency, wasting and stunting were comparable between sibling and index celiac patients.
Conclusions
Siblings with CD were older than index children with CD at diagnosis, and their characteristics were similar to symptomatic index children with CD, despite not having any complaints. |
| doi_str_mv | 10.1007/s13312-022-2645-8 |
| format | Article |
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The aim of this study was to evaluate the features of asymptomatic siblings of index celiac patients who were diagnosed with celiac disease (CD) at the initial screening.
Methods
We reviewed hospital records of 210 children with CD. The characteristics of sibling celiacs (
n
=24) were compared with index celiacs (
n
=186).
Results
At diagnosis, sibling celiacs were older than index celiacs (mean (SD) 10.4 (2.7) vs 8.2 (4.3) years; P=0.02). There were no significant differences between sibling and index celiacs in terms of serum anti-tTG IgA titer (≥10xULN, 83.3% vs 85%), and most of the patients had moderate/severe villous atrophy in both groups. The rates of iron deficiency anemia, folic acid deficiency, wasting and stunting were comparable between sibling and index celiac patients.
Conclusions
Siblings with CD were older than index children with CD at diagnosis, and their characteristics were similar to symptomatic index children with CD, despite not having any complaints.</description><identifier>ISSN: 0019-6061</identifier><identifier>EISSN: 0974-7559</identifier><identifier>DOI: 10.1007/s13312-022-2645-8</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Maternal and Child Health ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Research Paper</subject><ispartof>Indian pediatrics, 2022-11, Vol.59 (11), p.867-870</ispartof><rights>Indian Academy of Pediatrics 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c251t-1f9413397d34a9855d9a24ca30b7ccee2c63f77665c0153c1028662bffa7312c3</citedby><cites>FETCH-LOGICAL-c251t-1f9413397d34a9855d9a24ca30b7ccee2c63f77665c0153c1028662bffa7312c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13312-022-2645-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13312-022-2645-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids></links><search><creatorcontrib>Akkelle, Bilge S.</creatorcontrib><creatorcontrib>Volkan, Burcu</creatorcontrib><creatorcontrib>Tutar, Engin</creatorcontrib><creatorcontrib>Ertem, Deniz</creatorcontrib><title>Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><description>Objective
The aim of this study was to evaluate the features of asymptomatic siblings of index celiac patients who were diagnosed with celiac disease (CD) at the initial screening.
Methods
We reviewed hospital records of 210 children with CD. The characteristics of sibling celiacs (
n
=24) were compared with index celiacs (
n
=186).
Results
At diagnosis, sibling celiacs were older than index celiacs (mean (SD) 10.4 (2.7) vs 8.2 (4.3) years; P=0.02). There were no significant differences between sibling and index celiacs in terms of serum anti-tTG IgA titer (≥10xULN, 83.3% vs 85%), and most of the patients had moderate/severe villous atrophy in both groups. The rates of iron deficiency anemia, folic acid deficiency, wasting and stunting were comparable between sibling and index celiac patients.
Conclusions
Siblings with CD were older than index children with CD at diagnosis, and their characteristics were similar to symptomatic index children with CD, despite not having any complaints.</description><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Research Paper</subject><issn>0019-6061</issn><issn>0974-7559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kD9PwzAQxS0EEqXwAdg8shj8J7bjEQUKSEUMBTFajuu0rtKk-JKh3x5XYWa6G97v3r2H0C2j94xS_QBMCMYJ5ZxwVUhSnqEZNbogWkpznnfKDFFUsUt0BbCjlAsu2Qy9V1uXnB9CijBED7hv8CrWbew2gL_jsMVVaKPz-ClCcBDydJuuh7DG9REv3D62R7zyKYQuI9foonEthJu_OUdfi-fP6pUsP17eqscl8dl0IKwxRf7X6LUonCmlXBvHC-8ErbX3IXCvRKO1UtJTJoVnlJdK8bppnM4pvZiju-nuIfU_Y4DB7iP40LauC_0IlmumlVEnkzlik9SnHiCFxh5S3Lt0tIzaU3V2qs7m6uypOltmhk8MZG23Ccnu-jF1OdE_0C-2nHAM</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Akkelle, Bilge S.</creator><creator>Volkan, Burcu</creator><creator>Tutar, Engin</creator><creator>Ertem, Deniz</creator><general>Springer India</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20221101</creationdate><title>Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening</title><author>Akkelle, Bilge S. ; Volkan, Burcu ; Tutar, Engin ; Ertem, Deniz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c251t-1f9413397d34a9855d9a24ca30b7ccee2c63f77665c0153c1028662bffa7312c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Maternal and Child Health</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akkelle, Bilge S.</creatorcontrib><creatorcontrib>Volkan, Burcu</creatorcontrib><creatorcontrib>Tutar, Engin</creatorcontrib><creatorcontrib>Ertem, Deniz</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akkelle, Bilge S.</au><au>Volkan, Burcu</au><au>Tutar, Engin</au><au>Ertem, Deniz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening</atitle><jtitle>Indian pediatrics</jtitle><stitle>Indian Pediatr</stitle><date>2022-11-01</date><risdate>2022</risdate><volume>59</volume><issue>11</issue><spage>867</spage><epage>870</epage><pages>867-870</pages><issn>0019-6061</issn><eissn>0974-7559</eissn><abstract>Objective
The aim of this study was to evaluate the features of asymptomatic siblings of index celiac patients who were diagnosed with celiac disease (CD) at the initial screening.
Methods
We reviewed hospital records of 210 children with CD. The characteristics of sibling celiacs (
n
=24) were compared with index celiacs (
n
=186).
Results
At diagnosis, sibling celiacs were older than index celiacs (mean (SD) 10.4 (2.7) vs 8.2 (4.3) years; P=0.02). There were no significant differences between sibling and index celiacs in terms of serum anti-tTG IgA titer (≥10xULN, 83.3% vs 85%), and most of the patients had moderate/severe villous atrophy in both groups. The rates of iron deficiency anemia, folic acid deficiency, wasting and stunting were comparable between sibling and index celiac patients.
Conclusions
Siblings with CD were older than index children with CD at diagnosis, and their characteristics were similar to symptomatic index children with CD, despite not having any complaints.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s13312-022-2645-8</doi><tpages>4</tpages></addata></record> |
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| source | SpringerNature Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Maternal and Child Health Medicine Medicine & Public Health Pediatric Surgery Pediatrics Research Paper |
| title | Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening |
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