Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia
A significant amount of evidence from the past few years has shown that Sirtuin 1 (SIRT1), a histone deacetylase dinucleotide of nicotinamide adenine dinucleotide (NAD + ) is closely related to the cerebral ischemia. Several potential neuroprotective strategies like resveratrol, ischemia preconditio...
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| Veröffentlicht in: | Cellular and molecular neurobiology 2023-07, Vol.43 (5), p.1769-1783 |
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| container_title | Cellular and molecular neurobiology |
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| creator | Fangma, Yijia Wan, Haitong Shao, Chongyu Jin, Liang He, Yu |
| description | A significant amount of evidence from the past few years has shown that Sirtuin 1 (SIRT1), a histone deacetylase dinucleotide of nicotinamide adenine dinucleotide (NAD
+
) is closely related to the cerebral ischemia. Several potential neuroprotective strategies like resveratrol, ischemia preconditioning, and caloric restriction exert their neuroprotection effects through SIRT1-related signaling pathway. However, the potential mechanisms and neuroprotection of SIRT1 in the process of cerebral ischemia injury development and recovery have not been systematically elaborated. This review summarized the the deacetylase activity and distribution of SIRT1 as well as analyzed the roles of SIRT1 in astrocytes, microglia, neurons, and brain microvascular endothelial cells (BMECs), and the molecular mechanisms of SIRT1 in cerebral ischemia, providing a theoretical basis for exploration of new therapeutic target in future. |
| doi_str_mv | 10.1007/s10571-022-01288-3 |
| format | Article |
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This review summarized the the deacetylase activity and distribution of SIRT1 as well as analyzed the roles of SIRT1 in astrocytes, microglia, neurons, and brain microvascular endothelial cells (BMECs), and the molecular mechanisms of SIRT1 in cerebral ischemia, providing a theoretical basis for exploration of new therapeutic target in future.</description><subject>Astrocytes</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Dietary restrictions</subject><subject>Endothelial cells</subject><subject>Histone deacetylase</subject><subject>Ischemia</subject><subject>Microglia</subject><subject>Microvasculature</subject><subject>Molecular modelling</subject><subject>NAD</subject><subject>Neurobiology</subject><subject>Neuroprotection</subject><subject>Neurosciences</subject><subject>Resveratrol</subject><subject>Review Paper</subject><subject>Signal transduction</subject><subject>SIRT1 protein</subject><subject>Therapeutic targets</subject><issn>0272-4340</issn><issn>1573-6830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kMFu2zAMhoVhxZJ1e4EeBgG77OKWEi3JOhVF0G0FCnRIcxdkmU4cOHYqxYe-fbWmXYEdeiEP_PiT-Bg7E3AuAMxFEqCMKEDKAoSsqgI_sLlQBgtdIXxkc5BGFiWWMGOfU9oCgAVQn9gMtVBYGpyzyyUl8jFs-J84riOlxMeBHzbEl2NPfGz5fRcPUzdwwXNZUKQ6-p7fpLChXee_sJPW94m-vvRTtvp5vVr8Lm7vft0srm6LgEYditqXgBi0AtkA6dD4Ujey8a1Bq-vQovIULBmL0irZmlprQmqtlaaVlcdT9uMYu4_jw0Tp4HZdCtT3fqBxSk4aYbRVgDaj3_9Dt-MUh_yck1W2VFmlTabkkQpxTClS6_ax2_n46AS4v3bd0a7Ldt2zXYd56dtL9FTvqPm38qozA3gEUh4Na4pvt9-JfQKJooLY</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Fangma, Yijia</creator><creator>Wan, Haitong</creator><creator>Shao, Chongyu</creator><creator>Jin, Liang</creator><creator>He, Yu</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5726-7214</orcidid><orcidid>https://orcid.org/0000-0002-5101-6008</orcidid><orcidid>https://orcid.org/0000-0002-1993-1257</orcidid><orcidid>https://orcid.org/0000-0002-5532-1448</orcidid><orcidid>https://orcid.org/0000-0003-0110-287X</orcidid></search><sort><creationdate>20230701</creationdate><title>Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia</title><author>Fangma, Yijia ; Wan, Haitong ; Shao, Chongyu ; Jin, Liang ; He, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ba4033c6502d0e6cda46d2daf7396bcf35aec9e7932952f7b66e3ef9927f28a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Astrocytes</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Dietary restrictions</topic><topic>Endothelial cells</topic><topic>Histone deacetylase</topic><topic>Ischemia</topic><topic>Microglia</topic><topic>Microvasculature</topic><topic>Molecular modelling</topic><topic>NAD</topic><topic>Neurobiology</topic><topic>Neuroprotection</topic><topic>Neurosciences</topic><topic>Resveratrol</topic><topic>Review Paper</topic><topic>Signal transduction</topic><topic>SIRT1 protein</topic><topic>Therapeutic targets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fangma, Yijia</creatorcontrib><creatorcontrib>Wan, Haitong</creatorcontrib><creatorcontrib>Shao, Chongyu</creatorcontrib><creatorcontrib>Jin, Liang</creatorcontrib><creatorcontrib>He, Yu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular and molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fangma, Yijia</au><au>Wan, Haitong</au><au>Shao, Chongyu</au><au>Jin, Liang</au><au>He, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia</atitle><jtitle>Cellular and molecular neurobiology</jtitle><stitle>Cell Mol Neurobiol</stitle><addtitle>Cell Mol Neurobiol</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>43</volume><issue>5</issue><spage>1769</spage><epage>1783</epage><pages>1769-1783</pages><issn>0272-4340</issn><eissn>1573-6830</eissn><abstract>A significant amount of evidence from the past few years has shown that Sirtuin 1 (SIRT1), a histone deacetylase dinucleotide of nicotinamide adenine dinucleotide (NAD
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| subjects | Astrocytes Biomedical and Life Sciences Biomedicine Cell Biology Dietary restrictions Endothelial cells Histone deacetylase Ischemia Microglia Microvasculature Molecular modelling NAD Neurobiology Neuroprotection Neurosciences Resveratrol Review Paper Signal transduction SIRT1 protein Therapeutic targets |
| title | Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia |
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