Development and validation of a gene model predicting lymph node metastasis and prognosis of oral squamous cell carcinoma based on single‐cell and bulk RNA‐seq analysis

Background Lymph node metastasis can independently predict oral squamous cell carcinoma patients' survival. This study would investigate the genetic and cellular differences between oral squamous cell carcinoma with positive and negative lymph node metastases. Methods We gathered single‐cell RN...

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Veröffentlicht in:	Journal of oral pathology & medicine 2023-05, Vol.52 (5), p.389-401
Hauptverfasser:	Han, Pei‐Zhen, Tan, Li‐Cheng, Ouyang, Qing‐Si, Yu, Peng‐Cheng, Shi, Xiao, Hu, Jia‐Qian, Wei, Wen‐Jun, Lu, Zhong‐Wu, Wang, Yu, Ji, Qing‐Hai, Qu, Ning, Mai, Hua‐Ming, Wang, Yu‐Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic drugs Antitumor agents Cancer Carcinoma, Squamous Cell - pathology Cell survival Gene expression Genomes Head and Neck Neoplasms Humans Immunosuppressive agents Immunotherapy Infiltration lymph node metastasis Lymph nodes Lymphatic Metastasis - genetics Lymphatic system Medical prognosis Metastases Metastasis Mouth Neoplasms - genetics Mouth Neoplasms - pathology Oral cancer Oral carcinoma Oral squamous cell carcinoma Patients Prognosis Ribonucleic acid Risk groups RNA RNA-Seq single‐cell RNA sequencing Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck tumor microenvironment
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