Early echocardiographic evaluation of right ventricular load adaptability after sequential combination treatment in pulmonary arterial hypertension
Background Using the tricuspid annular plane systolic excursion (TAPSE)/pulmonary arterial systolic pressure (PASP) ratio as an index of right ventricular load adaptability, we aimed to evaluate early changes in right heart contractile function of patients with group 1 pulmonary artery hypertension...
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| Veröffentlicht in: | Herz 2023-08, Vol.48 (4), p.316-324 |
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| creator | Memic Sancar, Kadriye Yildiz, Mustafa Kahraman, Serkan Uygur, Begum Bulut, Umit Tekin, Meltem Guler, Arda Serbest, Nail Guven Tukenmez Karakurt, Seda Sahin Yildiz, Banu Cizgici, Ahmet Yasar Bayram, Muhammed Erturk, Mehmet |
| description | Background
Using the tricuspid annular plane systolic excursion (TAPSE)/pulmonary arterial systolic pressure (PASP) ratio as an index of right ventricular load adaptability, we aimed to evaluate early changes in right heart contractile function of patients with group 1 pulmonary artery hypertension (PAH) after sequential combination PAH-specific therapy.
Methods
A total of 49 patients with group 1 PAH and 31 control participants were included in the study. The baseline clinical and echocardiographic data of the control and PAH group were compared. Subsequently, clinical and echocardiographic data of PAH patients before treatment and at 6 months after PAH-specific treatment were analyzed.
Results
A significant increase in the TAPSE/PASP ratio was found in patients at 6 months of PAH-specific treatment (0.25 ± 0.14; 0.33 ± 0.16,
p
|
| doi_str_mv | 10.1007/s00059-022-05139-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2717692928</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2717692928</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-66484747344e77637574cfd672192a6ee2edb683bfc41c9ad32701dfb4dec8183</originalsourceid><addsrcrecordid>eNp9kU1vFSEUhonR2NvWP-DCkLhxM5avgWFpmvqRNHHTrgkDzL00DIzANLm_o39YrlM1ceHqkJznfc85vAC8xegjRkhcFYRQLztESId6TGWHX4Ad5rjvOJfkJdghylAnJRVn4LyUB4RwLwl6Dc4ox0yynu7A043O4QidOSSjs_Vpn_Vy8Aa6Rx1WXX2KME0w-_2hwkcXa_ZmDTrDkLSF2uql6tEHX49QT9VlWNyPtWFeB2jSPPq4edTsdJ1bA_oIlzXMKercNLlpTuzhuLj2jqXBl-DVpENxb57rBbj_fHN3_bW7_f7l2_Wn285Qwms7kg1MMEEZc0JwKnrBzGS5IFgSzZ0jzo58oONkGDZSW0oEwnYamXVmwAO9AB823yWntnSpavbFuBB0dGktiggs2kdKckLf_4M-pDXHtp0iA6OyxxiLRpGNMjmVkt2kluzndqfCSJ0iU1tkqkWmfkWmcBO9e7Zex9nZP5LfGTWAbkBprbh3-e_s_9j-BOlKpVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2843951117</pqid></control><display><type>article</type><title>Early echocardiographic evaluation of right ventricular load adaptability after sequential combination treatment in pulmonary arterial hypertension</title><source>Springer Nature - Complete Springer Journals</source><creator>Memic Sancar, Kadriye ; Yildiz, Mustafa ; Kahraman, Serkan ; Uygur, Begum ; Bulut, Umit ; Tekin, Meltem ; Guler, Arda ; Serbest, Nail Guven ; Tukenmez Karakurt, Seda ; Sahin Yildiz, Banu ; Cizgici, Ahmet Yasar ; Bayram, Muhammed ; Erturk, Mehmet</creator><creatorcontrib>Memic Sancar, Kadriye ; Yildiz, Mustafa ; Kahraman, Serkan ; Uygur, Begum ; Bulut, Umit ; Tekin, Meltem ; Guler, Arda ; Serbest, Nail Guven ; Tukenmez Karakurt, Seda ; Sahin Yildiz, Banu ; Cizgici, Ahmet Yasar ; Bayram, Muhammed ; Erturk, Mehmet</creatorcontrib><description>Background
Using the tricuspid annular plane systolic excursion (TAPSE)/pulmonary arterial systolic pressure (PASP) ratio as an index of right ventricular load adaptability, we aimed to evaluate early changes in right heart contractile function of patients with group 1 pulmonary artery hypertension (PAH) after sequential combination PAH-specific therapy.
Methods
A total of 49 patients with group 1 PAH and 31 control participants were included in the study. The baseline clinical and echocardiographic data of the control and PAH group were compared. Subsequently, clinical and echocardiographic data of PAH patients before treatment and at 6 months after PAH-specific treatment were analyzed.
Results
A significant increase in the TAPSE/PASP ratio was found in patients at 6 months of PAH-specific treatment (0.25 ± 0.14; 0.33 ± 0.16,
p
< 0.001). Right atrial pressure (8 mm Hg [5–10]; 5 mm Hg [3–8],
p
< 0.001) and PASP (80.8 ± 30.6 mm Hg; 65.9 ± 25.7 mm Hg,
p
< 0.001) were significantly lower after sequential combination PAH-specific therapy. Negative correlations were found between the TAPSE/PASP ratio and N‑terminal pro-B-type natriuretic peptide (
r
= −0.524,
p
< 0.001), tricuspid regurgitation velocity (
r
= −0.749,
p
< 0.001), right atrial area (
r
= −0.298,
p
= 0.037), and right atrial pressure (
r
= −0.463,
p
= 0.001).
Conclusion
In patients with group 1 PAH, echocardiographic evaluation at the early stage of treatment (6 months) shows a significant improvement in the TAPSE/PASP ratio indicating right ventricular load adaptation. Comprehensive studies are needed on the routine use of the TAPSE/PASP ratio in the risk assessment of PAH patients.</description><identifier>ISSN: 0340-9937</identifier><identifier>EISSN: 1615-6692</identifier><identifier>DOI: 10.1007/s00059-022-05139-1</identifier><identifier>PMID: 36149453</identifier><language>eng</language><publisher>Heidelberg: Springer Medizin</publisher><subject>Adaptability ; Blood pressure ; Brain natriuretic peptide ; Cardiology ; Heart ; Hypertension ; Internal Medicine ; Medicine ; Medicine & Public Health ; Muscle contraction ; Original Articles ; Patients ; Peptides ; Pulmonary arteries ; Pulmonary artery ; Regurgitation ; Risk assessment ; Systolic pressure ; Ventricle</subject><ispartof>Herz, 2023-08, Vol.48 (4), p.316-324</ispartof><rights>The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-66484747344e77637574cfd672192a6ee2edb683bfc41c9ad32701dfb4dec8183</cites><orcidid>0000-0003-1350-215X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00059-022-05139-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00059-022-05139-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36149453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Memic Sancar, Kadriye</creatorcontrib><creatorcontrib>Yildiz, Mustafa</creatorcontrib><creatorcontrib>Kahraman, Serkan</creatorcontrib><creatorcontrib>Uygur, Begum</creatorcontrib><creatorcontrib>Bulut, Umit</creatorcontrib><creatorcontrib>Tekin, Meltem</creatorcontrib><creatorcontrib>Guler, Arda</creatorcontrib><creatorcontrib>Serbest, Nail Guven</creatorcontrib><creatorcontrib>Tukenmez Karakurt, Seda</creatorcontrib><creatorcontrib>Sahin Yildiz, Banu</creatorcontrib><creatorcontrib>Cizgici, Ahmet Yasar</creatorcontrib><creatorcontrib>Bayram, Muhammed</creatorcontrib><creatorcontrib>Erturk, Mehmet</creatorcontrib><title>Early echocardiographic evaluation of right ventricular load adaptability after sequential combination treatment in pulmonary arterial hypertension</title><title>Herz</title><addtitle>Herz</addtitle><addtitle>Herz</addtitle><description>Background
Using the tricuspid annular plane systolic excursion (TAPSE)/pulmonary arterial systolic pressure (PASP) ratio as an index of right ventricular load adaptability, we aimed to evaluate early changes in right heart contractile function of patients with group 1 pulmonary artery hypertension (PAH) after sequential combination PAH-specific therapy.
Methods
A total of 49 patients with group 1 PAH and 31 control participants were included in the study. The baseline clinical and echocardiographic data of the control and PAH group were compared. Subsequently, clinical and echocardiographic data of PAH patients before treatment and at 6 months after PAH-specific treatment were analyzed.
Results
A significant increase in the TAPSE/PASP ratio was found in patients at 6 months of PAH-specific treatment (0.25 ± 0.14; 0.33 ± 0.16,
p
< 0.001). Right atrial pressure (8 mm Hg [5–10]; 5 mm Hg [3–8],
p
< 0.001) and PASP (80.8 ± 30.6 mm Hg; 65.9 ± 25.7 mm Hg,
p
< 0.001) were significantly lower after sequential combination PAH-specific therapy. Negative correlations were found between the TAPSE/PASP ratio and N‑terminal pro-B-type natriuretic peptide (
r
= −0.524,
p
< 0.001), tricuspid regurgitation velocity (
r
= −0.749,
p
< 0.001), right atrial area (
r
= −0.298,
p
= 0.037), and right atrial pressure (
r
= −0.463,
p
= 0.001).
Conclusion
In patients with group 1 PAH, echocardiographic evaluation at the early stage of treatment (6 months) shows a significant improvement in the TAPSE/PASP ratio indicating right ventricular load adaptation. Comprehensive studies are needed on the routine use of the TAPSE/PASP ratio in the risk assessment of PAH patients.</description><subject>Adaptability</subject><subject>Blood pressure</subject><subject>Brain natriuretic peptide</subject><subject>Cardiology</subject><subject>Heart</subject><subject>Hypertension</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscle contraction</subject><subject>Original Articles</subject><subject>Patients</subject><subject>Peptides</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Regurgitation</subject><subject>Risk assessment</subject><subject>Systolic pressure</subject><subject>Ventricle</subject><issn>0340-9937</issn><issn>1615-6692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kU1vFSEUhonR2NvWP-DCkLhxM5avgWFpmvqRNHHTrgkDzL00DIzANLm_o39YrlM1ceHqkJznfc85vAC8xegjRkhcFYRQLztESId6TGWHX4Ad5rjvOJfkJdghylAnJRVn4LyUB4RwLwl6Dc4ox0yynu7A043O4QidOSSjs_Vpn_Vy8Aa6Rx1WXX2KME0w-_2hwkcXa_ZmDTrDkLSF2uql6tEHX49QT9VlWNyPtWFeB2jSPPq4edTsdJ1bA_oIlzXMKercNLlpTuzhuLj2jqXBl-DVpENxb57rBbj_fHN3_bW7_f7l2_Wn285Qwms7kg1MMEEZc0JwKnrBzGS5IFgSzZ0jzo58oONkGDZSW0oEwnYamXVmwAO9AB823yWntnSpavbFuBB0dGktiggs2kdKckLf_4M-pDXHtp0iA6OyxxiLRpGNMjmVkt2kluzndqfCSJ0iU1tkqkWmfkWmcBO9e7Zex9nZP5LfGTWAbkBprbh3-e_s_9j-BOlKpVA</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Memic Sancar, Kadriye</creator><creator>Yildiz, Mustafa</creator><creator>Kahraman, Serkan</creator><creator>Uygur, Begum</creator><creator>Bulut, Umit</creator><creator>Tekin, Meltem</creator><creator>Guler, Arda</creator><creator>Serbest, Nail Guven</creator><creator>Tukenmez Karakurt, Seda</creator><creator>Sahin Yildiz, Banu</creator><creator>Cizgici, Ahmet Yasar</creator><creator>Bayram, Muhammed</creator><creator>Erturk, Mehmet</creator><general>Springer Medizin</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1350-215X</orcidid></search><sort><creationdate>20230801</creationdate><title>Early echocardiographic evaluation of right ventricular load adaptability after sequential combination treatment in pulmonary arterial hypertension</title><author>Memic Sancar, Kadriye ; Yildiz, Mustafa ; Kahraman, Serkan ; Uygur, Begum ; Bulut, Umit ; Tekin, Meltem ; Guler, Arda ; Serbest, Nail Guven ; Tukenmez Karakurt, Seda ; Sahin Yildiz, Banu ; Cizgici, Ahmet Yasar ; Bayram, Muhammed ; Erturk, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-66484747344e77637574cfd672192a6ee2edb683bfc41c9ad32701dfb4dec8183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adaptability</topic><topic>Blood pressure</topic><topic>Brain natriuretic peptide</topic><topic>Cardiology</topic><topic>Heart</topic><topic>Hypertension</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscle contraction</topic><topic>Original Articles</topic><topic>Patients</topic><topic>Peptides</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Regurgitation</topic><topic>Risk assessment</topic><topic>Systolic pressure</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Memic Sancar, Kadriye</creatorcontrib><creatorcontrib>Yildiz, Mustafa</creatorcontrib><creatorcontrib>Kahraman, Serkan</creatorcontrib><creatorcontrib>Uygur, Begum</creatorcontrib><creatorcontrib>Bulut, Umit</creatorcontrib><creatorcontrib>Tekin, Meltem</creatorcontrib><creatorcontrib>Guler, Arda</creatorcontrib><creatorcontrib>Serbest, Nail Guven</creatorcontrib><creatorcontrib>Tukenmez Karakurt, Seda</creatorcontrib><creatorcontrib>Sahin Yildiz, Banu</creatorcontrib><creatorcontrib>Cizgici, Ahmet Yasar</creatorcontrib><creatorcontrib>Bayram, Muhammed</creatorcontrib><creatorcontrib>Erturk, Mehmet</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Herz</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Memic Sancar, Kadriye</au><au>Yildiz, Mustafa</au><au>Kahraman, Serkan</au><au>Uygur, Begum</au><au>Bulut, Umit</au><au>Tekin, Meltem</au><au>Guler, Arda</au><au>Serbest, Nail Guven</au><au>Tukenmez Karakurt, Seda</au><au>Sahin Yildiz, Banu</au><au>Cizgici, Ahmet Yasar</au><au>Bayram, Muhammed</au><au>Erturk, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early echocardiographic evaluation of right ventricular load adaptability after sequential combination treatment in pulmonary arterial hypertension</atitle><jtitle>Herz</jtitle><stitle>Herz</stitle><addtitle>Herz</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>48</volume><issue>4</issue><spage>316</spage><epage>324</epage><pages>316-324</pages><issn>0340-9937</issn><eissn>1615-6692</eissn><abstract>Background
Using the tricuspid annular plane systolic excursion (TAPSE)/pulmonary arterial systolic pressure (PASP) ratio as an index of right ventricular load adaptability, we aimed to evaluate early changes in right heart contractile function of patients with group 1 pulmonary artery hypertension (PAH) after sequential combination PAH-specific therapy.
Methods
A total of 49 patients with group 1 PAH and 31 control participants were included in the study. The baseline clinical and echocardiographic data of the control and PAH group were compared. Subsequently, clinical and echocardiographic data of PAH patients before treatment and at 6 months after PAH-specific treatment were analyzed.
Results
A significant increase in the TAPSE/PASP ratio was found in patients at 6 months of PAH-specific treatment (0.25 ± 0.14; 0.33 ± 0.16,
p
< 0.001). Right atrial pressure (8 mm Hg [5–10]; 5 mm Hg [3–8],
p
< 0.001) and PASP (80.8 ± 30.6 mm Hg; 65.9 ± 25.7 mm Hg,
p
< 0.001) were significantly lower after sequential combination PAH-specific therapy. Negative correlations were found between the TAPSE/PASP ratio and N‑terminal pro-B-type natriuretic peptide (
r
= −0.524,
p
< 0.001), tricuspid regurgitation velocity (
r
= −0.749,
p
< 0.001), right atrial area (
r
= −0.298,
p
= 0.037), and right atrial pressure (
r
= −0.463,
p
= 0.001).
Conclusion
In patients with group 1 PAH, echocardiographic evaluation at the early stage of treatment (6 months) shows a significant improvement in the TAPSE/PASP ratio indicating right ventricular load adaptation. Comprehensive studies are needed on the routine use of the TAPSE/PASP ratio in the risk assessment of PAH patients.</abstract><cop>Heidelberg</cop><pub>Springer Medizin</pub><pmid>36149453</pmid><doi>10.1007/s00059-022-05139-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1350-215X</orcidid></addata></record> |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Adaptability Blood pressure Brain natriuretic peptide Cardiology Heart Hypertension Internal Medicine Medicine Medicine & Public Health Muscle contraction Original Articles Patients Peptides Pulmonary arteries Pulmonary artery Regurgitation Risk assessment Systolic pressure Ventricle |
| title | Early echocardiographic evaluation of right ventricular load adaptability after sequential combination treatment in pulmonary arterial hypertension |
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