Exercise improves testicular morphology and oxidative stress parameters in rats with testicular damage induced by a high‐fat diet
Obesity and male infertility are problems that affect population. Exercise is a nonpharmacological way to reduce the negative health effects of obesity. The purpose of this study was to examine the effects of exercise on hormone levels, blood‐testis barrier, and inflammatory and oxidative biomarkers...
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| Veröffentlicht in: | Andrologia 2022-12, Vol.54 (11), p.e14600-n/a |
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| creator | Elmas, Merve Acikel Ozakpinar, Ozlem Bingol Kolgazi, Meltem Sener, Goksel Arbak, Serap Ercan, Feriha |
| description | Obesity and male infertility are problems that affect population. Exercise is a nonpharmacological way to reduce the negative health effects of obesity. The purpose of this study was to examine the effects of exercise on hormone levels, blood‐testis barrier, and inflammatory and oxidative biomarkers in rats that became obese due to a high‐fat diet (HFD). Male rats received a standard diet (STD group) or a HFD (HFD group) for 18 weeks. During the final 6 weeks of the experiment, swimming exercises (1 h/5 days/week) were given to half of these animals (STD + EXC and HFD + EXC groups). Finally, blood and testicular tissues were analysed by biochemical and histological methods. Body weight, leptin, malondialdehyde, interleukin‐6, TNF‐alpha and myeloperoxidase levels, apoptotic cells and DNA fragmentation were increased, and testis weight, insulin, FSH, LH, testosterone, glutathione and superoxide dysmutase levels, proliferative cells, ZO‐1, occludin, and gap junction protein Cx43 immunoreactivity were decreased in the HFD group. All these hormonal, morphological, oxidative and inflammatory biomarkers were enhanced in the HFD + EXC group. It is thought that exercise protected testicular cytotoxicity by regulating hormonal and oxidant/antioxidant balances and testicular function, inhibiting inflammation and apoptosis, as well as preserving blood‐testis barrier. |
| doi_str_mv | 10.1111/and.14600 |
| format | Article |
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Exercise is a nonpharmacological way to reduce the negative health effects of obesity. The purpose of this study was to examine the effects of exercise on hormone levels, blood‐testis barrier, and inflammatory and oxidative biomarkers in rats that became obese due to a high‐fat diet (HFD). Male rats received a standard diet (STD group) or a HFD (HFD group) for 18 weeks. During the final 6 weeks of the experiment, swimming exercises (1 h/5 days/week) were given to half of these animals (STD + EXC and HFD + EXC groups). Finally, blood and testicular tissues were analysed by biochemical and histological methods. Body weight, leptin, malondialdehyde, interleukin‐6, TNF‐alpha and myeloperoxidase levels, apoptotic cells and DNA fragmentation were increased, and testis weight, insulin, FSH, LH, testosterone, glutathione and superoxide dysmutase levels, proliferative cells, ZO‐1, occludin, and gap junction protein Cx43 immunoreactivity were decreased in the HFD group. All these hormonal, morphological, oxidative and inflammatory biomarkers were enhanced in the HFD + EXC group. It is thought that exercise protected testicular cytotoxicity by regulating hormonal and oxidant/antioxidant balances and testicular function, inhibiting inflammation and apoptosis, as well as preserving blood‐testis barrier.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.14600</identifier><identifier>PMID: 36146902</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Apoptosis ; Biomarkers ; Biomarkers - metabolism ; Blood levels ; blood testis barrier ; Body weight ; Connexin 43 ; Cytotoxicity ; Diet, High-Fat - adverse effects ; DNA fragmentation ; exercise ; Follicle-stimulating hormone ; Glutathione ; High fat diet ; Immunoreactivity ; Infertility ; Inflammation ; Insulin ; Interleukin 6 ; Leptin ; Luteinizing hormone ; Male ; Obesity ; Obesity - metabolism ; Oxidants ; Oxidative stress ; Oxidative Stress - physiology ; Peroxidase ; Physical Conditioning, Animal - physiology ; Physical training ; Rats ; Testes ; Testis - metabolism ; Testosterone ; Tumor necrosis factor ; ultrastructure</subject><ispartof>Andrologia, 2022-12, Vol.54 (11), p.e14600-n/a</ispartof><rights>2022 Wiley‐VCH GmbH.</rights><rights>2022 Wiley-VCH GmbH.</rights><rights>2022 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3880-a47e74cfde69a8b342f1d692a86ae3f2c0af0368620e12498b3eeff5dedf661b3</citedby><cites>FETCH-LOGICAL-c3880-a47e74cfde69a8b342f1d692a86ae3f2c0af0368620e12498b3eeff5dedf661b3</cites><orcidid>0000-0001-6279-9602 ; 0000-0003-2339-5669</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.14600$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.14600$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36146902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elmas, Merve Acikel</creatorcontrib><creatorcontrib>Ozakpinar, Ozlem Bingol</creatorcontrib><creatorcontrib>Kolgazi, Meltem</creatorcontrib><creatorcontrib>Sener, Goksel</creatorcontrib><creatorcontrib>Arbak, Serap</creatorcontrib><creatorcontrib>Ercan, Feriha</creatorcontrib><title>Exercise improves testicular morphology and oxidative stress parameters in rats with testicular damage induced by a high‐fat diet</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Obesity and male infertility are problems that affect population. Exercise is a nonpharmacological way to reduce the negative health effects of obesity. The purpose of this study was to examine the effects of exercise on hormone levels, blood‐testis barrier, and inflammatory and oxidative biomarkers in rats that became obese due to a high‐fat diet (HFD). Male rats received a standard diet (STD group) or a HFD (HFD group) for 18 weeks. During the final 6 weeks of the experiment, swimming exercises (1 h/5 days/week) were given to half of these animals (STD + EXC and HFD + EXC groups). Finally, blood and testicular tissues were analysed by biochemical and histological methods. Body weight, leptin, malondialdehyde, interleukin‐6, TNF‐alpha and myeloperoxidase levels, apoptotic cells and DNA fragmentation were increased, and testis weight, insulin, FSH, LH, testosterone, glutathione and superoxide dysmutase levels, proliferative cells, ZO‐1, occludin, and gap junction protein Cx43 immunoreactivity were decreased in the HFD group. All these hormonal, morphological, oxidative and inflammatory biomarkers were enhanced in the HFD + EXC group. It is thought that exercise protected testicular cytotoxicity by regulating hormonal and oxidant/antioxidant balances and testicular function, inhibiting inflammation and apoptosis, as well as preserving blood‐testis barrier.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Blood levels</subject><subject>blood testis barrier</subject><subject>Body weight</subject><subject>Connexin 43</subject><subject>Cytotoxicity</subject><subject>Diet, High-Fat - adverse effects</subject><subject>DNA fragmentation</subject><subject>exercise</subject><subject>Follicle-stimulating hormone</subject><subject>Glutathione</subject><subject>High fat diet</subject><subject>Immunoreactivity</subject><subject>Infertility</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Interleukin 6</subject><subject>Leptin</subject><subject>Luteinizing hormone</subject><subject>Male</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Oxidants</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Peroxidase</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physical training</subject><subject>Rats</subject><subject>Testes</subject><subject>Testis - metabolism</subject><subject>Testosterone</subject><subject>Tumor necrosis factor</subject><subject>ultrastructure</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1OGzEQxy0Egojm0BdAlrjQw4K_4vUeEaUtEioXel5N1uPEaD9S2wvkhsQL9Bn7JHWbgCok5jKXn38z4z8hHzk75bnOoLenXGnGdsiEK1kVTJRil0yYZLJQM10dkGmMdyyXmpWlUvvkQOr8omJiQp4vHzE0PiL13SoM9xhpwph8M7YQaDeE1XJoh8Wa5jF0ePQWkr9HGlPAGOkKAnSYMETqexogRfrg0_J_hYUOFtne27FBS-fZRJd-sfz99MtBotZj-kD2HLQRp9t-SH58uby9-FZc33y9uji_LhppDCtAlViqxlnUFZi5VMJxqysBRgNKJxoGjklttGDIhaoygujczKJ1WvO5PCQnG28-9OeYV6w7HxtsW-hxGGMtSl5qY0ohM3r8Br0bxtDn7TKlhDFaM5OpTxuqCUOMAV29Cr6DsK45q_-GU-dfq_-Fk9mjrXGcd2hfyZcoMnC2AR58i-v3TfX5988b5R-yXJuX</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Elmas, Merve Acikel</creator><creator>Ozakpinar, Ozlem Bingol</creator><creator>Kolgazi, Meltem</creator><creator>Sener, Goksel</creator><creator>Arbak, Serap</creator><creator>Ercan, Feriha</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6279-9602</orcidid><orcidid>https://orcid.org/0000-0003-2339-5669</orcidid></search><sort><creationdate>202212</creationdate><title>Exercise improves testicular morphology and oxidative stress parameters in rats with testicular damage induced by a high‐fat diet</title><author>Elmas, Merve Acikel ; Ozakpinar, Ozlem Bingol ; Kolgazi, Meltem ; Sener, Goksel ; Arbak, Serap ; Ercan, Feriha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-a47e74cfde69a8b342f1d692a86ae3f2c0af0368620e12498b3eeff5dedf661b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Blood levels</topic><topic>blood testis barrier</topic><topic>Body weight</topic><topic>Connexin 43</topic><topic>Cytotoxicity</topic><topic>Diet, High-Fat - adverse effects</topic><topic>DNA fragmentation</topic><topic>exercise</topic><topic>Follicle-stimulating hormone</topic><topic>Glutathione</topic><topic>High fat diet</topic><topic>Immunoreactivity</topic><topic>Infertility</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Interleukin 6</topic><topic>Leptin</topic><topic>Luteinizing hormone</topic><topic>Male</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Oxidants</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Peroxidase</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Physical training</topic><topic>Rats</topic><topic>Testes</topic><topic>Testis - metabolism</topic><topic>Testosterone</topic><topic>Tumor necrosis factor</topic><topic>ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elmas, Merve Acikel</creatorcontrib><creatorcontrib>Ozakpinar, Ozlem Bingol</creatorcontrib><creatorcontrib>Kolgazi, Meltem</creatorcontrib><creatorcontrib>Sener, Goksel</creatorcontrib><creatorcontrib>Arbak, Serap</creatorcontrib><creatorcontrib>Ercan, Feriha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elmas, Merve Acikel</au><au>Ozakpinar, Ozlem Bingol</au><au>Kolgazi, Meltem</au><au>Sener, Goksel</au><au>Arbak, Serap</au><au>Ercan, Feriha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise improves testicular morphology and oxidative stress parameters in rats with testicular damage induced by a high‐fat diet</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2022-12</date><risdate>2022</risdate><volume>54</volume><issue>11</issue><spage>e14600</spage><epage>n/a</epage><pages>e14600-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Obesity and male infertility are problems that affect population. Exercise is a nonpharmacological way to reduce the negative health effects of obesity. The purpose of this study was to examine the effects of exercise on hormone levels, blood‐testis barrier, and inflammatory and oxidative biomarkers in rats that became obese due to a high‐fat diet (HFD). Male rats received a standard diet (STD group) or a HFD (HFD group) for 18 weeks. During the final 6 weeks of the experiment, swimming exercises (1 h/5 days/week) were given to half of these animals (STD + EXC and HFD + EXC groups). Finally, blood and testicular tissues were analysed by biochemical and histological methods. Body weight, leptin, malondialdehyde, interleukin‐6, TNF‐alpha and myeloperoxidase levels, apoptotic cells and DNA fragmentation were increased, and testis weight, insulin, FSH, LH, testosterone, glutathione and superoxide dysmutase levels, proliferative cells, ZO‐1, occludin, and gap junction protein Cx43 immunoreactivity were decreased in the HFD group. 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| subjects | Animals Apoptosis Biomarkers Biomarkers - metabolism Blood levels blood testis barrier Body weight Connexin 43 Cytotoxicity Diet, High-Fat - adverse effects DNA fragmentation exercise Follicle-stimulating hormone Glutathione High fat diet Immunoreactivity Infertility Inflammation Insulin Interleukin 6 Leptin Luteinizing hormone Male Obesity Obesity - metabolism Oxidants Oxidative stress Oxidative Stress - physiology Peroxidase Physical Conditioning, Animal - physiology Physical training Rats Testes Testis - metabolism Testosterone Tumor necrosis factor ultrastructure |
| title | Exercise improves testicular morphology and oxidative stress parameters in rats with testicular damage induced by a high‐fat diet |
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