Human antimicrobial peptide LL-37 contributes to Alzheimer’s disease progression

As a prime mover in Alzheimer’s disease (AD), microglial activation requires membrane translocation, integration, and activation of the metamorphic protein chloride intracellular channel 1 (CLIC1), which is primarily cytoplasmic under physiological conditions. However, the formation and activation m...

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Veröffentlicht in:	Molecular psychiatry 2022-11, Vol.27 (11), p.4790-4799
Hauptverfasser:	Chen, Xue, Deng, Suixin, Wang, Wenchao, Castiglione, Stefania, Duan, Zilei, Luo, Lei, Cianci, Francesca, Zhang, Xiaoxue, Xu, Jianglei, Li, Hao, Zhao, Jizong, Kamau, Peter Muiruri, Zhang, Zhiye, Mwangi, James, Li, Jiali, Shu, Yousheng, Hu, Xintian, Mazzanti, Michele, Lai, Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/2 13/21 13/51 14/19 631/378 631/80 64/110 64/60 Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Animal models Animals Antimicrobial agents Antimicrobial peptides Atrophy Behavioral Sciences Biological Psychology Cathelicidins - metabolism Cathelicidins - pharmacology Chloride Channels - metabolism Cognition Excitotoxicity Humans Inflammation Medicine Medicine & Public Health Mice Microglia - metabolism Neurodegenerative diseases Neurofibrillary tangles Neurosciences Peptides Pharmacotherapy Phenotypes Psychiatry Synaptic plasticity Ventricle (lateral) β-Amyloid
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