A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer

The chromatin-modifying enzyme ATAD2 confers oncogenic competence and proliferative advantage in malignances. We previously identified ATAD2 as a marker and driver of cell proliferation in ovarian cancer (OC); however, the mechanisms whereby ATAD2 is regulated and involved in cell proliferation are...

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Veröffentlicht in:	Cancer gene therapy 2023-01, Vol.30 (1), p.192-208
Hauptverfasser:	Liu, Qun, Liu, Heshu, Huang, Xuying, Fan, Xiaona, Xiao, Zeru, Yan, Rui, Yao, Jiannan, An, Guanyu, Ge, Yang, Miao, Jinwei, Liu, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/95 631/67/1517/1709 692/699/67/1517/1709 Ablation Animals ATPases Associated with Diverse Cellular Activities - genetics ATPases Associated with Diverse Cellular Activities - metabolism Biomedical and Life Sciences Biomedicine Cell Cycle Proteins - genetics Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Chromatin Clonal deletion CRISPR DNA-Binding Proteins - metabolism Drug resistance Female Gene Expression Gene Expression Regulation, Neoplastic Gene regulation Gene Therapy Humans M gene Mice Mitosis Nocodazole Ovarian cancer Ovarian Neoplasms - pathology p53 Protein Signal Transduction Trans-Activators - genetics Tumorigenesis Xenografts
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