Tafazzin deficiency attenuates anti-cluster of differentiation 40 and interleukin-4 activation of mouse B lymphocytes

Barth syndrome (BTHS) is a rare X-linked genetic disease caused by mutations in TAFAZZIN. The tafazzin (Taz) protein is a cardiolipin remodeling enzyme required for maintaining mitochondrial function. Patients with BTHS exhibit impaired mitochondrial respiratory chain and metabolic function and are...

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Veröffentlicht in:	Cell and tissue research 2022-12, Vol.390 (3), p.429-439
Hauptverfasser:	Zegallai, Hana M., Abu-El-Rub, Ejlal, Mejia, Edgard M., Sparagna, Genevieve C., Cole, Laura K., Marshall, Aaron J., Hatch, Grant M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - deficiency Acyltransferases - genetics Animals Antigens B cells B-Lymphocytes - metabolism Barth Syndrome - genetics Barth Syndrome - metabolism Bioenergetics Biomedical and Life Sciences Biomedicine Cardiolipin Cardiolipins - metabolism CD40 antigen CD40 Antigens - metabolism CD69 antigen CD86 antigen Cell activation Cell proliferation Cytokines Diphosphatidylglycerol Disease susceptibility Electron transport Enzymes Gene expression Glycolysis Health aspects Human Genetics Humoral immunity Immunogenicity Immunoglobulin G Immunoglobulin M Immunoglobulins Interleukin 4 Interleukin-4 - pharmacology Interleukins Lymphocytes B Lymphocytes T Membrane lipids Mice Mitochondria Molecular Medicine Oxidative phosphorylation Phosphorylation Proteasome Endopeptidase Complex - metabolism Proteasomes Proteolysis Proteomics Regular Article RNA Surface markers T cells Transcription Factors - metabolism
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