ARHGAP–RhoA signaling provokes homotypic adhesion-triggered cell death of metastasized diffuse-type gastric cancer

Genetic alteration of Rho GTPase-activating proteins (ARHGAP) and GTPase RhoA is a hallmark of diffuse-type gastric cancer and elucidating its biological significance is critical to comprehensively understanding this malignancy. Here, we report that gene fusions of ARHGAP6/ARHGAP26 are frequent gene...

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Veröffentlicht in:	Oncogene 2022-10, Vol.41 (43), p.4779-4794
Hauptverfasser:	Komatsu, Masayuki, Ichikawa, Hitoshi, Chiwaki, Fumiko, Sakamoto, Hiromi, Komatsuzaki, Rie, Asaumi, Makoto, Tsunoyama, Kazuhisa, Fukagawa, Takeo, Matsushita, Hiromichi, Boku, Narikazu, Matsusaki, Keisuke, Takeshita, Fumitaka, Yoshida, Teruhiko, Sasaki, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 13/31 13/44 13/89 14/1 14/19 14/35 38/39 38/61 631/67/1504/1829 631/67/395 631/80/82/23 82/80 Actin Apoptosis Ascites Cell Biology Cell death E-cadherin Gastric cancer Genes Genomes Human Genetics Internal Medicine Malignancy Medical prognosis Medicine Medicine & Public Health Metastasis Mutation Oncology Pancreatic cancer Research centers RhoA protein Tumor cell lines Tumors
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