Secretome analysis reveals reduced expression of COL4A2 in hypoxic cancer-associated fibroblasts with a tumor-promoting function in gastric cancer

Background Cancer-associated fibroblasts (CAFs) are major components of the tumor microenvironment (TME). Hypoxic TME is known to promote tumor progression. However, how a hypoxic condition regulates CAFs remains elusive. Methods To investigate the underlying mechanism involved in the regulation of...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2023-07, Vol.149 (8), p.4477-4487
Hauptverfasser:	Park, Seo-Gyu, Ji, Mi-Jung, Ham, In-Hye, Shin, Yoon-Hee, Lee, Su-Min, Lee, Chang Hoon, Kim, Eunjung, Hur, Hoon, Park, Hyun-Mee, Kim, Jae-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Research Cell migration Fibroblasts Gastric cancer Hematology Hypoxia Hypoxia-inducible factor 1a Internal Medicine Mass spectroscopy Medicine Medicine & Public Health Oncology Secretome Trypsin Tumor microenvironment Tumors
Online-Zugang:	Volltext
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