FOXO1 is downregulated in obese mice subjected to short‐term strength training

Obesity is a worldwide health problem and is directly associated with insulin resistance and type 2 diabetes. The liver is an important organ for the control of healthy glycemic levels, since insulin resistance in this organ reduces phosphorylation of forkhead box protein 1 (FOXO1) protein, leading...

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Veröffentlicht in:	Journal of cellular physiology 2022-11, Vol.237 (11), p.4262-4274
Hauptverfasser:	Pereira, Rodrigo M., da Cruz Rodrigues, Kellen C., Sant'Ana, Marcella R., da Rocha, Alisson L., Morelli, Ana P., Veras, Allice S. C., Gaspar, Rodrigo S., da Costa Fernandes, Célio J., Teixeira, Giovana R., Simabuco, Fernando M., da Silva, Adelino S. R., Cintra, Dennys E., Ropelle, Eduardo R., Pauli, José R., de Moura, Leandro P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue AKT protein Animal models Animals Bioinformatics diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism Forkhead protein FOXO1 protein Gluconeogenesis Glucose Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Glycogens Humans Hyperglycemia Insulin Insulin - metabolism Insulin resistance Insulin Resistance - genetics insulin sensitivity Kinases Liver Liver - metabolism Mice Mice, Inbred C57BL Mice, Obese Obesity Obesity - genetics Obesity - metabolism Phosphoenolpyruvate Carboxykinase (ATP) - metabolism Phosphorylation Physical training Proteins Pyruvic acid Resistance Training short‐term strength training Sports training Strength training
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